{"id":"https://openalex.org/W2084041908","doi":"https://doi.org/10.1371/journal.pone.0070123","title":"MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex","display_name":"MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex","publication_year":2013,"publication_date":"2013-07-19","ids":{"openalex":"https://openalex.org/W2084041908","doi":"https://doi.org/10.1371/journal.pone.0070123","mag":"2084041908","pmid":"https://pubmed.ncbi.nlm.nih.gov/23894602","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3716611"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0070123","doi":"https://doi.org/10.1371/journal.pone.0070123","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0070123","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070123&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070123&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069247351","display_name":"Thomas Lettner","orcid":"https://orcid.org/0000-0002-8130-8394","observed_orcids":["https://orcid.org/0000-0002-8130-8394"]},"institutions":[{"id":"https://openalex.org/I4210148886","display_name":"EB House Austria","ror":"https://ror.org/059q6am89","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210148886"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Thomas Lettner","raw_affiliation_strings":["Division of Experimental Dermatology and EB House Austria, Salzburg, Austria. thomas.lettner@gmail.com","Division of Experimental Dermatology and EB House Austria, Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Dermatology and EB House Austria, Salzburg, Austria. thomas.lettner@gmail.com","institution_ids":["https://openalex.org/I4210148886"]},{"raw_affiliation_string":"Division of Experimental Dermatology and EB House Austria, Salzburg, Austria","institution_ids":["https://openalex.org/I4210148886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078488796","display_name":"Roland Lang","orcid":"https://orcid.org/0000-0002-9750-0188","observed_orcids":["https://orcid.org/0000-0002-9750-0188"]},"institutions":[{"id":"https://openalex.org/I27945538","display_name":"Paracelsus Medical University","ror":"https://ror.org/03z3mg085","country_code":"AT","type":"education","lineage":["https://openalex.org/I27945538"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Roland Lang","raw_affiliation_strings":["Department of Dermatology, Paracelsus Medical University, Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Paracelsus Medical University, Salzburg, Austria","institution_ids":["https://openalex.org/I27945538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038342878","display_name":"Alfred Klausegger","orcid":"https://orcid.org/0000-0001-6160-9934","observed_orcids":["https://orcid.org/0000-0001-6160-9934"]},"institutions":[{"id":"https://openalex.org/I4210148886","display_name":"EB House Austria","ror":"https://ror.org/059q6am89","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210148886"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Alfred Klausegger","raw_affiliation_strings":["Division of Experimental Dermatology and EB House Austria, Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Dermatology and EB House Austria, Salzburg, Austria","institution_ids":["https://openalex.org/I4210148886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019955434","display_name":"Stefan Hainzl","orcid":"https://orcid.org/0000-0001-6542-0039","observed_orcids":["https://orcid.org/0000-0001-6542-0039"]},"institutions":[{"id":"https://openalex.org/I4210148886","display_name":"EB House Austria","ror":"https://ror.org/059q6am89","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210148886"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Stefan Hainzl","raw_affiliation_strings":["Division of Experimental Dermatology and EB House Austria, Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Dermatology and EB House Austria, Salzburg, Austria","institution_ids":["https://openalex.org/I4210148886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010781386","display_name":"Johann Wolfgang Bauer","orcid":"https://orcid.org/0000-0002-6085-9170","observed_orcids":["https://orcid.org/0000-0002-6085-9170"]},"institutions":[{"id":"https://openalex.org/I4210148886","display_name":"EB House Austria","ror":"https://ror.org/059q6am89","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210148886"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Johann W. Bauer","raw_affiliation_strings":["Division of Experimental Dermatology and EB House Austria, Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Dermatology and EB House Austria, Salzburg, Austria","institution_ids":["https://openalex.org/I4210148886"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001546897","display_name":"Verena Wally","orcid":"https://orcid.org/0000-0001-8705-3890","observed_orcids":["https://orcid.org/0000-0001-8705-3890"]},"institutions":[{"id":"https://openalex.org/I4210148886","display_name":"EB House Austria","ror":"https://ror.org/059q6am89","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210148886"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Verena Wally","raw_affiliation_strings":["Division of Experimental Dermatology and EB House Austria, Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Dermatology and EB House Austria, Salzburg, Austria","institution_ids":["https://openalex.org/I4210148886"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069247351"],"corresponding_institution_ids":["https://openalex.org/I4210148886"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.4378,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.56344111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"7","first_page":"e70123","last_page":"e70123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermolysis-bullosa-simplex","display_name":"epidermolysis bullosa simplex","score":0.996999979019165},{"id":"https://openalex.org/keywords/keratin-5","display_name":"keratin 5","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9660000205039978},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9629999995231628},{"id":"https://openalex.org/keywords/kallikrein-related-peptidases","display_name":"kallikrein-related peptidases","score":0.8980000019073486},{"id":"https://openalex.org/keywords/blister-fluid","display_name":"blister fluid","score":0.7120000123977661},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2778405274","wikidata":"https://www.wikidata.org/wiki/Q3124960","display_name":"Epidermolysis bullosa simplex","level":3,"score":0.9101548194885254},{"id":"https://openalex.org/C2778266373","wikidata":"https://www.wikidata.org/wiki/Q14864175","display_name":"Keratin 14","level":5,"score":0.851218044757843},{"id":"https://openalex.org/C170178370","wikidata":"https://www.wikidata.org/wiki/Q14907905","display_name":"Keratin 5","level":3,"score":0.7166857123374939},{"id":"https://openalex.org/C2781207856","wikidata":"https://www.wikidata.org/wiki/Q923020","display_name":"Epidermolysis bullosa","level":2,"score":0.6449676752090454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4722553789615631},{"id":"https://openalex.org/C68324877","wikidata":"https://www.wikidata.org/wiki/Q421859","display_name":"Interleukin 8","level":3,"score":0.42318958044052124},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.4152156114578247},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3802070915699005},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3772144317626953},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3474850058555603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3032117187976837},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15084326267242432},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1432735025882721},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.0},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000099149","descriptor_name":"Ezrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016110","descriptor_name":"Epidermolysis Bullosa Simplex","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016110","descriptor_name":"Epidermolysis Bullosa Simplex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016110","descriptor_name":"Epidermolysis Bullosa Simplex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064067","descriptor_name":"Rho Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064067","descriptor_name":"Rho Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0070123","doi":"https://doi.org/10.1371/journal.pone.0070123","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0070123","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070123&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2715390","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3716611","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3716611","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3716611","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23894602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23894602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ec5c7f4f4903442089541dbfc16b36d1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ec5c7f4f4903442089541dbfc16b36d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 7, p e70123 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0070123","doi":"https://doi.org/10.1371/journal.pone.0070123","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0070123","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070123&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327318","display_name":"Paracelsus Medizinische Privatuniversit\u00e4t","ror":"https://ror.org/03z3mg085"},{"id":"https://openalex.org/F4320330196","display_name":"DEBRA Austria","ror":"https://ror.org/056b2ve81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2084041908.pdf","grobid_xml":"https://content.openalex.org/works/W2084041908.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1525734429","https://openalex.org/W1544923801","https://openalex.org/W1555692789","https://openalex.org/W1559593594","https://openalex.org/W1578854396","https://openalex.org/W1932179104","https://openalex.org/W1965292419","https://openalex.org/W1966178848","https://openalex.org/W1968261842","https://openalex.org/W1975817555","https://openalex.org/W1977781495","https://openalex.org/W1988498281","https://openalex.org/W1992917842","https://openalex.org/W1993860255","https://openalex.org/W2000337723","https://openalex.org/W2002827724","https://openalex.org/W2003386949","https://openalex.org/W2003656051","https://openalex.org/W2019004412","https://openalex.org/W2039970883","https://openalex.org/W2049811270","https://openalex.org/W2059032249","https://openalex.org/W2060406593","https://openalex.org/W2061488186","https://openalex.org/W2077030142","https://openalex.org/W2104673447","https://openalex.org/W2107266832","https://openalex.org/W2107277218","https://openalex.org/W2111778006","https://openalex.org/W2114360920","https://openalex.org/W2122190480","https://openalex.org/W2134957357","https://openalex.org/W2137395561","https://openalex.org/W2139630595","https://openalex.org/W2139879939","https://openalex.org/W2141021726","https://openalex.org/W2154401382","https://openalex.org/W2155496792","https://openalex.org/W2155795208","https://openalex.org/W2158217645","https://openalex.org/W2159638184","https://openalex.org/W2166673123","https://openalex.org/W2270306283","https://openalex.org/W2490386721"],"related_works":["https://openalex.org/W7096846070","https://openalex.org/W7095941751","https://openalex.org/W7203895086","https://openalex.org/W2214582647","https://openalex.org/W1988498281","https://openalex.org/W4402169346","https://openalex.org/W2913159145","https://openalex.org/W6959029993","https://openalex.org/W2075283420","https://openalex.org/W6940065437"],"abstract_inverted_index":{"Epidermolysis":[0],"bullosa":[1,27,164],"refers":[2],"to":[3,66,82,109],"a":[4],"group":[5],"of":[6,12,25,62,117,123,132,142,162],"genodermatoses":[7],"that":[8,140],"affects":[9],"the":[10,22,44,48,59,94,124,159,175],"integrity":[11],"epithelial":[13],"layers,":[14],"phenotypically":[15],"resulting":[16],"in":[17,31,42,87,155],"severe":[18],"skin":[19],"blistering.":[20],"Dowling-Meara,":[21],"major":[23],"subtype":[24],"epidermolysis":[26,163],"simplex,":[28],"is":[29,56,145],"inherited":[30],"an":[32],"autosomal":[33],"dominant":[34],"manner":[35],"and":[36,58,80,98,106,119,134,170,174],"can":[37],"be":[38,110],"caused":[39],"by":[40],"mutations":[41,95],"either":[43],"keratin-5":[45],"(K5)":[46],"or":[47],"keratin-14":[49],"(K14)":[50],"gene.":[51],"Currently,":[52],"no":[53],"therapeutic":[54,69,180],"approach":[55],"known,":[57],"main":[60],"objective":[61],"this":[63],"study":[64],"was":[65],"identify":[67,83],"novel":[68],"targets.":[70,181],"We":[71,102,112,137],"used":[72],"microarray":[73],"analysis,":[74],"semi-quantitative":[75],"real-time":[76],"PCR,":[77],"western":[78],"blot":[79],"ELISA":[81],"differentially":[84],"regulated":[85],"genes":[86,144],"two":[88],"K14":[89,96,99],"mutant":[90],"cell":[91],"lines":[92],"carrying":[93],"R125P":[97],"R125H,":[100],"respectively.":[101],"found":[103,114],"kallikrein-related":[104],"peptidases":[105],"matrix":[107,172],"metalloproteinases":[108],"upregulated.":[111],"also":[113],"elevated":[115],"expression":[116,131,141],"chemokines,":[118],"we":[120,157],"observed":[121],"deregulation":[122],"Cdc42":[125],"pathway":[126],"as":[127,129,178],"well":[128],"aberrant":[130],"cytokeratins":[133],"junction":[135],"proteins.":[136],"further":[138],"demonstrated,":[139],"these":[143,153],"dependent":[146],"on":[147],"interleukin-1":[148],"\u03b2":[149],"signaling.":[150],"To":[151],"evaluate":[152],"data":[154],"vivo":[156],"analysed":[158],"blister":[160],"fluids":[161],"simplex":[165],"patients":[166],"vs.":[167],"healthy":[168],"controls":[169],"identified":[171],"metalloproteinase-9":[173],"chemokine":[176],"CXCL8/IL-8":[177],"potential":[179]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}