{"id":"https://openalex.org/W2083672035","doi":"https://doi.org/10.1677/jme.0.001r005","title":"CONTROL OF IGF-II mRNA LEVELS BY GLUCOCORTICOIDS IN THE NEONATAL RAT","display_name":"CONTROL OF IGF-II mRNA LEVELS BY GLUCOCORTICOIDS IN THE NEONATAL RAT","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2083672035","doi":"https://doi.org/10.1677/jme.0.001r005","mag":"2083672035","pmid":"https://pubmed.ncbi.nlm.nih.gov/3255362"},"language":"en","primary_location":{"id":"doi:10.1677/jme.0.001r005","doi":"https://doi.org/10.1677/jme.0.001r005","is_oa":false,"landing_page_url":"https://doi.org/10.1677/jme.0.001r005","pdf_url":null,"source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013929607","display_name":"Felix Beck","orcid":"https://orcid.org/0000-0003-0420-7060","observed_orcids":["https://orcid.org/0000-0003-0420-7060"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Felix Beck","raw_affiliation_strings":["Department of Anatomy, University of Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Leicester","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614941","display_name":"Nilesh J. Samani","orcid":"https://orcid.org/0000-0002-3286-8133","observed_orcids":["https://orcid.org/0000-0002-3286-8133"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N.J. Samani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111702365","display_name":"Paul Vincent Senior","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Senior","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S. Byrne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Byrne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066742369","display_name":"K. Morgan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R. Gebhard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Gebhard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110135483","display_name":"William J. Brammar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W.J. Brammar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.686,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.93422962,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1","issue":"3","first_page":"R5","last_page":"R8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.921999990940094},{"id":"https://openalex.org/keywords/igf-ii-mrna","display_name":"IGF-II mRNA","score":0.9010000228881836},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cortisone-acetate","display_name":"cortisone acetate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.7900000214576721},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9570000171661377},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.6370000243186951},{"id":"https://openalex.org/keywords/autocrine-paracrine-signaling","display_name":"autocrine and paracrine signaling","score":0.7429999709129333},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8669999837875366},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.6698173880577087},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6466485261917114},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6235642433166504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6104922294616699},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5902640223503113},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5823391079902649},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5263729691505432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5233577489852905},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5179116129875183},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5077506303787231},{"id":"https://openalex.org/C2780484280","wikidata":"https://www.wikidata.org/wiki/Q423185","display_name":"Cortisone","level":2,"score":0.4829839766025543},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.45547839999198914},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.45387616753578186},{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.4496017098426819},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4392777383327484},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3730321228504181},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3726300597190857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20817816257476807},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0952499508857727},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0852399468421936},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07819199562072754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07500436902046204},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002831","descriptor_name":"Choroid Plexus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1677/jme.0.001r005","doi":"https://doi.org/10.1677/jme.0.001r005","is_oa":false,"landing_page_url":"https://doi.org/10.1677/jme.0.001r005","pdf_url":null,"source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:3255362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3255362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1013.5837","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1013.5837","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jme.endocrinology-journals.org/content/1/3/R5.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320276","display_name":"University of Leicester","ror":"https://ror.org/04h699437"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2041448279","https://openalex.org/W2170076134","https://openalex.org/W2038938580","https://openalex.org/W2101333220","https://openalex.org/W4252861601","https://openalex.org/W2091572677","https://openalex.org/W2001312555","https://openalex.org/W2101023528","https://openalex.org/W2092414301","https://openalex.org/W2056617048"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1,10],"factor-II":[2],"(IGF-II)":[3],"is":[4,88,99],"thought":[5],"to":[6],"be":[7],"a":[8],"major":[9,28],"factor":[11],"during":[12],"fetal":[13],"and":[14,36,56,85],"neonatal":[15,72],"development.":[16],"Levels":[17],"of":[18,30,45,104],"IGF-II":[19,67,107],"mRNA":[20,68],"fall":[21],"dramatically":[22],"in":[23,70,101],"the":[24,27,43,71,102,105],"liver":[25],"-":[26,33],"site":[29],"endocrine":[31],"production":[32],"between":[34],"18":[35],"20":[37],"days":[38],"post-natally.":[39],"No":[40],"information":[41],"concerning":[42],"control":[44],"gene":[46,108],"expression":[47,69],"post-natally":[48],"has":[49],"hitherto":[50],"been":[51],"available.":[52],"Using":[53],"Northern":[54],"blotting":[55],"in-situ":[57],"hybridization,":[58],"we":[59],"show":[60],"here":[61],"that":[62],"cortisone":[63,97],"acetate":[64,98],"rapidly":[65],"extinguishes":[66],"rat":[73],"liver.":[74],"The":[75,94],"effect":[76],"at":[77],"putative":[78],"autocrine/paracrine":[79],"locations":[80],"such":[81],"as":[82],"skeletal":[83],"muscle":[84],"choroid":[86],"plexus":[87],"much":[89],"less":[90],"marked":[91],"or":[92],"absent.":[93],"repression":[95],"by":[96],"discussed":[100],"light":[103],"available":[106],"sequence.":[109]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}