{"id":"https://openalex.org/W2083423337","doi":"https://doi.org/10.1097/00005392-199707000-00004","title":"The Relationship Between Prostatic Intraepithelial Neoplasia and Prostate Cancer: Critical Issues","display_name":"The Relationship Between Prostatic Intraepithelial Neoplasia and Prostate Cancer: Critical Issues","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W2083423337","doi":"https://doi.org/10.1097/00005392-199707000-00004","mag":"2083423337","pmid":"https://pubmed.ncbi.nlm.nih.gov/9186314"},"language":"en","primary_location":{"id":"doi:10.1097/00005392-199707000-00004","doi":"https://doi.org/10.1097/00005392-199707000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005392-199707000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031666641","display_name":"Michael H\u00e4ggman","orcid":"https://orcid.org/0000-0001-7234-2534","observed_orcids":["https://orcid.org/0000-0001-7234-2534"]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Michael J. Haggman","raw_affiliation_strings":["From the Michigan Prostate Institute and Department of Pathology, University of Michigan, Ann Arbor, Michigan, and Department of Urology, Uppsala University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Michigan Prostate Institute and Department of Pathology, University of Michigan, Ann Arbor, Michigan, and Department of Urology, Uppsala University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035","https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066248850","display_name":"Jill A. Macoska","orcid":"https://orcid.org/0000-0001-8471-2221","observed_orcids":["https://orcid.org/0000-0001-8471-2221"]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Jill A. Macoska","raw_affiliation_strings":["From the Michigan Prostate Institute and Department of Pathology, University of Michigan, Ann Arbor, Michigan, and Department of Urology, Uppsala University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Michigan Prostate Institute and Department of Pathology, University of Michigan, Ann Arbor, Michigan, and Department of Urology, Uppsala University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035","https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113697530","display_name":"Kirk J. Wojno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Kirk J. Wojno","raw_affiliation_strings":["From the Michigan Prostate Institute and Department of Pathology, University of Michigan, Ann Arbor, Michigan, and Department of Urology, Uppsala University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Michigan Prostate Institute and Department of Pathology, University of Michigan, Ann Arbor, Michigan, and Department of Urology, Uppsala University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035","https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109571053","display_name":"Joseph E. Oesterling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Joseph E. Oesterling","raw_affiliation_strings":["From the Michigan Prostate Institute and Department of Pathology, University of Michigan, Ann Arbor, Michigan, and Department of Urology, Uppsala University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Michigan Prostate Institute and Department of Pathology, University of Michigan, Ann Arbor, Michigan, and Department of Urology, Uppsala University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035","https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.2624,"has_fulltext":false,"cited_by_count":167,"citation_normalized_percentile":{"value":0.91170431,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"158","issue":"1","first_page":"12","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostatic-intraepithelial-neoplasia","display_name":"prostatic intraepithelial neoplasia","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.9380000233650208},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.6570000052452087},{"id":"https://openalex.org/keywords/dna-ploidy","display_name":"DNA ploidy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/high-grade-pin","display_name":"high-grade PIN","score":0.6610000133514404},{"id":"https://openalex.org/keywords/prostate-cancer-risk","display_name":"prostate cancer risk","score":0.44699999690055847},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.6190000176429749},{"id":"https://openalex.org/keywords/localized-prostate-cancer","display_name":"localized prostate cancer","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9468966722488403},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.8216128945350647},{"id":"https://openalex.org/C2776456063","wikidata":"https://www.wikidata.org/wiki/Q15731388","display_name":"High-grade prostatic intraepithelial neoplasia","level":5,"score":0.7290247678756714},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6711915731430054},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5395746231079102},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5225505232810974},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.41500788927078247},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39847731590270996},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3674467206001282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29638370871543884}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D019048","descriptor_name":"Prostatic Intraepithelial Neoplasia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D019048","descriptor_name":"Prostatic Intraepithelial Neoplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019048","descriptor_name":"Prostatic Intraepithelial Neoplasia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005392-199707000-00004","doi":"https://doi.org/10.1097/00005392-199707000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005392-199707000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:9186314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9186314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2505227339","display_name":"ANALYSIS OF 8P LOSS IN HUMAN PROSTATE CANCER","funder_award_id":"5r29ca060948-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7030128301","display_name":null,"funder_award_id":"R29CA 60948-02","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":172,"referenced_works":["https://openalex.org/W2863643","https://openalex.org/W11097077","https://openalex.org/W25591775","https://openalex.org/W31616992","https://openalex.org/W106733404","https://openalex.org/W119164278","https://openalex.org/W144340857","https://openalex.org/W148451655","https://openalex.org/W156989694","https://openalex.org/W180008295","https://openalex.org/W1220153186","https://openalex.org/W1483323966","https://openalex.org/W1508662384","https://openalex.org/W1538847424","https://openalex.org/W1541480589","https://openalex.org/W1542650004","https://openalex.org/W1546572788","https://openalex.org/W1557735298","https://openalex.org/W1563832763","https://openalex.org/W1571487648","https://openalex.org/W1571849492","https://openalex.org/W1576321535","https://openalex.org/W1578881282","https://openalex.org/W1587842942","https://openalex.org/W1595222477","https://openalex.org/W1659313179","https://openalex.org/W1865050205","https://openalex.org/W1899077318","https://openalex.org/W1907850886","https://openalex.org/W1963515202","https://openalex.org/W1965735950","https://openalex.org/W1966159820","https://openalex.org/W1967819851","https://openalex.org/W1971874426","https://openalex.org/W1972609825","https://openalex.org/W1975270142","https://openalex.org/W1979345358","https://openalex.org/W1980977659","https://openalex.org/W1981407964","https://openalex.org/W1981899035","https://openalex.org/W1982509806","https://openalex.org/W1983910334","https://openalex.org/W1984989494","https://openalex.org/W1985168450","https://openalex.org/W1986550738","https://openalex.org/W1987803451","https://openalex.org/W1991874806","https://openalex.org/W1996388835","https://openalex.org/W1999803087","https://openalex.org/W1999864225","https://openalex.org/W2002065284","https://openalex.org/W2002846943","https://openalex.org/W2002902917","https://openalex.org/W2002931312","https://openalex.org/W2003701897","https://openalex.org/W2003851518","https://openalex.org/W2004354003","https://openalex.org/W2006505155","https://openalex.org/W2010424792","https://openalex.org/W2012924225","https://openalex.org/W2014624725","https://openalex.org/W2018577003","https://openalex.org/W2018596412","https://openalex.org/W2018848735","https://openalex.org/W2025610386","https://openalex.org/W2028009279","https://openalex.org/W2031856439","https://openalex.org/W2034021635","https://openalex.org/W2035244457","https://openalex.org/W2037542828","https://openalex.org/W2039259884","https://openalex.org/W2045225395","https://openalex.org/W2045644088","https://openalex.org/W2046063243","https://openalex.org/W2047259044","https://openalex.org/W2049822055","https://openalex.org/W2052044570","https://openalex.org/W2053670125","https://openalex.org/W2054486077","https://openalex.org/W2056609191","https://openalex.org/W2057799790","https://openalex.org/W2058009055","https://openalex.org/W2058893227","https://openalex.org/W2060516639","https://openalex.org/W2062987072","https://openalex.org/W2063207344","https://openalex.org/W2064028125","https://openalex.org/W2068825839","https://openalex.org/W2072081476","https://openalex.org/W2072156172","https://openalex.org/W2073232639","https://openalex.org/W2075280711","https://openalex.org/W2075675819","https://openalex.org/W2077409718","https://openalex.org/W2083995483","https://openalex.org/W2084197013","https://openalex.org/W2087353298","https://openalex.org/W2089426804","https://openalex.org/W2098436713","https://openalex.org/W2100376511","https://openalex.org/W2102590970","https://openalex.org/W2104957990","https://openalex.org/W2117334458","https://openalex.org/W2124140127","https://openalex.org/W2125104077","https://openalex.org/W2130404651","https://openalex.org/W2131287825","https://openalex.org/W2134690493","https://openalex.org/W2135640809","https://openalex.org/W2139062667","https://openalex.org/W2140417252","https://openalex.org/W2147543618","https://openalex.org/W2147942413","https://openalex.org/W2154212618","https://openalex.org/W2157714026","https://openalex.org/W2164777007","https://openalex.org/W2168884694","https://openalex.org/W2225416664","https://openalex.org/W2235954515","https://openalex.org/W2289876362","https://openalex.org/W2315083931","https://openalex.org/W2320682171","https://openalex.org/W2322348418","https://openalex.org/W2324251071","https://openalex.org/W2326379396","https://openalex.org/W2330138758","https://openalex.org/W2334696277","https://openalex.org/W2396068614","https://openalex.org/W2400036618","https://openalex.org/W2400762825","https://openalex.org/W2404819116","https://openalex.org/W2404912181","https://openalex.org/W2405521850","https://openalex.org/W2406509798","https://openalex.org/W2406638291","https://openalex.org/W2407415728","https://openalex.org/W2407535820","https://openalex.org/W2410895990","https://openalex.org/W2411174434","https://openalex.org/W2413099559","https://openalex.org/W2413116478","https://openalex.org/W2413966905","https://openalex.org/W2416967238","https://openalex.org/W2418585789","https://openalex.org/W2418678350","https://openalex.org/W2419415001","https://openalex.org/W2419472164","https://openalex.org/W2422074834","https://openalex.org/W2426474169","https://openalex.org/W2432290759","https://openalex.org/W2437327347","https://openalex.org/W2467237408","https://openalex.org/W2473305333","https://openalex.org/W2481932446","https://openalex.org/W2756314001","https://openalex.org/W3149812034","https://openalex.org/W4230346382","https://openalex.org/W4233108145","https://openalex.org/W4297926144","https://openalex.org/W6604886521","https://openalex.org/W6607337113","https://openalex.org/W6632479695","https://openalex.org/W6633805759","https://openalex.org/W6634063261","https://openalex.org/W6634868798","https://openalex.org/W6635200458","https://openalex.org/W6648350475","https://openalex.org/W6666292221","https://openalex.org/W6670005920","https://openalex.org/W6674818401","https://openalex.org/W6679658159","https://openalex.org/W6680771590"],"related_works":["https://openalex.org/W2401151784","https://openalex.org/W2030939881","https://openalex.org/W2467907681","https://openalex.org/W1989561420","https://openalex.org/W169164502","https://openalex.org/W2415375172","https://openalex.org/W2187482358","https://openalex.org/W1988887061","https://openalex.org/W2010537890","https://openalex.org/W2005081246"],"abstract_inverted_index":{"PURPOSE:":[0],"Prostatic":[1],"intraepithelial":[2],"neoplasia":[3,186],"(PIN)":[4],"is":[5,93,180,221,231,236],"often":[6],"considered":[7],"to":[8,99,119,211,214,240],"be":[9,120,132],"a":[10,32,201,237,244],"premalignant":[11,33],"lesion":[12,34,239],"and":[13,28,35,53,59,92,105,125,159,187,223,249,254],"the":[14,21,25,39,86,90,148,153,183,217],"main":[15],"precursor":[16,238],"of":[17,20,42,49,57,60,89,116,163,165,176,185,247,260],"invasive":[18],"carcinoma":[19],"prostate.":[22],"We":[23],"evaluated":[24],"evidence":[26,56,162,233],"for":[27,38,204,272,275],"against":[29],"PIN":[30,64,104,117,146,160,177,192,235,248,263],"as":[31,151],"determined":[36],"guidelines":[37],"clinical":[40,61,174],"management":[41],"PIN.":[43],"MATERIALS":[44],"AND":[45],"METHODS:":[46],"Literature":[47,67],"analysis":[48],"histopathological,":[50],"morphometric,":[51],"phenotypic":[52],"molecular":[54],"genetic":[55],"progression":[58],"findings":[62,179],"regarding":[63],"was":[65],"done.":[66],"searches":[68],"were":[69],"performed":[70],"on":[71,170,182],"MEDLINE":[72],"with":[73,243],"relevant":[74],"key":[75],"words.":[76],"RESULTS:":[77],"PIN,":[78],"like":[79],"prostate":[80,91,100,106,123,136,155,188,198,205,241,250,277],"cancer,":[81,242],"occurs":[82],"most":[83],"frequently":[84],"in":[85,96,114,145,152,193,207,252,267],"peripheral":[87],"zone":[88],"usually":[94],"located":[95],"close":[97,245],"proximity":[98],"cancer.":[101,156,189,278],"The":[102,173],"relative":[103],"cancer":[107,124,137,158,199,206,251],"volumes":[108],"vary":[109],"inversely.":[110],"Prostate":[111,157],"specific":[112],"antigen":[113],"cases":[115],"appears":[118],"intermediate":[121],"between":[122],"normal":[126],"levels,":[127],"although":[128],"this":[129],"elevation":[130],"may":[131],"explained":[133],"by":[134],"concomitant":[135,154,197],"or":[138],"benign":[139],"prostatic":[140],"hyperplasia.":[141],"Deoxyribonucleic":[142],"acid":[143],"ploidy":[144],"follows":[147],"aneuploid":[149],"proportion":[150],"show":[161],"loss":[164],"putative":[166],"tumor":[167],"suppressor":[168],"genes":[169],"chromosome":[171],"8p.":[172],"relevance":[175],"biopsy":[178,227,253,258],"based":[181],"association":[184,246],"High":[190],"grade":[191,262],"core":[194],"biopsies":[195,209],"without":[196],"has":[200],"substantial":[202],"risk":[203],"subsequent":[208],"(24":[210],"73%,":[212],"up":[213],"100%":[215],"when":[216],"digital":[218],"rectal":[219],"examination":[220],"suspicious)":[222],"should":[224],"cause":[225],"further":[226,265],"sampling.":[228],"CONCLUSIONS:":[229],"There":[230],"convincing":[232],"that":[234],"prostatectomy":[255],"specimens.":[256],"A":[257],"finding":[259],"high":[261],"necessitates":[264],"investigation":[266],"patients":[268],"who":[269],"are":[270],"candidates":[271],"radical":[273],"treatment":[274],"localized":[276]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
