{"id":"https://openalex.org/W2083993202","doi":"https://doi.org/10.1001/jama.280.10.887","title":"Oral Famciclovir for the Suppression of Recurrent Genital Herpes A Randomized Controlled Trial","display_name":"Oral Famciclovir for the Suppression of Recurrent Genital Herpes A Randomized Controlled Trial","publication_year":1998,"publication_date":"1998-09-09","ids":{"openalex":"https://openalex.org/W2083993202","doi":"https://doi.org/10.1001/jama.280.10.887","mag":"2083993202","pmid":"https://pubmed.ncbi.nlm.nih.gov/9739972"},"language":"en","primary_location":{"id":"doi:10.1001/jama.280.10.887","doi":"https://doi.org/10.1001/jama.280.10.887","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.280.10.887","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017186738","display_name":"Francisco D\u00edaz\u2010Mitoma","orcid":"https://orcid.org/0000-0003-0292-4859","observed_orcids":["https://orcid.org/0000-0003-0292-4859"]},"institutions":[{"id":"https://openalex.org/I2799330578","display_name":"Children's Hospital of Eastern Ontario","ror":"https://ror.org/05nsbhw27","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799330578"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Francisco Diaz-Mitoma","raw_affiliation_strings":["Children's Hospital of Eastern Ontario, Ottawa, Canada. diaz@cheo.on.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Eastern Ontario, Ottawa, Canada. diaz@cheo.on.ca","institution_ids":["https://openalex.org/I2799330578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017186738"],"corresponding_institution_ids":["https://openalex.org/I2799330578"],"apc_list":null,"apc_paid":null,"fwci":7.8478,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.97926601,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"280","issue":"10","first_page":"887","last_page":"887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/famciclovir","display_name":"famciclovir","score":0.9950000047683716},{"id":"https://openalex.org/keywords/recurrent-genital-herpes","display_name":"recurrent genital herpes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.9419999718666077},{"id":"https://openalex.org/keywords/suppressive-therapy","display_name":"suppressive therapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6389999985694885},{"id":"https://openalex.org/keywords/time-to-recurrence","display_name":"time to recurrence","score":0.6140000224113464},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6919999718666077},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2776723293","wikidata":"https://www.wikidata.org/wiki/Q420186","display_name":"Famciclovir","level":3,"score":0.9591753482818604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9499561786651611},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6975750923156738},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5785279273986816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5388557314872742},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41164153814315796},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37142449617385864},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36794912815093994},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17378389835357666},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1306755542755127},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.060751527547836304},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077595","descriptor_name":"Famciclovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006558","descriptor_name":"Herpes Genitalis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015075","descriptor_name":"2-Aminopurine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015075","descriptor_name":"2-Aminopurine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015075","descriptor_name":"2-Aminopurine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015075","descriptor_name":"2-Aminopurine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/jama.280.10.887","doi":"https://doi.org/10.1001/jama.280.10.887","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.280.10.887","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:9739972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9739972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323298","display_name":"H\u00e1sk\u00f3li \u00cdslands","ror":"https://ror.org/01db6h964"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W5425512","https://openalex.org/W215165530","https://openalex.org/W1273397165","https://openalex.org/W1964522214","https://openalex.org/W1970118148","https://openalex.org/W1973082666","https://openalex.org/W1981081771","https://openalex.org/W1983098285","https://openalex.org/W2047342003","https://openalex.org/W2049734705","https://openalex.org/W2050016222","https://openalex.org/W2058792253","https://openalex.org/W2071573810","https://openalex.org/W2085796790","https://openalex.org/W2115012618","https://openalex.org/W2139922956","https://openalex.org/W2159821675","https://openalex.org/W2334917064","https://openalex.org/W2419099238","https://openalex.org/W2729399724","https://openalex.org/W4235830486","https://openalex.org/W4300175960"],"related_works":["https://openalex.org/W2091590689","https://openalex.org/W1970118148","https://openalex.org/W2059870306","https://openalex.org/W2058343426","https://openalex.org/W1995426755","https://openalex.org/W1973082666","https://openalex.org/W2129184374","https://openalex.org/W2273101334","https://openalex.org/W3025943257","https://openalex.org/W4301962591"],"abstract_inverted_index":{"CONTEXT:":[0],"Recurrent":[1],"genital":[2,36,83,132,166,268],"herpes":[3,84,167],"simplex":[4],"virus":[5],"(HSV)":[6],"may":[7,13],"be":[8,15],"treated":[9],"episodically,":[10],"but":[11],"this":[12],"not":[14],"sufficient":[16],"for":[17,120,180,192,264],"patients":[18,64,138,198,272],"with":[19,74,189,235,273],"frequent":[20,274],"recurrences.":[21,275],"OBJECTIVE:":[22],"To":[23],"determine":[24],"the":[25,32,88,94,128,135,159,162,265],"efficacy":[26,225],"and":[27,57],"safety":[28],"of":[29,34,62,77,82,87,96,131,137,141,148,165,197,201,267],"famciclovir":[30,156,181,210,245],"in":[31,55,93,209,214,271],"suppression":[33,266],"recurrent":[35],"HSV":[37,133,142,202,269],"infection.":[38],"DESIGN:":[39],"A":[40,60],"randomized,":[41],"double-blind,":[42],"placebo-controlled,":[43],"parallel-group":[44],"study.":[45],"SETTING:":[46],"Thirty":[47],"university,":[48],"hospital,":[49],"or":[50,72,79,107,113,118,248,254],"private":[51],"outpatient":[52],"referral":[53],"centers":[54],"Canada":[56],"Europe.":[58],"PATIENTS:":[59],"total":[61],"455":[63],"(223":[65],"men,":[66],"232":[67],"women)":[68],"aged":[69],"18":[70],"years":[71],"older":[73],"a":[75],"history":[76],"6":[78,145,219],"more":[80],"episodes":[81],"during":[85],"12":[86,229],"most":[89],"recent":[90],"24":[91],"months,":[92],"absence":[95],"suppressive":[97],"therapy,":[98],"received":[99],"study":[100],"medication.":[101],"INTERVENTION:":[102],"Oral":[103,244],"famciclovir,":[104],"125":[105],"mg":[106,109,115,247,250,256],"250":[108,114,249,255],"3":[110,206,251],"times":[111,207,252],"daily":[112,253],"twice":[116,257],"daily,":[117],"placebo":[119,193,215],"52":[121],"weeks.":[122],"MAIN":[123],"OUTCOME":[124],"MEASURES:":[125],"Time":[126],"to":[127,161,178,185,241],"first":[129,163],"recurrence":[130,143,164,179,203],"infection;":[134],"proportion":[136,196],"remaining":[139,199],"free":[140,200],"at":[144,168,218,228],"months;":[146],"frequency":[147],"adverse":[149,237],"events.":[150],"RESULTS:":[151],"In":[152],"an":[153,236,260],"intent-to-treat":[154],"analysis,":[155],"significantly":[157],"delayed":[158],"time":[160,177],"all":[169],"dose":[170],"regimens":[171],"(hazard":[172],"ratios,":[173],"2.9-3.3;":[174],"P<.001);":[175,224],"median":[176],"recipients":[182,211,216],"was":[183,204,226,232],"222":[184],"336":[186],"days":[187,191],"compared":[188],"47":[190],"recipients.":[194],"The":[195],"approximately":[205],"higher":[208],"(79%-86%)":[212],"than":[213],"(27%)":[217],"months":[220],"(relative":[221],"risks,":[222],"2.9-3.1;":[223],"maintained":[227],"months.":[230],"Famciclovir":[231],"well":[233],"tolerated":[234],"experience":[238],"profile":[239],"comparable":[240],"placebo.":[242],"CONCLUSIONS:":[243],"(125":[246],"daily)":[258],"is":[259],"effective,":[261],"well-tolerated":[262],"treatment":[263],"infection":[270]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}