{"id":"https://openalex.org/W2083288593","doi":"https://doi.org/10.1210/jc.2004-0724","title":"FGF-23 Is Elevated by Chronic Hyperphosphatemia","display_name":"FGF-23 Is Elevated by Chronic Hyperphosphatemia","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2083288593","doi":"https://doi.org/10.1210/jc.2004-0724","mag":"2083288593","pmid":"https://pubmed.ncbi.nlm.nih.gov/15356053"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2004-0724","doi":"https://doi.org/10.1210/jc.2004-0724","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2004-0724","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101782873","display_name":"Anurodh Gupta","orcid":"https://orcid.org/0000-0003-3602-1981","observed_orcids":["https://orcid.org/0000-0003-3602-1981"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Gupta","raw_affiliation_strings":["National Institutes of Health, 30 Convent Drive, Building 30, Room 228, MSC 4320, Bethesda, Maryland 20892-4320, USA","Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research (A.G., M.T.C.), Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, 30 Convent Drive, Building 30, Room 228, MSC 4320, Bethesda, Maryland 20892-4320, USA","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research (A.G., M.T.C.), Bethesda, Maryland","institution_ids":["https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088295689","display_name":"Karen K. Winer","orcid":"https://orcid.org/0000-0001-8261-5188","observed_orcids":["https://orcid.org/0000-0001-8261-5188"]},"institutions":[{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Winer","raw_affiliation_strings":["National Institute of Child Health and Human Development (K.W.), Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Child Health and Human Development (K.W.), Bethesda, Maryland","institution_ids":["https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011066885","display_name":"Michael J. Econs","orcid":"https://orcid.org/0000-0003-0940-1911","observed_orcids":["https://orcid.org/0000-0003-0940-1911"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. J. Econs","raw_affiliation_strings":["Division of Endocrinology and Metabolism (M.J.E.) Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism (M.J.E.) Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103038670","display_name":"Stephen J. Marx","orcid":"https://orcid.org/0000-0001-9317-332X","observed_orcids":["https://orcid.org/0000-0001-9317-332X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. J. Marx","raw_affiliation_strings":["Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases (S.J.M.), National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases (S.J.M.), National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084587886","display_name":"Michael Terrence Collins","orcid":"https://orcid.org/0000-0003-3676-7644","observed_orcids":["https://orcid.org/0000-0003-3676-7644"]},"institutions":[{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. T. Collins","raw_affiliation_strings":["Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research (A.G., M.T.C.), Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research (A.G., M.T.C.), Bethesda, Maryland","institution_ids":["https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5084587886"],"corresponding_institution_ids":["https://openalex.org/I4210088259"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":7.5566,"has_fulltext":false,"cited_by_count":167,"citation_normalized_percentile":{"value":0.97419868,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"89","issue":"9","first_page":"4489","last_page":"4492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chronic-hypoparathyroidism","display_name":"chronic hypoparathyroidism","score":0.9110000133514404},{"id":"https://openalex.org/keywords/primary-hyperparathyroidism","display_name":"primary hyperparathyroidism","score":0.8930000066757202},{"id":"https://openalex.org/keywords/phosphorus-metabolism","display_name":"phosphorus metabolism","score":0.781000018119812},{"id":"https://openalex.org/keywords/renal-phosphate-excretion","display_name":"renal phosphate excretion","score":0.6579999923706055},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8009999990463257},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-induced-osteomalacia","display_name":"tumor-induced osteomalacia","score":0.7829999923706055},{"id":"https://openalex.org/keywords/x-linked-hypophosphatemia","display_name":"X-linked hypophosphatemia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/fibrous-dysplasia","display_name":"fibrous dysplasia","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2776036575","wikidata":"https://www.wikidata.org/wiki/Q1641062","display_name":"Hyperphosphatemia","level":3,"score":0.9462568163871765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8544440269470215},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8042871952056885},{"id":"https://openalex.org/C2778573388","wikidata":"https://www.wikidata.org/wiki/Q1641384","display_name":"Hypophosphatemia","level":2,"score":0.783765971660614},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.7481698989868164},{"id":"https://openalex.org/C2775941721","wikidata":"https://www.wikidata.org/wiki/Q1586088","display_name":"Hypoparathyroidism","level":2,"score":0.6975076794624329},{"id":"https://openalex.org/C2775945674","wikidata":"https://www.wikidata.org/wiki/Q1344835","display_name":"Hyperparathyroidism","level":2,"score":0.5766928195953369},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.5679951310157776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5607671141624451},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.44464319944381714},{"id":"https://openalex.org/C2778838027","wikidata":"https://www.wikidata.org/wiki/Q3622611","display_name":"Secondary hyperparathyroidism","level":4,"score":0.42173928022384644},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4002096652984619},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3929470181465149}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007011","descriptor_name":"Hypoparathyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2004-0724","doi":"https://doi.org/10.1210/jc.2004-0724","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2004-0724","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:15356053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15356053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2421666625","https://openalex.org/W4417529537","https://openalex.org/W2079644585","https://openalex.org/W2100203105","https://openalex.org/W2101581654","https://openalex.org/W2017219647","https://openalex.org/W4390919618","https://openalex.org/W7096531439","https://openalex.org/W2400188057","https://openalex.org/W7097720586"],"abstract_inverted_index":{"The":[0,68],"Identification":[1],"and":[2,24,54,83,93,104,110,118,144,152,180,235,250],"characterization":[3],"of":[4,22,31,36,70,101,164,203,257,262,264],"FGF-23":[5,18,25,37,72,109,204,227,245,265],"has":[6],"provided":[7],"an":[8,127],"opportunity":[9],"to":[10,247,268],"gain":[11],"new":[12],"insight":[13],"into":[14],"phosphorus":[15,166,249],"metabolism.":[16],"Circulating":[17],"promotes":[19],"renal":[20,43],"excretion":[21],"phosphorus,":[23],"is":[26,73,266],"measurable":[27],"in":[28,40,113,123,231,242,254],"the":[29,58,76,98,124,255,260],"serum":[30,63,71,80,92,102,108,165,226,244,248,270],"normal":[32,155,172],"subjects.":[33],"Serum":[34,120],"levels":[35,112,163,202,228],"are":[38,65,229],"elevated":[39,230],"patients":[41,114,135,148,168,232],"with":[42,115,136,142,149,158,169,233],"phosphate":[44,111],"wasting":[45],"disorders":[46],"such":[47],"as":[48],"tumor":[49],"induced":[50],"osteomalacia,":[51],"X-linked":[52],"hypophosphatemia":[53],"fibrous":[55],"dysplasia.":[56],"However,":[57,253],"factors":[59],"that":[60,78],"alter":[61],"its":[62],"concentration":[64],"not":[66],"known.":[67],"study":[69],"confounded":[74],"by":[75],"fact":[77],"high":[79],"calcium,":[81,105],"PTH,":[82],"any":[84],"other":[85],"putative":[86],"phosphotonins,":[87],"have":[88],"similar":[89],"effects":[90],"on":[91,139],"urine":[94],"phosphorus.":[95,271],"To":[96],"circumvent":[97],"confounding":[99],"effect":[100],"PTH":[103],"we":[106],"studied":[107],"chronic":[116,137,236,258],"hypoparathyroidism":[117,138,159],"hyperphosphatemia.":[119],"was":[121],"collected":[122],"morning":[125],"after":[126],"overnight":[128],"fast":[129],"from":[130],"three":[131],"groups:":[132],"1)":[133],"9":[134,147],"stable":[140],"treatment":[141],"calcium":[143],"calcitriol,":[145],"2)":[146],"primary":[150],"hyperparathyroidism,":[151],"3)":[153],"77":[154],"controls.":[156],"Patients":[157],"had":[160,200],"predictably":[161],"higher":[162,201],"than":[167],"hyperparathyroidism":[170],"or":[171,212],"controls":[173],"(5.6":[174],"+/-":[175,178,182,186,206,210,214],"1.1,":[176],"3.1":[177,181],"0.6,":[179],"0.5":[183],"mg/dL,":[184],"mean":[185],"1":[187],"SD,":[188],"respectively":[189,217],"(p":[190,218],"<":[191,219],"0.01":[192],"for":[193],"hypoparathyroid":[194],"vs.":[195,208,221],"either":[196,222],"group)).":[197,223],"They":[198],"also":[199],"(150":[205],"120":[207],"70":[209],"60,":[211],"55":[213],"20":[215],"RIU/ml,":[216],"0.05":[220],"In":[224],"conclusion,":[225],"hyperphosphatemia":[234],"hypoparathyroidism,":[237,259],"suggesting":[238],"a":[239],"feedback":[240],"system":[241],"which":[243],"responds":[246],"regulates":[251],"it.":[252],"setting":[256],"degree":[261],"elevation":[263],"insufficient":[267],"normalize":[269]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}