{"id":"https://openalex.org/W2083379121","doi":"https://doi.org/10.1016/j.expneurol.2006.02.040","title":"Effects of alterations of GAD by lentivirus mediated gene transfer on seizure severity in genetically epilepsy prone rats","display_name":"Effects of alterations of GAD by lentivirus mediated gene transfer on seizure severity in genetically epilepsy prone rats","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2083379121","doi":"https://doi.org/10.1016/j.expneurol.2006.02.040","mag":"2083379121"},"language":"en","primary_location":{"id":"doi:10.1016/j.expneurol.2006.02.040","doi":"https://doi.org/10.1016/j.expneurol.2006.02.040","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2006.02.040","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022851788","display_name":"S. Alisha Epps","orcid":"https://orcid.org/0000-0003-1422-4569","observed_orcids":["https://orcid.org/0000-0003-1422-4569"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.A. Epps","raw_affiliation_strings":["Department of Psychology, University of South Carolina, Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of South Carolina, Columbia, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001574183","display_name":"D.E. Venable","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.E. Venable","raw_affiliation_strings":["Department of Psychology, University of South Carolina, Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of South Carolina, Columbia, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008485575","display_name":"Carl L. Faingold","orcid":"https://orcid.org/0000-0002-3666-9991","observed_orcids":["https://orcid.org/0000-0002-3666-9991"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.L. Faingold","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, USA","institution_ids":["https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091250889","display_name":"Steven P. Wilson","orcid":"https://orcid.org/0000-0001-8778-946X","observed_orcids":["https://orcid.org/0000-0001-8778-946X"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.P. Wilson","raw_affiliation_strings":["Department of Pharmacology, Physiology, and Neuroscience, School of Medicine, University of South Carolina, Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Neuroscience, School of Medicine, University of South Carolina, Columbia, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049593057","display_name":"James R. Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.R. Coleman","raw_affiliation_strings":["Department of Pharmacology, Physiology, and Neuroscience, School of Medicine, University of South Carolina, Columbia, USA","Department of Psychology, University of South Carolina, Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Neuroscience, School of Medicine, University of South Carolina, Columbia, USA","institution_ids":["https://openalex.org/I155781252"]},{"raw_affiliation_string":"Department of Psychology, University of South Carolina, Columbia, USA","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":0.2212,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57221073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"198","issue":"2","first_page":"568","last_page":"568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gad","display_name":"GAD","score":0.5979999899864197},{"id":"https://openalex.org/keywords/glutamic-acid-decarboxylase","display_name":"glutamic acid decarboxylase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/lentivirus-mediated-gene-transfer","display_name":"lentivirus-mediated gene transfer","score":0.7590000033378601},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.5189999938011169},{"id":"https://openalex.org/keywords/seizure-severity","display_name":"seizure severity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/genetically-epilepsy-prone-rats","display_name":"genetically epilepsy-prone rats","score":0.921999990940094},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.6700000166893005},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7775046825408936},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.48353099822998047},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4787651598453522},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4373432993888855},{"id":"https://openalex.org/C51456166","wikidata":"https://www.wikidata.org/wiki/Q182726","display_name":"Genetically modified organism","level":3,"score":0.4195624887943268},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.417567640542984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3893916606903076},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3623971939086914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3524342179298401},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27522486448287964},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15823686122894287},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.11892956495285034},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.expneurol.2006.02.040","doi":"https://doi.org/10.1016/j.expneurol.2006.02.040","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2006.02.040","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7101192158","https://openalex.org/W2902255519","https://openalex.org/W1992137883","https://openalex.org/W1987862733","https://openalex.org/W2775300610","https://openalex.org/W4301448043","https://openalex.org/W2016198339","https://openalex.org/W7093878643","https://openalex.org/W2396309155","https://openalex.org/W1965908784"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2016-06-24T00:00:00"}