{"id":"https://openalex.org/W2083381256","doi":"https://doi.org/10.1097/01.mpa.0000335426.58851.1a","title":"DOES GEMZAR IMPROVE SURVIVAL IN RESECTED PANCREATIC CANCER PATIENTS?","display_name":"DOES GEMZAR IMPROVE SURVIVAL IN RESECTED PANCREATIC CANCER PATIENTS?","publication_year":2008,"publication_date":"2008-10-22","ids":{"openalex":"https://openalex.org/W2083381256","doi":"https://doi.org/10.1097/01.mpa.0000335426.58851.1a","mag":"2083381256"},"language":"en","primary_location":{"id":"doi:10.1097/01.mpa.0000335426.58851.1a","doi":"https://doi.org/10.1097/01.mpa.0000335426.58851.1a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpa.0000335426.58851.1a","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078270940","display_name":"Vasiliki Androutsopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Androutsopoulos","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Dominguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Dominguez","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061627885","display_name":"Cristina Rosa Ferrone","orcid":"https://orcid.org/0000-0002-6295-1085","observed_orcids":["https://orcid.org/0000-0002-6295-1085"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Ferrone","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019690020","display_name":"Carlos F. Fernandez-del Castillo","orcid":"https://orcid.org/0000-0001-5975-7225","observed_orcids":["https://orcid.org/0000-0001-5975-7225"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Fern\u00e1ndez-del Castillo","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009676742","display_name":"Andrew Louis Warshaw","orcid":"https://orcid.org/0000-0001-7788-3110","observed_orcids":["https://orcid.org/0000-0001-7788-3110"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. L. Warshaw","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056158754","display_name":"Sarah P. Thayer","orcid":"https://orcid.org/0000-0002-4719-5197","observed_orcids":["https://orcid.org/0000-0002-4719-5197"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. P. Thayer","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20981736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"4","first_page":"459","last_page":"459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pancreatic-cancer-surgery","display_name":"pancreatic cancer surgery","score":0.8399999737739563},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.746999979019165},{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.8840000033378601},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.9328697919845581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8548874855041504},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6484165787696838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6127175092697144},{"id":"https://openalex.org/C2777154038","wikidata":"https://www.wikidata.org/wiki/Q7168585","display_name":"Perineural invasion","level":3,"score":0.6049296259880066},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48174381256103516},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.47001034021377563},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.45113450288772583},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.4492626190185547},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.42785772681236267},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3974139392375946},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3605521619319916},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35881149768829346},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.152642160654068}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.mpa.0000335426.58851.1a","doi":"https://doi.org/10.1097/01.mpa.0000335426.58851.1a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpa.0000335426.58851.1a","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072048226","https://openalex.org/W2939329546","https://openalex.org/W2335395227","https://openalex.org/W3007872917","https://openalex.org/W2005070939","https://openalex.org/W4383710943","https://openalex.org/W2590557446","https://openalex.org/W2138582833","https://openalex.org/W1546194171","https://openalex.org/W2162067282"],"abstract_inverted_index":{"Background:":[0],"In":[1],"1996":[2],"Gemcitabine":[3,211,224,244],"(G)":[4],"emerged":[5],"as":[6,212],"a":[7,102,131,150,218],"treatment":[8,78,215],"for":[9,53,66],"pancreatic":[10,250],"cancer.":[11,251],"One":[12],"decade":[13],"has":[14],"elapsed":[15],"since":[16],"its":[17],"institution.":[18],"The":[19,84,208],"aim":[20],"of":[21,73,91,104,152,210],"the":[22,67],"study":[23,241],"is":[24,245],"to":[25,39,124],"detect":[26],"whether":[27],"adjuvant":[28,74,214,248],"G":[29,118,159],"improves":[30],"survival.":[31,223],"Methods:":[32],"A":[33],"prospective":[34],"surgical":[35],"database":[36],"from":[37],"1985":[38],"2007":[40],"with":[41,79,101,149,164,177,231],"1637":[42],"records":[43],"was":[44,95],"reviewed":[45],"and":[46,57,60,76,87,98,144],"identified":[47,111],"579":[48],"patients":[49,93,163,230],"who":[50,116],"underwent":[51],"resection":[52],"PDAC.":[54],"Median,":[55],"mean":[56,103,151],"1,":[58,85],"3,":[59],"5":[61,88],"year":[62,89],"survival":[63,90,136,161],"were":[64,110,167],"calculated":[65],"entire":[68],"group;":[69],"by":[70,77],"decades":[71],"regardless":[72],"treatment;":[75],"or":[80,196,237],"without":[81],"G.":[82],"Results:":[83],"3":[86],"resected":[92],"(579)":[94],"66,":[96],"26":[97],"15%":[99],"respectively,":[100],"30.8":[105],"mo.":[106],"No":[107],"significant":[108,133,220],"differences":[109],"over":[112],"two":[113],"decades.":[114],"Patients":[115],"received":[117],"(n":[119,126],"=":[120,127],"199,":[121],"34.5%)":[122],"compared":[123],"NG":[125],"379,":[128],"65.6%)":[129],"had":[130],"statistically":[132,219],"increase":[134,221],"in":[135,162,217,222,229,249],"at":[137],"1(80":[138],"vs.":[139,142,146,154,172,182,191,202],"55%),":[140],"3(35":[141],"20%)":[143],"5(20":[145],"12%)":[147],"years,":[148],"37":[153],"27.6":[155],"(p":[156],"<":[157,175,185,194,205],"0.0001).":[158,206],"improved":[160],"tumors":[165],"that":[166,243],"moderately":[168,232],"differentiated":[169,233],"(mean":[170,180,189,200],"36.5":[171],"25.5,":[173],"p":[174,184,193,204],"0.0007),":[176],"perineural":[178],"invasion":[179,188],"32.9":[181],"23.6,":[183],"0.0001),":[186],"vascular":[187],"30.1":[190],"17.2,":[192],"0.0001)":[195],"(+)":[197,238],"lymph":[198],"nodes":[199],"28.6":[201],"20.2,":[203],"Conclusion:":[207],"addition":[209],"an":[213,246],"resulted":[216],"may":[225],"be":[226],"particularly":[227],"important":[228],"tumors,":[234],"LVI,":[235],"PNI,":[236],"LNs.":[239],"This":[240],"suggests":[242],"effective":[247]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
