{"id":"https://openalex.org/W2083661220","doi":"https://doi.org/10.1515/jpm-2012-0064","title":"Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis","display_name":"Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis","publication_year":2012,"publication_date":"2012-06-24","ids":{"openalex":"https://openalex.org/W2083661220","doi":"https://doi.org/10.1515/jpm-2012-0064","mag":"2083661220","pmid":"https://pubmed.ncbi.nlm.nih.gov/23093080"},"language":"en","primary_location":{"id":"doi:10.1515/jpm-2012-0064","doi":"https://doi.org/10.1515/jpm-2012-0064","is_oa":false,"landing_page_url":"https://doi.org/10.1515/jpm-2012-0064","pdf_url":null,"source":{"id":"https://openalex.org/S61009040","display_name":"Journal of Perinatal Medicine","issn_l":"0300-5577","issn":["0300-5577","1619-3997"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"jpme","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/retrieve/b83e535f-b63c-470b-a886-791078cf1f86","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011431343","display_name":"Michael A. Heesen","orcid":"https://orcid.org/0000-0002-6528-8100","observed_orcids":["https://orcid.org/0000-0002-6528-8100"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Heesen","raw_affiliation_strings":["Department of Anesthesia, Klinikum Bamberg, Bamberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Klinikum Bamberg, Bamberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065703461","display_name":"S. Kl\u00f6hr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sven Kl\u00f6hr","raw_affiliation_strings":["Department of Anesthesia, Klinikum Bamberg, Bamberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Klinikum Bamberg, Bamberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021767295","display_name":"Rolf Rossaint","orcid":"https://orcid.org/0000-0001-7587-1693","observed_orcids":["https://orcid.org/0000-0001-7587-1693"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Rossaint","raw_affiliation_strings":["Department of Anesthesia, Universit\u00e4tsklinkum Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Universit\u00e4tsklinkum Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I4210120689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013215073","display_name":"Sebastian Straube","orcid":"https://orcid.org/0000-0001-7862-0398","observed_orcids":["https://orcid.org/0000-0001-7862-0398"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Straube","raw_affiliation_strings":["Department of Occupational, Social and Environmental Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational, Social and Environmental Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112217860","display_name":"Marc Van de Velde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marc Van de Velde","raw_affiliation_strings":["Department of Anesthesia, Universitair Zieckenhuis Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Universitair Zieckenhuis Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011431343"],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"EUR","value_usd":0},"apc_paid":null,"fwci":0.8757,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.77707663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"40","issue":"6","first_page":"625","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.20389999449253082,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/labor-epidural-analgesia","display_name":"labor epidural analgesia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/maternal-fever","display_name":"maternal fever","score":0.7889999747276306},{"id":"https://openalex.org/keywords/neonatal-sepsis","display_name":"neonatal sepsis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/maternal-hyperthermia","display_name":"maternal hyperthermia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/neonatal-infection","display_name":"neonatal infection","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9595637321472168},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.749396800994873},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.7459216117858887},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7010599374771118},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6717124581336975},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6207199692726135},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5870498418807983},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5677734613418579},{"id":"https://openalex.org/C2775953899","wikidata":"https://www.wikidata.org/wiki/Q6993495","display_name":"Neonatal sepsis","level":3,"score":0.5445362329483032},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4548906981945038},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3808363080024719},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3548611104488373},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35102206468582153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015360","descriptor_name":"Analgesia, Epidural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016362","descriptor_name":"Analgesia, Obstetrical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1515/jpm-2012-0064","doi":"https://doi.org/10.1515/jpm-2012-0064","is_oa":false,"landing_page_url":"https://doi.org/10.1515/jpm-2012-0064","pdf_url":null,"source":{"id":"https://openalex.org/S61009040","display_name":"Journal of Perinatal Medicine","issn_l":"0300-5577","issn":["0300-5577","1619-3997"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"jpme","raw_type":"journal-article"},{"id":"pmid:23093080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23093080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of perinatal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/374192","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/374192","pdf_url":"https://lirias.kuleuven.be/retrieve/b83e535f-b63c-470b-a886-791078cf1f86","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Perinatal Medicine, vol. 40 (6), (625-630)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:goescholar:1/10595","doi":null,"is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/10595","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/25030","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gs-1/10595","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publications.rwth-aachen.de:217156","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/217156","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of perinatal medicine 40(6), 625-630 (2012). doi:10.1515/jpm-2012-0064","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/374192","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/374192","pdf_url":"https://lirias.kuleuven.be/retrieve/b83e535f-b63c-470b-a886-791078cf1f86","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Perinatal Medicine, vol. 40 (6), (625-630)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2083661220.pdf","grobid_xml":"https://content.openalex.org/works/W2083661220.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1527540376","https://openalex.org/W1984029604","https://openalex.org/W2000488239","https://openalex.org/W2002439743","https://openalex.org/W2026936980","https://openalex.org/W2040714198","https://openalex.org/W2051784075","https://openalex.org/W2057108279","https://openalex.org/W2062336399","https://openalex.org/W2066875081","https://openalex.org/W2080039169","https://openalex.org/W2132501718","https://openalex.org/W2142057758","https://openalex.org/W2316949645","https://openalex.org/W2323501524","https://openalex.org/W2332576608","https://openalex.org/W4211053622"],"related_works":["https://openalex.org/W3003560528","https://openalex.org/W2000426934","https://openalex.org/W2168072356","https://openalex.org/W2336410873","https://openalex.org/W2329590134","https://openalex.org/W2953811009","https://openalex.org/W2151501867","https://openalex.org/W2002361262","https://openalex.org/W1968676370","https://openalex.org/W2057108279"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,28,158],"known":[2],"side":[3],"effect":[4],"of":[5,24,36,94,110,149,155,172],"labour":[6],"epidural":[7],"analgesia":[8],"(EDA)":[9],"is":[10,14,161,166],"maternal":[11,142,164],"fever.":[12],"It":[13],"unclear":[15],"whether":[16,162],"this":[17],"has":[18],"effects":[19,66],"on":[20,73],"the":[21,25,64,111,121,124,156],"anti-infectious":[22],"management":[23],"neonate.":[26],"METHODS:":[27],"systematic":[29],"literature":[30],"search":[31,35],"and":[32,56,82,129,152,178],"a":[33],"hand":[34],"abstract":[37],"publications":[38],"were":[39,48,61,76,79,84,132],"conducted.":[40],"Studies":[41],"reporting":[42,72],"sepsis":[43,92,127,150],"evaluation":[44,128],"or":[45],"antibiotic":[46,108,153],"treatment":[47,109,131,154],"further":[49],"assessed.":[50],"For":[51],"meta-analysis,":[52],"risk":[53],"ratio":[54],"(RR)":[55],"95%":[57],"confidence":[58],"interval":[59],"(CI)":[60],"calculated":[62],"using":[63],"random":[65],"model.":[67],"RESULTS:":[68],"Five":[69],"relevant":[70],"articles":[71],"4667":[74],"parturients":[75],"identified;":[77],"three":[78],"observational":[80],"studies":[81,96],"two":[83],"randomised":[85],"controlled":[86],"trials":[87],"(RCT).":[88],"The":[89,105],"RR":[90,106],"for":[91,107,126],"workup":[93,151],"all":[95],"analysed":[97],"together":[98],"was":[99,113],"2.58":[100],"(95%":[101,115],"CI,":[102,116],"1.06-6.27,":[103],"P=0.04).":[104],"neonate":[112],"2.76":[114],"1.20-6.31,":[117],"P=0.02).":[118],"When":[119],"considering":[120],"RCTs":[122],"alone,":[123],"RRs":[125],"antimicrobial":[130],"still":[133],"significantly":[134],"elevated.":[135],"DISCUSSION:":[136],"Our":[137],"data":[138],"suggest":[139],"that":[140],"EDA-related":[141,163],"hyperthermia":[143,165],"results":[144],"in":[145],"an":[146],"increased":[147],"likelihood":[148],"infant.":[157],"crucial":[159],"question":[160],"truly":[167],"infectious.":[168],"If":[169],"not,":[170],"administration":[171],"antibiotics":[173],"would":[174],"not":[175],"be":[176,180],"justified":[177],"may":[179],"dangerous.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
