{"id":"https://openalex.org/W2084237293","doi":"https://doi.org/10.1016/0003-9861(86)90025-1","title":"Human factor XIa cleaves fibrinogen: Effects on structure and function","display_name":"Human factor XIa cleaves fibrinogen: Effects on structure and function","publication_year":1986,"publication_date":"1986-09-01","ids":{"openalex":"https://openalex.org/W2084237293","doi":"https://doi.org/10.1016/0003-9861(86)90025-1","mag":"2084237293","pmid":"https://pubmed.ncbi.nlm.nih.gov/2944482"},"language":"en","primary_location":{"id":"doi:10.1016/0003-9861(86)90025-1","doi":"https://doi.org/10.1016/0003-9861(86)90025-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-9861(86)90025-1","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109438465","display_name":"Cheryl F. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl F. Scott","raw_affiliation_strings":["Thrombosis Research Center and Hematology/Oncology Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center and Hematology/Oncology Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056185809","display_name":"Richard L. Mentzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard L. Mentzer","raw_affiliation_strings":["Thrombosis Research Center and Hematology/Oncology Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center and Hematology/Oncology Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109032262","display_name":"Andrei Z. Budzynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrei Z. Budzynski","raw_affiliation_strings":["Thrombosis Research Center and Hematology/Oncology Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center and Hematology/Oncology Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["Thrombosis Research Center and Hematology/Oncology Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center and Hematology/Oncology Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5104652394"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":0.576,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71161865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"249","issue":"2","first_page":"480","last_page":"488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-xia","display_name":"factor XIa","score":0.996999979019165},{"id":"https://openalex.org/keywords/fibrinogen-cleavage","display_name":"fibrinogen cleavage","score":0.9269999861717224},{"id":"https://openalex.org/keywords/fibrinogenolysis","display_name":"fibrinogenolysis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/fibrin-polymerization","display_name":"fibrin polymerization","score":0.7540000081062317},{"id":"https://openalex.org/keywords/fibrin-clot-formation","display_name":"fibrin clot formation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.5609999895095825},{"id":"https://openalex.org/keywords/plasmin","display_name":"plasmin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fibrinogen-aalpha-chain","display_name":"fibrinogen alpha chain","score":0.6830000281333923},{"id":"https://openalex.org/keywords/fibrinogen-gamma-chain","display_name":"fibrinogen gamma chain","score":0.9710000157356262},{"id":"https://openalex.org/keywords/factor-xi","display_name":"factor XI","score":0.625},{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.7940000295639038},{"id":"https://openalex.org/keywords/factor-ix-activation","display_name":"factor IX activation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/surface-activation","display_name":"surface activation","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.8482272624969482},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.8009569644927979},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.7623913884162903},{"id":"https://openalex.org/C2778775115","wikidata":"https://www.wikidata.org/wiki/Q245759","display_name":"Zymogen","level":3,"score":0.7325473427772522},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.7143329381942749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6779983043670654},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5401396751403809},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5087123513221741},{"id":"https://openalex.org/C2777444498","wikidata":"https://www.wikidata.org/wiki/Q423701","display_name":"Factor X","level":4,"score":0.4479154050350189},{"id":"https://openalex.org/C2779672106","wikidata":"https://www.wikidata.org/wiki/Q423712","display_name":"Factor XIII","level":3,"score":0.41829797625541687},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.4124612808227539},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.23971018195152283},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21956390142440796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1998695731163025},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.12266916036605835},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11608549952507019},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.10133087635040283}],"mesh":[{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005172","descriptor_name":"Factor XI","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013918","descriptor_name":"Thrombin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015945","descriptor_name":"Factor XIa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0003-9861(86)90025-1","doi":"https://doi.org/10.1016/0003-9861(86)90025-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-9861(86)90025-1","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:2944482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2944482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G173662705","display_name":null,"funder_award_id":"HL 14217","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1839165806","display_name":null,"funder_award_id":"HL 24365","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W90853429","https://openalex.org/W1500508767","https://openalex.org/W1541525472","https://openalex.org/W1577778242","https://openalex.org/W1588491159","https://openalex.org/W1590895486","https://openalex.org/W1964281316","https://openalex.org/W1964757326","https://openalex.org/W1975474821","https://openalex.org/W1996826759","https://openalex.org/W2023615408","https://openalex.org/W2037081745","https://openalex.org/W2040337859","https://openalex.org/W2042683625","https://openalex.org/W2045845326","https://openalex.org/W2064755136","https://openalex.org/W2077237408","https://openalex.org/W2078128292","https://openalex.org/W2083596829","https://openalex.org/W2109939055","https://openalex.org/W2119460480","https://openalex.org/W2210097750","https://openalex.org/W2395892833","https://openalex.org/W2407142497","https://openalex.org/W2419140294"],"related_works":["https://openalex.org/W1590895486","https://openalex.org/W2001888395","https://openalex.org/W2007707310","https://openalex.org/W1504351773","https://openalex.org/W2560382377","https://openalex.org/W2115151630","https://openalex.org/W1844074625","https://openalex.org/W2550940171","https://openalex.org/W1973642951","https://openalex.org/W7095927506"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
