{"id":"https://openalex.org/W2084147261","doi":"https://doi.org/10.3824/stembook.1.29.1","title":"Modeling germ cell differentiation","display_name":"Modeling germ cell differentiation","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2084147261","doi":"https://doi.org/10.3824/stembook.1.29.1","mag":"2084147261"},"language":"en","primary_location":{"id":"doi:10.3824/stembook.1.29.1","doi":"https://doi.org/10.3824/stembook.1.29.1","is_oa":true,"landing_page_url":"https://doi.org/10.3824/stembook.1.29.1","pdf_url":"https://www.stembook.org/sites/default/files/pubnode/2b4690614403528fbe04c0f7b4df2cd6f5ab0267/Modeling_germ_cell_differentiation/Modeling_germ_cell_differentiation.pdf","source":{"id":"https://openalex.org/S4210169425","display_name":"StemBook","issn_l":"1940-3429","issn":["1940-3429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"StemBook","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.stembook.org/sites/default/files/pubnode/2b4690614403528fbe04c0f7b4df2cd6f5ab0267/Modeling_germ_cell_differentiation/Modeling_germ_cell_differentiation.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072347898","display_name":"Niels Geijsen","orcid":"https://orcid.org/0000-0003-3592-4353","observed_orcids":["https://orcid.org/0000-0003-3592-4353"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Niels Geijsen","raw_affiliation_strings":["Harvard Stem Cell Institute ,","Harvard Stem Cell Institute, Massachusetts General Hospital, Center for Regenerative Medicine, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Stem Cell Institute ,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Massachusetts General Hospital, Center for Regenerative Medicine, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210157861"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072347898"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210157861"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14026498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/germ-cell-differentiation","display_name":"germ cell differentiation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/germplasm","display_name":"germplasm","score":0.8420000076293945},{"id":"https://openalex.org/keywords/germline-stem-cells","display_name":"germline stem cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/germ-cell-specification","display_name":"germ cell specification","score":0.9319999814033508},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8119999766349792},{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9589999914169312},{"id":"https://openalex.org/keywords/egg-polarity","display_name":"egg polarity","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.7589343190193176},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4597170352935791},{"id":"https://openalex.org/C2780258238","wikidata":"https://www.wikidata.org/wiki/Q2520842","display_name":"Germ","level":2,"score":0.4113519489765167},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3785043954849243},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3718607723712921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36771517992019653},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12491416931152344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3824/stembook.1.29.1","doi":"https://doi.org/10.3824/stembook.1.29.1","is_oa":true,"landing_page_url":"https://doi.org/10.3824/stembook.1.29.1","pdf_url":"https://www.stembook.org/sites/default/files/pubnode/2b4690614403528fbe04c0f7b4df2cd6f5ab0267/Modeling_germ_cell_differentiation/Modeling_germ_cell_differentiation.pdf","source":{"id":"https://openalex.org/S4210169425","display_name":"StemBook","issn_l":"1940-3429","issn":["1940-3429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"StemBook","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.634.7345","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.634.7345","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.stembook.org/sites/default/files/pubnode/2b4690614403528fbe04c0f7b4df2cd6f5ab0267/Modeling_germ_cell_differentiation/Modeling_germ_cell_differentiation.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3824/stembook.1.29.1","doi":"https://doi.org/10.3824/stembook.1.29.1","is_oa":true,"landing_page_url":"https://doi.org/10.3824/stembook.1.29.1","pdf_url":"https://www.stembook.org/sites/default/files/pubnode/2b4690614403528fbe04c0f7b4df2cd6f5ab0267/Modeling_germ_cell_differentiation/Modeling_germ_cell_differentiation.pdf","source":{"id":"https://openalex.org/S4210169425","display_name":"StemBook","issn_l":"1940-3429","issn":["1940-3429"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"StemBook","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2084147261.pdf","grobid_xml":"https://content.openalex.org/works/W2084147261.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W146585592","https://openalex.org/W1559389849","https://openalex.org/W1569812862","https://openalex.org/W1948275303","https://openalex.org/W1965719589","https://openalex.org/W1977135603","https://openalex.org/W1979431956","https://openalex.org/W1979861092","https://openalex.org/W1992924696","https://openalex.org/W1996430474","https://openalex.org/W2007003847","https://openalex.org/W2016241188","https://openalex.org/W2021761983","https://openalex.org/W2027267818","https://openalex.org/W2028067787","https://openalex.org/W2031798764","https://openalex.org/W2036654302","https://openalex.org/W2038443908","https://openalex.org/W2038752568","https://openalex.org/W2041288808","https://openalex.org/W2042480114","https://openalex.org/W2047040065","https://openalex.org/W2049197049","https://openalex.org/W2064361935","https://openalex.org/W2078142069","https://openalex.org/W2078337444","https://openalex.org/W2089897307","https://openalex.org/W2090510808","https://openalex.org/W2115183068","https://openalex.org/W2143023822","https://openalex.org/W2152363904","https://openalex.org/W2162504561","https://openalex.org/W2168684990","https://openalex.org/W2414777929","https://openalex.org/W2595773300","https://openalex.org/W6734512569"],"related_works":["https://openalex.org/W4390049601","https://openalex.org/W2024918567","https://openalex.org/W2786536430","https://openalex.org/W2808618190","https://openalex.org/W2138292740","https://openalex.org/W1559894171","https://openalex.org/W2309303203","https://openalex.org/W1595011252","https://openalex.org/W2011085458","https://openalex.org/W2563157636"],"abstract_inverted_index":{"Endowed":[0],"with":[1],"the":[2,6,10,29,48,66,73,77,93,100,107,126,135,143,147,157,161,171,193],"task":[3],"of":[4,32,68,76,115,129,146,163,178],"transmitting":[5],"genetic":[7],"information":[8],"to":[9,35,72,105,186],"next":[11],"generation,":[12],"germ":[13,33,52,61,101,116,121,164,179,189],"cells":[14,19,34,97,122,165],"are":[15,103,123],"without":[16],"doubt":[17],"critical":[18],"for":[20],"any":[21],"species":[22,36],"that":[23,98,120,141],"multiplies":[24],"through":[25,65,166],"sexual":[26],"reproduction.":[27],"Recognizing":[28],"vital":[30],"importance":[31],"survival,":[37],"in":[38,181],"many":[39],"lower":[40,182],"organisms":[41,183],"including":[42],"Drosophila":[43],"Melanogaster,":[44],"Xenopus":[45],"Laevis":[46],"and":[47,81,85,89,138],"Zebrafish":[49],"(Danio":[50],"Rerio)":[51],"cell":[53,62,117,190],"formation":[54],"is":[55,184],"rigidly":[56],"programmed.":[57],"In":[58,149],"these":[59],"species,":[60,151],"specification":[63,118,137,162],"occurs":[64,199],"localization":[67],"so-called":[69],"\u201cgerm":[70],"plasm\u201d":[71],"posterior":[74],"pole":[75],"unfertilized":[78],"egg":[79],"(Baughman":[80],"Geijsen,":[82],";":[83,87],"Jin":[84],"Xie,":[86],"Strome":[88],"Lehmann,":[90],"2007).":[91],"Following":[92],"first":[94],"cleavage":[95],"divisions,":[96],"receive":[99],"plasm":[102,180],"destined":[104],"become":[106],"germline":[108,172],"stem":[109],"cells.":[110],"Such":[111],"a":[112,188],"pre-determination":[113],"model":[114],"assures":[119],"set-aside":[124],"during":[125],"earliest":[127],"steps":[128],"embryonic":[130],"development,":[131],"protecting":[132],"them":[133],"from":[134],"lineage":[136],"differentiation":[139],"events":[140],"craft":[142],"body":[144],"plan":[145],"embryo.":[148],"egg-laying":[150],"which":[152,197],"have":[153],"limited":[154],"control":[155],"over":[156],"embryo's":[158],"extra-embryonic":[159],"milieu,":[160],"pre-localized":[167],"germ-plasm":[168],"may":[169],"protect":[170],"against":[173],"environmental":[174],"influences.":[175],"The":[176],"inheritance":[177],"sufficient":[185],"install":[187],"identity,":[191],"but":[192],"specific":[194],"mechanisms":[195],"by":[196],"this":[198],"remain":[200],"unknown.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}