{"id":"https://openalex.org/W2084097944","doi":"https://doi.org/10.1002/eji.1830251235","title":"Definition of sites on HLA\u2010DR1 involved in the T cell response to staphylococcal enterotoxins E and C2","display_name":"Definition of sites on HLA\u2010DR1 involved in the T cell response to staphylococcal enterotoxins E and C2","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2084097944","doi":"https://doi.org/10.1002/eji.1830251235","mag":"2084097944","pmid":"https://pubmed.ncbi.nlm.nih.gov/8566035"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830251235","doi":"https://doi.org/10.1002/eji.1830251235","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830251235","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109924694","display_name":"Roseanna E. G. Hargreaves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roseanna E. G. Hargreaves","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, GB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, GB","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053634789","display_name":"Rossalyn D. Brehm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rossalyn D. Brehm","raw_affiliation_strings":["CAMR, Porton Down, Salisbury, Wiltshire, GB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAMR, Porton Down, Salisbury, Wiltshire, GB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110143440","display_name":"Howard S. Tranter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard Tranter","raw_affiliation_strings":["CAMR, Porton Down, Salisbury, Wiltshire, GB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAMR, Porton Down, Salisbury, Wiltshire, GB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001285503","display_name":"Anthony \u039d. Warrens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony N. Warrens","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, GB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, GB","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101470033","display_name":"Giovanna Lombardi","orcid":"https://orcid.org/0000-0003-4496-3215","observed_orcids":["https://orcid.org/0000-0003-4496-3215"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giovanna Lombardi","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, GB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, GB","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108242111","display_name":"Robert Ian Lechler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Robert I. Lechler","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, GB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, GB","institution_ids":["https://openalex.org/I2801748203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108242111"],"corresponding_institution_ids":["https://openalex.org/I2801748203"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.6236,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.61017535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"25","issue":"12","first_page":"3437","last_page":"3444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.12049999833106995,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-dr1","display_name":"HLA-DR1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/staphylococcal-enterotoxin-e","display_name":"staphylococcal enterotoxin E","score":0.9670000076293945},{"id":"https://openalex.org/keywords/staphylococcal-enterotoxin-c2","display_name":"staphylococcal enterotoxin C2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/superantigens","display_name":"superantigens","score":0.9810000061988831},{"id":"https://openalex.org/keywords/exon-shuffling","display_name":"exon shuffling","score":0.6949999928474426},{"id":"https://openalex.org/keywords/alpha-1-domain","display_name":"alpha 1 domain","score":0.8510000109672546},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6862531900405884},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5846554040908813},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.5735759735107422},{"id":"https://openalex.org/C152204938","wikidata":"https://www.wikidata.org/wiki/Q4735158","display_name":"Alpha chain","level":3,"score":0.5424244403839111},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5347368717193604},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.5048792958259583},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5044459104537964},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4947940707206726},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4674350321292877},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.4473343789577484},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.43970999121665955},{"id":"https://openalex.org/C36333154","wikidata":"https://www.wikidata.org/wiki/Q772950","display_name":"Superantigen","level":4,"score":0.41044723987579346},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2599327564239502},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.24352332949638367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24272990226745605},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2220810353755951},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20487064123153687},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15934473276138306},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015798","descriptor_name":"HLA-DR1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015798","descriptor_name":"HLA-DR1 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015798","descriptor_name":"HLA-DR1 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018089","descriptor_name":"Superantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830251235","doi":"https://doi.org/10.1002/eji.1830251235","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830251235","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:8566035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8566035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1483035379","https://openalex.org/W1522184639","https://openalex.org/W1529780506","https://openalex.org/W1562079541","https://openalex.org/W1577432969","https://openalex.org/W1618752241","https://openalex.org/W1933303272","https://openalex.org/W1968886938","https://openalex.org/W1982917969","https://openalex.org/W1986958051","https://openalex.org/W2000862651","https://openalex.org/W2000980350","https://openalex.org/W2003650622","https://openalex.org/W2004828548","https://openalex.org/W2007721484","https://openalex.org/W2013542144","https://openalex.org/W2023308742","https://openalex.org/W2034181842","https://openalex.org/W2036052491","https://openalex.org/W2039925582","https://openalex.org/W2041820353","https://openalex.org/W2049478058","https://openalex.org/W2062114604","https://openalex.org/W2073078847","https://openalex.org/W2076295240","https://openalex.org/W2081841441","https://openalex.org/W2086417745","https://openalex.org/W2088073112","https://openalex.org/W2099908018","https://openalex.org/W2106481565","https://openalex.org/W2121203525","https://openalex.org/W2129840067","https://openalex.org/W2156987473","https://openalex.org/W2159262098"],"related_works":["https://openalex.org/W1999959706","https://openalex.org/W2121203525","https://openalex.org/W1933303272","https://openalex.org/W2099908018","https://openalex.org/W2076295240","https://openalex.org/W2034181842","https://openalex.org/W2071602820","https://openalex.org/W1527542111","https://openalex.org/W2159328613","https://openalex.org/W1928615349"],"abstract_inverted_index":{"We":[0],"have":[1,266],"exploited":[2],"the":[3,25,36,57,77,81,93,115,118,125,137,146,155,182,213,226,231,239,244,271,277,294,298,313],"relative":[4],"inefficiency":[5],"of":[6,24,80,105,128,132,200,212,228,288,297,315],"interaction":[7],"between":[8,110],"staphylococcal":[9],"enterotoxins,":[10],"SEE":[11,55,156],"or":[12,179],"SEC2,":[13,198],"and":[14,67,89,112,205,218,236,276,280],"H-2Ek":[15],"compared":[16],"to":[17,20,40,53,56,69,248],"HLA-DR1":[18],"molecules":[19,50],"deduce":[21],"which":[22,262],"regions":[23],"major":[26],"histocompatibility":[27],"complex":[28],"(MHC)":[29],"class":[30,48,82,299],"II":[31,49,83,300],"molecule":[32,84],"are":[33],"involved":[34],"in":[35,124,130,181,195,238,261,312],"T":[37,58,73,86,188,245,316],"cell":[38,59,65,87,189,246,317],"response":[39,157,247],"these":[41,252,263],"superantigens.":[42],"Transfectants":[43],"expressing":[44,202],"hybrid":[45],"DR/H-2E":[46],"MHC":[47],"were":[51,101],"used":[52],"present":[54],"receptor":[60],"V":[61],"beta":[62,94,126,206,219,272],"8.1-expressing":[63],"Jurkat":[64],"line,":[66],"SEC2":[68],"human":[70],"peripheral":[71],"blood":[72],"cells.":[74],"For":[75,197],"SEE,":[76],"critical":[78],"region":[79],"for":[85,90,136],"reactivity":[88,190],"binding":[91,268,291],"was":[92,134,143],"1":[95,185,220,241,273,279],"domain":[96,186,242,274],"alpha-helix.":[97],"The":[98],"functional":[99,139],"data":[100,253],"corroborated":[102],"by":[103,145,258,286],"measurements":[104],"direct":[106],"binding.":[107,196],"Sequence":[108],"comparison":[109],"DR":[111,183,305],"H-2E":[113,223],"raised":[114],"possibility":[116],"that":[117,148,163,210],"glutamic":[119,165],"acid":[120,166,173],"at":[121,151,167,175,233],"position":[122,177],"84":[123],"chain":[127,207],"H-2Ek,":[129],"place":[131],"glycine":[133],"responsible":[135],"observed":[138],"effects.":[140],"This":[141],"suggestion":[142],"supported":[144,154],"finding":[147],"DQw2":[149],"(glutamine":[150],"84)":[152],"transfectants":[153,201],"much":[158],"more":[159],"efficiently":[160],"than":[161],"DQw6":[162],"has":[164],"this":[168],"position.":[169],"In":[170],"addition,":[171],"amino":[172],"substitutions":[174,232],"either":[176],"36":[178,235],"39":[180,237],"alpha":[184,204,214,216,240,278,281],"abolished":[187,243],"without":[191],"any":[192],"obvious":[193],"alteration":[194],"use":[199],"exon-shuffled":[203],"genes":[208],"showed":[209],"replacement":[211],"1,":[215],"2":[217,282],"domains":[221,283],"with":[222],"sequence":[224],"inhibited":[225],"presentation":[227],"SEC2.":[229,249],"Similarly,":[230],"positions":[234],"Taken":[250],"together,":[251],"may":[254,309],"be":[255,310],"best":[256],"explained":[257],"a":[259,289],"model":[260],"two":[264,303],"toxins":[265],"primary":[267],"sites":[269],"on":[270,293],"(SEE)":[275],"(SEC2),":[284],"but":[285],"virtue":[287],"secondary":[290],"site":[292],"opposite":[295],"surface":[296],"molecule,":[301],"cross-link":[302],"adjacent":[304],"molecules.":[306],"Such":[307],"cross-linking":[308],"important":[311],"induction":[314],"reactivity.":[318]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}