{"id":"https://openalex.org/W2083201643","doi":"https://doi.org/10.1115/sbc2009-204389","title":"Structural Deformation of Native Aortic Valve Leaflet Under Hypertension: An In Vitro Study","display_name":"Structural Deformation of Native Aortic Valve Leaflet Under Hypertension: An In Vitro Study","publication_year":2009,"publication_date":"2009-06-17","ids":{"openalex":"https://openalex.org/W2083201643","doi":"https://doi.org/10.1115/sbc2009-204389","mag":"2083201643"},"language":"en","primary_location":{"id":"doi:10.1115/sbc2009-204389","doi":"https://doi.org/10.1115/sbc2009-204389","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2009-204389","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2009 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061269469","display_name":"Choon Hwai Yap","orcid":"https://orcid.org/0000-0003-2918-3077","observed_orcids":["https://orcid.org/0000-0003-2918-3077"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. H. Yap","raw_affiliation_strings":["Emory University, Atlanta, GA","Georgia Institute of Technology, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073941518","display_name":"H. S. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. S. Kim","raw_affiliation_strings":["Georgia Institute of Technology, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013397653","display_name":"Lakshmi Prasad Dasi","orcid":"https://orcid.org/0000-0003-3776-0073","observed_orcids":["https://orcid.org/0000-0003-3776-0073"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. P. Dasi","raw_affiliation_strings":["Emory University, Atlanta, GA","Georgia Institute of Technology, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091475209","display_name":"Michael J. Weiler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. J. Weiler","raw_affiliation_strings":["Emory University, Atlanta, GA","Georgia Institute of Technology, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048141314","display_name":"Kartik Balachandran","orcid":"https://orcid.org/0000-0002-8550-822X","observed_orcids":["https://orcid.org/0000-0002-8550-822X"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Balachandran","raw_affiliation_strings":["Emory University, Atlanta, GA","Georgia Institute of Technology, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050034908","display_name":"Rami M. Haj-Ali","orcid":"https://orcid.org/0000-0002-1761-7344","observed_orcids":["https://orcid.org/0000-0002-1761-7344"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"R. Haj-Ali","raw_affiliation_strings":["Georgia Institute of Technology, Atlanta, GA","Tel-Aviv University, Ramat Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Tel-Aviv University, Ramat Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087746871","display_name":"Ajit P. Yoganathan","orcid":"https://orcid.org/0000-0001-5818-1316","observed_orcids":["https://orcid.org/0000-0001-5818-1316"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. P. Yoganathan","raw_affiliation_strings":["Emory University, Atlanta, GA","Georgia Institute of Technology, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13838384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"925","last_page":"926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aortic-valve-leaflets","display_name":"aortic valve leaflets","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8519999980926514},{"id":"https://openalex.org/keywords/calcific-aortic-valve-disease","display_name":"calcific aortic valve disease","score":0.9070000052452087},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.753000020980835},{"id":"https://openalex.org/keywords/membrane-tension","display_name":"membrane tension","score":0.6650000214576721},{"id":"https://openalex.org/keywords/leaflet-deformation","display_name":"leaflet deformation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/valve-biomechanics","display_name":"valve biomechanics","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C123576724","wikidata":"https://www.wikidata.org/wiki/Q1299082","display_name":"Afterload","level":3,"score":0.7441034317016602},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7204210758209229},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.6969121694564819},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6677109599113464},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.4960382878780365},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.47476887702941895},{"id":"https://openalex.org/C26635844","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricular pressure","level":3,"score":0.45185792446136475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.449362188577652},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3581046462059021},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3313090205192566},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07268646359443665}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/sbc2009-204389","doi":"https://doi.org/10.1115/sbc2009-204389","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2009-204389","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2009 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979258368","https://openalex.org/W4416193903","https://openalex.org/W2028258601","https://openalex.org/W2012073619","https://openalex.org/W2063182111","https://openalex.org/W2076762198","https://openalex.org/W2742786568","https://openalex.org/W7098539636","https://openalex.org/W2125261131","https://openalex.org/W2301955581"],"abstract_inverted_index":{"The":[0],"aortic":[1,35,93,110],"valve":[2,18,47,81,94,111,129],"(AV)":[3],"is":[4],"a":[5,11,117],"complex":[6,12],"structure":[7],"that":[8,62],"functions":[9],"in":[10,96],"dynamic":[13],"environment.":[14],"During":[15,40],"systole,":[16],"the":[17,22,38,46,53,76,80,97,120,124,128],"leaflets":[19,82],"bend":[20],"at":[21],"base":[23],"to":[24,50,91],"open":[25],"and":[26,34,71,83],"experience":[27],"fluid":[28,72],"shear":[29,73],"stress":[30,74],"on":[31,127],"both":[32],"ventricular":[33],"sides":[36],"of":[37,79,107,119],"leaflet.":[39],"diastole,":[41],"adverse":[42],"pressure":[43,122],"gradient":[44],"closes":[45],"causing":[48],"it":[49],"structurally":[51],"support":[52],"systemic":[54],"afterload":[55],"pressure.":[56],"Ex":[57],"vivo":[58],"experiments":[59],"has":[60],"shown":[61],"isolated":[63],"mechanical":[64],"forces":[65],"such":[66],"as":[67],"pressure,":[68],"membrane":[69],"tension,":[70],"affects":[75],"remodeling":[77],"activities":[78],"also":[84],"elicit":[85],"pathological":[86],"responses":[87],"[1],":[88],"potentially":[89],"leading":[90],"calcific":[92,109],"disease":[95,112],"long":[98],"term.":[99],"Clinically,":[100],"patients":[101],"with":[102],"hypertension":[103],"have":[104],"increased":[105,121,125],"risk":[106],"developing":[108],"[2],":[113],"which":[114],"could":[115],"be":[116],"result":[118],"or":[123],"stretch":[126],"leaflets.":[130]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}