{"id":"https://openalex.org/W2083644615","doi":"https://doi.org/10.1542/peds.2008-2139cccc","title":"Cutting Edge: Immunosuppressant as Adjuvant for Tolerogenic Immunization","display_name":"Cutting Edge: Immunosuppressant as Adjuvant for Tolerogenic Immunization","publication_year":2008,"publication_date":"2008-10-31","ids":{"openalex":"https://openalex.org/W2083644615","doi":"https://doi.org/10.1542/peds.2008-2139cccc","mag":"2083644615"},"language":"en","primary_location":{"id":"doi:10.1542/peds.2008-2139cccc","doi":"https://doi.org/10.1542/peds.2008-2139cccc","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2008-2139cccc","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057968453","display_name":"Pamela A. Frischmeyer\u2010Guerrerio","orcid":"https://orcid.org/0000-0003-2259-5546","observed_orcids":["https://orcid.org/0000-0003-2259-5546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pamela A. Guerrerio","raw_affiliation_strings":["Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baltimore, MD","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002714937","display_name":"Elizabeth Cotton Matsui","orcid":"https://orcid.org/0000-0001-8134-5593","observed_orcids":["https://orcid.org/0000-0001-8134-5593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth C. Matsui","raw_affiliation_strings":["Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baltimore, MD","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17920092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"Supplement_4","first_page":"S222","last_page":"S223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6740000247955322},{"id":"https://openalex.org/keywords/antigen-specific-tolerance","display_name":"antigen-specific tolerance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.8550000190734863},{"id":"https://openalex.org/keywords/autoimmune-diabetes","display_name":"autoimmune diabetes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/insulin-peptides","display_name":"insulin peptides","score":0.800000011920929},{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.7409999966621399},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.8655680418014526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8604715466499329},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6219340562820435},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5460822582244873},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5121786594390869},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.41661006212234497},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4122401475906372},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4043836295604706},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.33763188123703003},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30551642179489136}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1542/peds.2008-2139cccc","doi":"https://doi.org/10.1542/peds.2008-2139cccc","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2008-2139cccc","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1484290979","https://openalex.org/W24159050","https://openalex.org/W2073498442","https://openalex.org/W4243501797","https://openalex.org/W1582259578","https://openalex.org/W2061225827","https://openalex.org/W2104613583","https://openalex.org/W2104464991","https://openalex.org/W4313359020","https://openalex.org/W3035655661"],"abstract_inverted_index":{"Kang":[0],"Y,":[1],"Xu":[2],"L,":[3],"Wang":[4],"B,":[5],"Chen":[6],"A,":[7],"Zheng":[8],"G.":[9],"J":[10],"Immunol.":[11],"2008;180(8):5172\u20135176":[12],"PURPOSE":[13],"OF":[14],"THE":[15],"STUDY.":[16],"Immunosuppressive":[17],"agents":[18,445],"are":[19,33],"used":[20,70],"frequently":[21],"for":[22,117,172,188,192,310,435],"the":[23,107,135,139,165,314,348,396],"treatment":[24,333],"of":[25,42,73,111,129,211,222,232,251,259,303,316,329,334,341,350,380,387,399,418,450],"allergy,":[26],"autoimmune":[27,233],"disease,":[28],"and":[29,121,137,170,195,238,257,262,326,344,377,402,429],"transplant":[30],"rejection":[31],"but":[32,438],"thought":[34],"to":[35,46,77,96,123,249,282,319,392],"provide":[36],"only":[37],"temporary":[38],"benefit.":[39],"The":[40,68,366,416],"authors":[41,69,417],"this":[43,403,414,419,436],"study":[44,404],"sought":[45],"determine":[47],"if":[48],"dexamethasone,":[49],"a":[50,64,71,86,229,288],"glucocorticoid":[51],"with":[52,63,93,101,158,167,226,267,279,337,347,360],"potent":[53],"immunosuppressive":[54],"properties,":[55],"could":[56],"promote":[57,363,448],"long-term":[58,270,351,364,388],"antigen-specific":[59,263,352,382],"tolerance":[60],"when":[61,357],"administered":[62],"peptide":[65,105],"immunogen.":[66],"METHODS.":[67],"model":[72,231],"delayed-type":[74],"hypersensitivity":[75],"(DTH)":[76],"hen":[78,283],"ovalbumin":[79,83,97,133,168,284,294],"by":[80,131,152,190,235,255,287,300],"subcutaneously":[81],"injecting":[82,132],"twice":[84],"during":[85],"2-week":[87,120],"interval":[88],"into":[89,134],"BALB/c":[90],"mice.":[91],"Mice":[92],"established":[94],"DTH":[95,118,281],"were":[98,115,150,186,216,246],"then":[99],"immunized":[100],"an":[102,239,301],"ovalbumin-derived":[103],"MHCII-restricted":[104,241],"in":[106,141,181,203,277,290,313,323,412,453],"presence":[108,315],"or":[109],"absence":[110],"dexamethasone.":[112],"All":[113],"mice":[114,207,278,336],"retested":[116],"at":[119],"4-":[122],"5-month":[124],"time":[125,248],"points":[126],"after":[127,293,455],"completion":[128],"immunization":[130],"footpad":[136,142],"measuring":[138],"increase":[140],"thickness.":[143],"Blood-derived":[144],"CD4+CD25+Foxp3+":[145,304],"regulatory":[146],"T":[147,214],"cells":[148,157,179,215],"(Tregs)":[149],"quantitated":[151],"labeling":[153],"peripheral":[154],"white":[155],"blood":[156],"carboxyfluorescein":[159],"diacetate":[160],"succinimidyl":[161],"ester":[162],"(CFSE),":[163],"stimulating":[164],"cultures":[166],"peptide,":[169,361],"analyzing":[171],"CFSE":[173],"dilution":[174],"(indicating":[175],"cell":[176],"division).":[177],"Dendritic":[178],"(DCs)":[180],"draining":[182,324],"lymph":[183],"nodes":[184],"(LNs)":[185],"assessed":[187],"maturity":[189],"staining":[191],"CD11c,":[193],"CD83,":[194],"CD86,":[196],"as":[197,199,274,285,390],"well":[198],"interleukin":[200],"10":[201],"(IL-10)":[202],"some":[204,441],"experiments.":[205],"Transgenic":[206],"containing":[208],"large":[209],"numbers":[210,261],"ovalbumin-specific":[212],"CD4+":[213],"studied":[217],"also.":[218],"A":[219],"similar":[220],"set":[221],"experiments":[223],"was":[224,298,345],"performed":[225],"nonobese-diabetic":[227,335],"mice,":[228],"mouse":[230],"diabetes,":[234],"using":[236],"dexamethasone":[237,268,338],"insulin-derived":[240],"peptide.":[242],"Primary":[243],"outcomes":[244],"measured":[245],"median":[247],"development":[250,340,349,379,449],"diabetes":[252,343],"(as":[253,272],"defined":[254],"glycosuria)":[256],"measurement":[258],"Treg":[260],"proliferation.":[264],"RESULTS.":[265],"Treatment":[266],"induced":[269],"desensitization":[271],"long":[273],"4\u20135":[275],"months)":[276],"preestablished":[280],"evidenced":[286],"decrease":[289],"foot-pad":[291],"swelling":[292],"challenge.":[295],"This":[296],"finding":[297],"accompanied":[299],"expansion":[302],"Tregs,":[305],"which":[306],"largely":[307],"had":[308],"specificity":[309],"ovalbumin.":[311],"Dexamethasone,":[312,356],"ovalbumin,":[317],"seemed":[318],"block":[320],"DC":[321,375],"maturation":[322,376],"LNs":[325],"facilitated":[327],"differentiation":[328],"IL-10+":[330],"DCs.":[331],"Furthermore,":[332],"hindered":[339],"spontaneous":[342],"associated":[346],"persistent":[353,381],"Tregs.":[354,383],"CONCLUSIONS.":[355],"applied":[358],"together":[359],"can":[362],"tolerance.":[365],"underlying":[367],"mechanism":[368],"may":[369,408,431,446],"involve":[370],"dexamethasone's":[371],"effect":[372],"on":[373],"inhibiting":[374],"promoting":[378],"REVIEWER":[384],"COMMENTS.":[385],"Development":[386],"tolerance,":[389],"opposed":[391],"transient":[393],"desensitization,":[394],"is":[395,440],"end":[397],"goal":[398],"immunotherapy":[400],"protocols,":[401],"suggests":[405],"that":[406,422,443],"glucocorticoids":[407],"be":[409,433],"effective":[410,434],"adjuvants":[411],"achieving":[413],"goal.":[415],"article":[420],"speculated":[421],"other":[423],"small-molecule":[424],"immunosuppressant":[425],"drugs,":[426],"including":[427],"cyclosporine":[428],"FK506,":[430],"also":[432],"purpose,":[437],"there":[439],"evidence":[442],"these":[444],"actually":[447],"allergic":[451],"disease":[452],"children":[454],"solid":[456],"organ":[457],"transplantation.":[458]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
