{"id":"https://openalex.org/W2083591059","doi":"https://doi.org/10.1016/8756-3282(92)90087-d","title":"Impaired bone activity in aged rats: Alterations at the cellular and molecular levels","display_name":"Impaired bone activity in aged rats: Alterations at the cellular and molecular levels","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W2083591059","doi":"https://doi.org/10.1016/8756-3282(92)90087-d","mag":"2083591059","pmid":"https://pubmed.ncbi.nlm.nih.gov/1476822"},"language":"en","primary_location":{"id":"doi:10.1016/8756-3282(92)90087-d","doi":"https://doi.org/10.1016/8756-3282(92)90087-d","is_oa":false,"landing_page_url":"https://doi.org/10.1016/8756-3282(92)90087-d","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113595058","display_name":"C. T. Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C.T. Liang","raw_affiliation_strings":["Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224","Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071263509","display_name":"Janice Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Barnes","raw_affiliation_strings":["Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085483477","display_name":"J.G. Seedor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.G. Seedor","raw_affiliation_strings":["Merck, Sharp & Dohme Research Laboratories, West Point, PA 19486 U.S.A","Merck, Sharp and Dohme Research Laboratories, West Point, PA, 19486 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck, Sharp & Dohme Research Laboratories, West Point, PA 19486 U.S.A","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck, Sharp and Dohme Research Laboratories, West Point, PA, 19486 U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110163328","display_name":"Helen A. Quartuccio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.A. Quartuccio","raw_affiliation_strings":["Merck, Sharp & Dohme Research Laboratories, West Point, PA 19486 U.S.A","Merck, Sharp and Dohme Research Laboratories, West Point, PA, 19486 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck, Sharp & Dohme Research Laboratories, West Point, PA 19486 U.S.A","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck, Sharp and Dohme Research Laboratories, West Point, PA, 19486 U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077089290","display_name":"Mark E. Bolander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Bolander","raw_affiliation_strings":["Mayo Clinic, Rochester, MN 55905 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN 55905 U.S.A","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011806639","display_name":"John J. Jeffrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77920804","display_name":"Albany Medical Center Hospital","ror":"https://ror.org/0307crw42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I77920804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.J. Jeffrey","raw_affiliation_strings":["Albany Medical Center, Albany, NY 12208 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany Medical Center, Albany, NY 12208 U.S.A","institution_ids":["https://openalex.org/I77920804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042186052","display_name":"Gideon A. Rodan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.A. Rodan","raw_affiliation_strings":["Merck, Sharp & Dohme Research Laboratories, West Point, PA 19486 U.S.A","Merck, Sharp and Dohme Research Laboratories, West Point, PA, 19486 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck, Sharp & Dohme Research Laboratories, West Point, PA 19486 U.S.A","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck, Sharp and Dohme Research Laboratories, West Point, PA, 19486 U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113595058"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":1.4518,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.80807769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"6","first_page":"435","last_page":"441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-aging","display_name":"bone aging","score":0.7020000219345093},{"id":"https://openalex.org/keywords/bone-marrow-ablation","display_name":"bone marrow ablation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":1.0},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bone-volume","display_name":"bone volume","score":0.7440000176429749},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.7210000157356262},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.8179255723953247},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.7716962099075317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7465589046478271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7149933576583862},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.642797589302063},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5688193440437317},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.532655656337738},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.5196515321731567},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5066984295845032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4073122441768646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3369836211204529},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.33425235748291016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2777233123779297},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08143320679664612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06373932957649231},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011347","descriptor_name":"Procollagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/8756-3282(92)90087-d","doi":"https://doi.org/10.1016/8756-3282(92)90087-d","is_oa":false,"landing_page_url":"https://doi.org/10.1016/8756-3282(92)90087-d","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},{"id":"pmid:1476822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1476822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W181180602","https://openalex.org/W1532387473","https://openalex.org/W1561293749","https://openalex.org/W1564677921","https://openalex.org/W1574889830","https://openalex.org/W1964491329","https://openalex.org/W1965174761","https://openalex.org/W1967709376","https://openalex.org/W1974990647","https://openalex.org/W1977907775","https://openalex.org/W1997097878","https://openalex.org/W1997355841","https://openalex.org/W2010359869","https://openalex.org/W2015295890","https://openalex.org/W2025923256","https://openalex.org/W2026841478","https://openalex.org/W2035380915","https://openalex.org/W2036693613","https://openalex.org/W2037156287","https://openalex.org/W2046983302","https://openalex.org/W2049160624","https://openalex.org/W2065381287","https://openalex.org/W2068537168","https://openalex.org/W2077123614","https://openalex.org/W2081165103","https://openalex.org/W2091683052","https://openalex.org/W2093833911","https://openalex.org/W2108409970","https://openalex.org/W2132309525","https://openalex.org/W2134709004","https://openalex.org/W2166935415"],"related_works":["https://openalex.org/W2068655473","https://openalex.org/W2608899983","https://openalex.org/W1983577624","https://openalex.org/W2481830351","https://openalex.org/W2037735580","https://openalex.org/W4249442788","https://openalex.org/W2090855715","https://openalex.org/W2417828575","https://openalex.org/W2444244053","https://openalex.org/W2061443387"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
