{"id":"https://openalex.org/W2083201433","doi":"https://doi.org/10.1103/physrevlett.84.1343","title":"A Space-Time Adaptive Method for Simulating Complex Cardiac Dynamics","display_name":"A Space-Time Adaptive Method for Simulating Complex Cardiac Dynamics","publication_year":2000,"publication_date":"2000-02-07","ids":{"openalex":"https://openalex.org/W2083201433","doi":"https://doi.org/10.1103/physrevlett.84.1343","mag":"2083201433","pmid":"https://pubmed.ncbi.nlm.nih.gov/11017514"},"language":"en","primary_location":{"id":"doi:10.1103/physrevlett.84.1343","doi":"https://doi.org/10.1103/physrevlett.84.1343","is_oa":false,"landing_page_url":"https://doi.org/10.1103/physrevlett.84.1343","pdf_url":null,"source":{"id":"https://openalex.org/S24807848","display_name":"Physical Review Letters","issn_l":"0031-9007","issn":["0031-9007","1079-7114","1092-0145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Review Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/physics/9908008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053674481","display_name":"Elizabeth M. Cherry","orcid":"https://orcid.org/0000-0001-5194-9572","observed_orcids":["https://orcid.org/0000-0001-5194-9572"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Cherry","raw_affiliation_strings":["Department of Computer Science, Duke University, P.O. Box 90129, Durham, North Carolina 27708-0129, USA. emc@cs.duke.edu","Department of Computer Science, Duke University, P.O. Box 90129, Durham, North Carolina, 27708-0129#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Duke University, P.O. Box 90129, Durham, North Carolina 27708-0129, USA. emc@cs.duke.edu","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Computer Science, Duke University, P.O. Box 90129, Durham, North Carolina, 27708-0129#TAB#","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007126112","display_name":"Henry Greenside","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry S. Greenside","raw_affiliation_strings":["Department of Physics, Duke University, Durham, North Carolina 27708-0305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Duke University, Durham, North Carolina 27708-0305","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016723450","display_name":"Craig S. Henriquez","orcid":"https://orcid.org/0000-0002-5395-3767","observed_orcids":["https://orcid.org/0000-0002-5395-3767"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig S. Henriquez","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708-0281"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708-0281","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.7021,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.9338545,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"84","issue":"6","first_page":"1343","last_page":"1346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11416","display_name":"Numerical methods for differential equations","score":0.1177000030875206,"subfield":{"id":"https://openalex.org/subfields/2612","display_name":"Numerical Analysis"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.03370000049471855,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luo-rudy-model","display_name":"Luo-Rudy model","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.9430000185966492},{"id":"https://openalex.org/keywords/spiral-waves","display_name":"spiral waves","score":0.8569999933242798},{"id":"https://openalex.org/keywords/computational-efficiency","display_name":"computational efficiency","score":0.4970000088214874},{"id":"https://openalex.org/keywords/human-heart","display_name":"human heart","score":0.7099999785423279},{"id":"https://openalex.org/keywords/time-integration-methods","display_name":"time integration methods","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.7031377553939819},{"id":"https://openalex.org/C174128100","wikidata":"https://www.wikidata.org/wiki/Q846907","display_name":"Spiral (railway)","level":2,"score":0.6028954982757568},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5522873997688293},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.5400257110595703},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5366425514221191},{"id":"https://openalex.org/C17825722","wikidata":"https://www.wikidata.org/wiki/Q17285","display_name":"Plane (geometry)","level":2,"score":0.5163365602493286},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.49064770340919495},{"id":"https://openalex.org/C130187892","wikidata":"https://www.wikidata.org/wiki/Q133327","display_name":"Spacetime","level":2,"score":0.4861178398132324},{"id":"https://openalex.org/C96402334","wikidata":"https://www.wikidata.org/wiki/Q3030793","display_name":"Space time","level":2,"score":0.47882869839668274},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.46016380190849304},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4377307891845703},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3566783666610718},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.17934098839759827},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16147011518478394},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14762908220291138},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.12975481152534485},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.10299262404441833},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1103/physrevlett.84.1343","doi":"https://doi.org/10.1103/physrevlett.84.1343","is_oa":false,"landing_page_url":"https://doi.org/10.1103/physrevlett.84.1343","pdf_url":null,"source":{"id":"https://openalex.org/S24807848","display_name":"Physical Review Letters","issn_l":"0031-9007","issn":["0031-9007","1079-7114","1092-0145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Review Letters","raw_type":"journal-article"},{"id":"pmid:11017514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11017514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical review letters","raw_type":"Comparative Study"},{"id":"pmh:oai:arXiv.org:physics/9908008","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/physics/9908008","pdf_url":"https://arxiv.org/pdf/physics/9908008","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:cds.cern.ch:395747","doi":null,"is_oa":false,"landing_page_url":"http://cds.cern.ch/record/395747","pdf_url":null,"source":{"id":"https://openalex.org/S4306402195","display_name":"CERN Document Server (European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"doi:10.48550/arxiv.physics/9908008","doi":"https://doi.org/10.48550/arxiv.physics/9908008","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.physics/9908008","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:2982838783","doi":null,"is_oa":false,"landing_page_url":"http://ui.adsabs.harvard.edu/abs/2000APS..MARS36167C/abstract","pdf_url":null,"source":{"id":"https://openalex.org/S4306502653","display_name":"APS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"APS","raw_type":null}],"best_oa_location":{"id":"pmh:oai:arXiv.org:physics/9908008","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/physics/9908008","pdf_url":"https://arxiv.org/pdf/physics/9908008","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1965550877","https://openalex.org/W1983043808","https://openalex.org/W1986023817","https://openalex.org/W2004875888","https://openalex.org/W2021921746","https://openalex.org/W2025168041","https://openalex.org/W2027832518","https://openalex.org/W2028146834","https://openalex.org/W2029983732","https://openalex.org/W2049789477","https://openalex.org/W2052620890","https://openalex.org/W2061488653","https://openalex.org/W2077047259","https://openalex.org/W2107194310","https://openalex.org/W2146077760","https://openalex.org/W4292169137"],"related_works":["https://openalex.org/W2107194310","https://openalex.org/W2280946954","https://openalex.org/W149709301","https://openalex.org/W423463640","https://openalex.org/W2152787675","https://openalex.org/W2153304938","https://openalex.org/W2065137356","https://openalex.org/W2168100100","https://openalex.org/W2283649028","https://openalex.org/W1143495282"],"abstract_inverted_index":{"For":[0],"plane-wave":[1],"and":[2,38],"many-spiral":[3],"states":[4],"of":[5,12,32],"the":[6,55,76],"experimentally":[7],"based":[8],"Luo-Rudy":[9],"1":[10],"model":[11],"heart":[13],"tissue":[14],"in":[15,35,43],"large":[16],"(8":[17],"cm":[18],"square)":[19],"domains,":[20],"we":[21],"show":[22],"that":[23,61],"a":[24,30,41,50],"space-time-adaptive":[25],"time-integration":[26],"algorithm":[27,48,64],"can":[28,65],"achieve":[29],"factor":[31],"5":[33],"reduction":[34,42],"computational":[36],"effort":[37],"memory-but":[39],"without":[40],"accuracy-when":[44],"compared":[45],"to":[46,69],"an":[47,63],"using":[49],"uniform":[51],"space-time":[52],"mesh":[53],"at":[54],"finest":[56],"resolution.":[57],"Our":[58],"results":[59],"indicate":[60],"such":[62],"be":[66],"extended":[67],"straightforwardly":[68],"simulate":[70],"quantitatively":[71],"three-dimensional":[72],"electrical":[73],"dynamics":[74],"over":[75],"whole":[77],"human":[78],"heart.":[79]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}