{"id":"https://openalex.org/W2083373669","doi":"https://doi.org/10.1097/prs.0b013e3181af010c","title":"Preparation and Integration of Human Amnion Nerve Conduits Using a Light-Activated Technique","display_name":"Preparation and Integration of Human Amnion Nerve Conduits Using a Light-Activated Technique","publication_year":2009,"publication_date":"2009-07-29","ids":{"openalex":"https://openalex.org/W2083373669","doi":"https://doi.org/10.1097/prs.0b013e3181af010c","mag":"2083373669","pmid":"https://pubmed.ncbi.nlm.nih.gov/19644257"},"language":"en","primary_location":{"id":"doi:10.1097/prs.0b013e3181af010c","doi":"https://doi.org/10.1097/prs.0b013e3181af010c","is_oa":false,"landing_page_url":"https://doi.org/10.1097/prs.0b013e3181af010c","pdf_url":null,"source":{"id":"https://openalex.org/S100736837","display_name":"Plastic & Reconstructive Surgery","issn_l":"0032-1052","issn":["0032-1052","1076-5751","1529-4242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071090270","display_name":"Anne C. O\u2019Neill","orcid":"https://orcid.org/0000-0002-8036-2866","observed_orcids":["https://orcid.org/0000-0002-8036-2866"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne C. O\u02bcNeill","raw_affiliation_strings":["the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048238441","display_name":"Mark A. Randolph","orcid":"https://orcid.org/0000-0003-0877-9832","observed_orcids":["https://orcid.org/0000-0003-0877-9832"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Randolph","raw_affiliation_strings":["the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008756372","display_name":"Kenneth E. Bujold","orcid":"https://orcid.org/0000-0001-8807-8993","observed_orcids":["https://orcid.org/0000-0001-8807-8993"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E. Bujold","raw_affiliation_strings":["the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033699079","display_name":"Irene E. Kochevar","orcid":"https://orcid.org/0000-0002-3763-3923","observed_orcids":["https://orcid.org/0000-0002-3763-3923"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene E. Kochevar","raw_affiliation_strings":["the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025194131","display_name":"Robert W. Redmond","orcid":"https://orcid.org/0000-0001-8194-430X","observed_orcids":["https://orcid.org/0000-0001-8194-430X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Redmond","raw_affiliation_strings":["the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047195948","display_name":"Jonathan M. Winograd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Winograd","raw_affiliation_strings":["the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Plastic Surgery Research Laboratory and the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9372,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.69861826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"124","issue":"2","first_page":"428","last_page":"437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.08250000327825546,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12906","display_name":"Surgical Sutures and Adhesives","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-amnion","display_name":"human amnion","score":0.7179999947547913},{"id":"https://openalex.org/keywords/nerve-guidance-conduits","display_name":"nerve conduits","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sciatic-nerve-gap","display_name":"sciatic nerve gap","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nerve-repair","display_name":"nerve repair","score":0.5849999785423279},{"id":"https://openalex.org/keywords/autologous-nerve-graft","display_name":"autologous nerve graft","score":0.765999972820282},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2780646683","wikidata":"https://www.wikidata.org/wiki/Q473749","display_name":"Amnion","level":4,"score":0.9039833545684814},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6768091320991516},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.548459529876709},{"id":"https://openalex.org/C136940099","wikidata":"https://www.wikidata.org/wiki/Q6996839","display_name":"Nerve guidance conduit","level":3,"score":0.4384949505329132},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4253539443016052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3807256817817688},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36123162508010864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21087515354156494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11515629291534424},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10147270560264587},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000650","descriptor_name":"Amnion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009416","descriptor_name":"Nerve Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/prs.0b013e3181af010c","doi":"https://doi.org/10.1097/prs.0b013e3181af010c","is_oa":false,"landing_page_url":"https://doi.org/10.1097/prs.0b013e3181af010c","pdf_url":null,"source":{"id":"https://openalex.org/S100736837","display_name":"Plastic & Reconstructive Surgery","issn_l":"0032-1052","issn":["0032-1052","1076-5751","1529-4242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery","raw_type":"journal-article"},{"id":"pmid:19644257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19644257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and reconstructive surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338279","display_name":"Air Force Office of Scientific Research","ror":"https://ror.org/011e9bt93"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W174992002","https://openalex.org/W1524134332","https://openalex.org/W1971996334","https://openalex.org/W1972729557","https://openalex.org/W1980250145","https://openalex.org/W1981225176","https://openalex.org/W1983766316","https://openalex.org/W1996436631","https://openalex.org/W2000274105","https://openalex.org/W2000335778","https://openalex.org/W2026709323","https://openalex.org/W2028438078","https://openalex.org/W2034796772","https://openalex.org/W2048254581","https://openalex.org/W2048903275","https://openalex.org/W2049393475","https://openalex.org/W2056681748","https://openalex.org/W2073677041","https://openalex.org/W2077541188","https://openalex.org/W2079242138","https://openalex.org/W2079816278","https://openalex.org/W2081272290","https://openalex.org/W2087411371","https://openalex.org/W2088579171","https://openalex.org/W2088608292","https://openalex.org/W2090231589","https://openalex.org/W2091510034","https://openalex.org/W2093531961","https://openalex.org/W2096213631","https://openalex.org/W2106068848","https://openalex.org/W2134879734","https://openalex.org/W2161540836","https://openalex.org/W2171956114","https://openalex.org/W2406603782","https://openalex.org/W2413536852"],"related_works":["https://openalex.org/W2432840207","https://openalex.org/W2475237209","https://openalex.org/W2000274105","https://openalex.org/W1983766316","https://openalex.org/W2610235201","https://openalex.org/W4407225395","https://openalex.org/W4384948572","https://openalex.org/W2746290186","https://openalex.org/W2044662985","https://openalex.org/W2076665630"],"abstract_inverted_index":{"BACKGROUND:":[0],"Photochemical":[1,63,151],"tissue":[2,14,24,42,86,121,166],"bonding":[3,25,43,167],"is":[4],"a":[5,157],"developing":[6],"light-activated":[7,53],"technique":[8],"that":[9,20,52,129,144],"facilitates":[10],"watertight":[11],"sealing":[12,21,36],"between":[13],"surfaces.":[15],"Previous":[16],"work":[17],"has":[18],"shown":[19],"with":[22,40,80,136,164],"photochemical":[23,41,85,120,165],"can":[26],"improve":[27],"regeneration":[28,57],"following":[29],"primary":[30],"nerve":[31,38,60,72,90,148,158],"repair.":[32],"The":[33,49],"authors":[34,50],"evaluated":[35],"of":[37,109,161],"stumps":[39],"within":[44,118],"customized":[45],"human":[46],"amnion":[47,65,123,133,153],"conduits.":[48],"hypothesized":[51],"integration":[54],"could":[55],"enhance":[56],"across":[58,69],"the":[59,95,119,132,146,170],"gap.":[61],"METHODS:":[62],"crosslinked":[64,152],"conduits":[66,163],"were":[67,92,114],"placed":[68],"1-cm":[70],"sciatic":[71],"gaps":[73],"in":[74,94,131,145],"Sprague-Dawley":[75],"rats":[76],"and":[77,107,111,138],"either":[78],"secured":[79,135],"sutures":[81,137],"or":[82],"sealed":[83],"using":[84],"bonding.":[87],"Reversed":[88],"autologous":[89,147],"grafts":[91],"used":[93],"control":[96],"group.":[97],"Functional":[98],"recovery":[99],"was":[100,125],"measured":[101],"by":[102],"walking":[103],"track":[104],"analysis;":[105],"histology":[106],"histomorphometry":[108],"nerves":[110],"gastrocnemius":[112],"muscles":[113],"evaluated.":[115],"RESULTS:":[116],"Regeneration":[117],"bonding-sealed":[122],"conduit":[124,134],"significantly":[126,142],"better":[127],"than":[128],"observed":[130],"did":[139],"not":[140],"differ":[141],"from":[143],"graft.":[149],"CONCLUSIONS:":[150],"appears":[154],"suitable":[155],"as":[156],"conduit.":[159],"Sealing":[160],"compatible":[162],"may":[168],"have":[169],"potential":[171],"to":[172],"maximize":[173],"regeneration.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
