{"id":"https://openalex.org/W2083778992","doi":"https://doi.org/10.1677/joe.0.1020043","title":"Use of the perifusion technique on rat thyroid fragments in the study of thyroid hormone secretion: short-term effects of thyrotrophin, theophylline and glucagon","display_name":"Use of the perifusion technique on rat thyroid fragments in the study of thyroid hormone secretion: short-term effects of thyrotrophin, theophylline and glucagon","publication_year":1984,"publication_date":"1984-07-01","ids":{"openalex":"https://openalex.org/W2083778992","doi":"https://doi.org/10.1677/joe.0.1020043","mag":"2083778992","pmid":"https://pubmed.ncbi.nlm.nih.gov/6736852"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.1020043","doi":"https://doi.org/10.1677/joe.0.1020043","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1020043","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112153875","display_name":"J R Attali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. R. Attali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111407577","display_name":"Dorian Darnis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Darnis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102920066","display_name":"Paul Elie Valensi","orcid":"https://orcid.org/0000-0002-2475-227X","observed_orcids":["https://orcid.org/0000-0002-2475-227X","https://orcid.org/0000-0003-2398-3188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Valensi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025068679","display_name":"C. Weisselberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Weisselberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113523612","display_name":"J S\u00e9baoun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Sebaoun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7951,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.90078708,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"1","first_page":"43","last_page":"NP"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormone-secretion","display_name":"thyroid hormone secretion","score":0.8849999904632568},{"id":"https://openalex.org/keywords/perifusion","display_name":"perifusion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.8740000128746033},{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.953000009059906},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":1.0},{"id":"https://openalex.org/keywords/thyroid-stimulation","display_name":"thyroid stimulation","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8692504167556763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.864288330078125},{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.8621295690536499},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7358137369155884},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6856405735015869},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6418354511260986},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6388686895370483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4859999120235443}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012636","descriptor_name":"Secretory Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1677/joe.0.1020043","doi":"https://doi.org/10.1677/joe.0.1020043","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1020043","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:6736852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6736852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2411524154","https://openalex.org/W2255569587","https://openalex.org/W1999117461","https://openalex.org/W2020884724","https://openalex.org/W2027258160","https://openalex.org/W1991627841","https://openalex.org/W2078532046","https://openalex.org/W1987923348","https://openalex.org/W2092613703","https://openalex.org/W1984572560"],"abstract_inverted_index":{"Perifusion":[0,137],"of":[1,11,42,82,100,117,138,153,162],"rat":[2,139],"thyroid":[3,17,73,140,170,197],"fragments":[4,141],"was":[5,53,142,191],"performed":[6],"to":[7,23,44,144],"study":[8],"short-term":[9],"effects":[10,152,157],"TSH,":[12,83],"theophylline":[13],"and":[14,27,29,46,72,110,126],"glucagon":[15,194],"on":[16,196],"hormone":[18,119,198],"secretion.":[19],"This":[20],"technique":[21],"proved":[22],"be":[24,145,173],"relatively":[25],"convenient":[26],"sensitive,":[28],"gave":[30],"reproducible":[31],"results":[32,186],"for":[33,149,160,178],"at":[34],"least":[35],"3":[36],"h,":[37],"permitting":[38],"precise":[39],"kinetic":[40],"studies":[41],"response":[43],"hormonal":[45,182],"pharmacological":[47,180],"agents":[48],"without":[49],"any":[50],"interference.":[51],"There":[52],"a":[54,107,122,146,175,192,201],"significant":[55,159],"(P":[56],"less":[57],"than":[58],"0.001)":[59],"linear":[60],"correlation":[61],"between":[62,124],"the":[63,68,79,88,118,134],"log":[64],"TSH":[65,112,135],"concentrations":[66],"over":[67],"range":[69],"20-150":[70],"mu./ml":[71],"response.":[74],"A":[75],"second":[76,176],"stimulation,":[77],"using":[78],"same":[80],"concentration":[81],"did":[84,131],"not":[85,132],"differ":[86],"from":[87],"first":[89],"stimulation":[90],"if":[91],"they":[92],"were":[93,158],"separated":[94],"by":[95],"an":[96,114],"active":[97],"'washing'":[98],"period":[99],"only":[101],"15":[102],"min.":[103,168],"Theophylline":[104],"also":[105,187],"had":[106],"stimulating":[108],"effect":[109,195],"like":[111],"induced":[113],"early":[115],"release":[116],"fraction":[120],"with":[121,200],"peak":[123],"2":[125],"4":[127],"min,":[128],"but":[129],"it":[130],"potentiate":[133],"effect.":[136],"found":[143],"useful":[147],"tool":[148],"analysing":[150],"dynamic":[151],"various":[154],"substances.":[155],"These":[156],"periods":[161],"time":[163,177],"as":[164,166],"short":[165],"20":[167],"Each":[169],"preparation":[171],"could":[172],"used":[174],"another":[179],"or":[181],"test.":[183],"Our":[184],"preliminary":[185],"suggested":[188],"that":[189],"there":[190],"direct":[193],"secretion":[199],"dose-response":[202],"correlation.":[203]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}