{"id":"https://openalex.org/W2083198620","doi":"https://doi.org/10.1212/wnl.78.1_meetingabstracts.s45.006","title":"Preliminary Data from a Multicenter, Phase II, Randomized, Non-Comparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly-Diagnosed Glioblastoma (GBM) (S45.006)","display_name":"Preliminary Data from a Multicenter, Phase II, Randomized, Non-Comparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly-Diagnosed Glioblastoma (GBM) (S45.006)","publication_year":2012,"publication_date":"2012-04-22","ids":{"openalex":"https://openalex.org/W2083198620","doi":"https://doi.org/10.1212/wnl.78.1_meetingabstracts.s45.006","mag":"2083198620"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.78.1_meetingabstracts.s45.006","doi":"https://doi.org/10.1212/wnl.78.1_meetingabstracts.s45.006","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.78.1_meetingabstracts.s45.006","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035087247","display_name":"Eudocia Q. Lee","orcid":"https://orcid.org/0000-0003-3355-5179","observed_orcids":["https://orcid.org/0000-0003-3355-5179"]},"institutions":[{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Lee","raw_affiliation_strings":["1 Dana Farber/Brigham and Women's Cancer Center Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Dana Farber/Brigham and Women's Cancer Center Boston","institution_ids":["https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069527451","display_name":"Tracy T. Batchelor","orcid":"https://orcid.org/0000-0001-7568-6607","observed_orcids":["https://orcid.org/0000-0001-7568-6607"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Batchelor","raw_affiliation_strings":["(2)Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(2)Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042155392","display_name":"Thomas Joseph Kaley","orcid":"https://orcid.org/0000-0002-2540-8518","observed_orcids":["https://orcid.org/0000-0002-2540-8518"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Kaley","raw_affiliation_strings":["3 Memorial Sloan Kettering Cancer Center ,  New York, NY ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Memorial Sloan Kettering Cancer Center ,  New York, NY ,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027429195","display_name":"D. Schiff","orcid":"https://orcid.org/0000-0002-1896-2502","observed_orcids":["https://orcid.org/0000-0002-1896-2502"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Schiff","raw_affiliation_strings":["4 University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4 University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057541817","display_name":"Andrew B. Lassman","orcid":"https://orcid.org/0000-0001-7386-9928","observed_orcids":["https://orcid.org/0000-0001-7386-9928"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Lassman","raw_affiliation_strings":["5 Memorial Sloan Kettering Cancer Center ,  New York, NY ,  "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 Memorial Sloan Kettering Cancer Center ,  New York, NY ,  ","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047993679","display_name":"Eric T. Wong","orcid":"https://orcid.org/0000-0001-7112-6207","observed_orcids":["https://orcid.org/0000-0001-7112-6207"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Wong","raw_affiliation_strings":["6 Beth Israel Deaconess Medical Center Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6 Beth Israel Deaconess Medical Center Boston","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069699492","display_name":"Tom Mikkelsen","orcid":"https://orcid.org/0000-0001-6285-2442","observed_orcids":["https://orcid.org/0000-0001-6285-2442"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Mikkelsen","raw_affiliation_strings":["7 Henry Ford Hospital Detroit MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7 Henry Ford Hospital Detroit MI","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076042525","display_name":"Benjamin W. Purow","orcid":"https://orcid.org/0000-0001-7372-6062","observed_orcids":["https://orcid.org/0000-0001-7372-6062"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Purow","raw_affiliation_strings":["8 University of Virginia Charlottesville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8 University of Virginia Charlottesville","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030800663","display_name":"J. Drappatz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Drappatz","raw_affiliation_strings":["#N##TAB##TAB##TAB##TAB#9 University of Pittsburgh, Pittsburgh, PA;#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB#9 University of Pittsburgh, Pittsburgh, PA;#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029013340","display_name":"Andrew David Norden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Norden","raw_affiliation_strings":["10 Dana Farber/Brigham and Women's Cancer Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10 Dana Farber/Brigham and Women's Cancer Center Boston MA","institution_ids":["https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041980697","display_name":"Rameen Beroukhim","orcid":"https://orcid.org/0000-0001-6303-3609","observed_orcids":["https://orcid.org/0000-0001-6303-3609","https://orcid.org/0000-0002-5506-0575"]},"institutions":[{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Beroukhim","raw_affiliation_strings":["11 Dana Farber/Brigham and Women's Cancer Center Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11 Dana Farber/Brigham and Women's Cancer Center Boston","institution_ids":["https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103821890","display_name":"Simone Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Weiss","raw_affiliation_strings":["12Radiation Oncology Brigham and Women's Hospital Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Radiation Oncology Brigham and Women's Hospital Boston","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047888321","display_name":"Brian Michael Alexander","orcid":"https://orcid.org/0000-0003-3903-9175","observed_orcids":["https://orcid.org/0000-0003-3903-9175"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Alexander","raw_affiliation_strings":["13 Brigham and Women's Hospital Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13 Brigham and Women's Hospital Boston MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111785291","display_name":"Christine Sceppa McCluskey","orcid":"https://orcid.org/0000-0001-5610-8115","observed_orcids":["https://orcid.org/0000-0001-5610-8115"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. McCluskey","raw_affiliation_strings":["14 Dana Farber Cancer Institute Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14 Dana Farber Cancer Institute Boston","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112095475","display_name":"Mary Gerard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Gerard","raw_affiliation_strings":["15 Dana Farber Cancer Institute Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15 Dana Farber Cancer Institute Boston","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035377136","display_name":"Lynsey Teulings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Teulings","raw_affiliation_strings":["16 Dana Farber Cancer Institute Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16 Dana Farber Cancer Institute Boston","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087377374","display_name":"Kerrington D. Smith","orcid":"https://orcid.org/0000-0001-7225-2029","observed_orcids":["https://orcid.org/0000-0001-7225-2029"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Smith","raw_affiliation_strings":["17 Dana Farber Cancer Institute Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17 Dana Farber Cancer Institute Boston","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013091949","display_name":"Alona Muzikansky","orcid":"https://orcid.org/0000-0001-7585-8181","observed_orcids":["https://orcid.org/0000-0001-7585-8181"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Muzikansky","raw_affiliation_strings":["18 Massachusetts General Hospital Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18 Massachusetts General Hospital Boston MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021656597","display_name":"Patrick Yung Wen","orcid":"https://orcid.org/0000-0002-0774-7700","observed_orcids":["https://orcid.org/0000-0002-0774-7700","https://orcid.org/0000-0003-3224-3042","https://orcid.org/0000-0002-2452-0540"]},"institutions":[{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Wen","raw_affiliation_strings":["19 Dana Farber/Brigham and Women's Cancer Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"19 Dana Farber/Brigham and Women's Cancer Center Boston MA","institution_ids":["https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"Meeting Abstracts 1","first_page":"S45.006","last_page":"S45.006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/vandetanib","display_name":"vandetanib","score":0.9570000171661377},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vegfr-2-inhibition","display_name":"VEGFR-2 inhibition","score":0.8410000205039978},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibition","display_name":"EGFR tyrosine kinase inhibition","score":0.7979999780654907},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.640999972820282},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9359999895095825},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6359999775886536},{"id":"https://openalex.org/keywords/newly-diagnosed-glioblastoma","display_name":"newly diagnosed glioblastoma","score":0.734000027179718},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3930000066757202},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/elevated-liver-enzymes","display_name":"elevated liver enzymes","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2780333294","wikidata":"https://www.wikidata.org/wiki/Q7914515","display_name":"Vandetanib","level":4,"score":0.9068616628646851},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8916171789169312},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.7923729419708252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6650649905204773},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.534466564655304},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5117849707603455},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4876040518283844},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.4518347680568695},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.416521281003952},{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.412153959274292},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3592280447483063},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3453913629055023},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.29998964071273804},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22011038661003113},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.15631961822509766},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.78.1_meetingabstracts.s45.006","doi":"https://doi.org/10.1212/wnl.78.1_meetingabstracts.s45.006","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.78.1_meetingabstracts.s45.006","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2591046012","https://openalex.org/W2032690575","https://openalex.org/W2247287286","https://openalex.org/W2037113925","https://openalex.org/W2024831249","https://openalex.org/W2242914525","https://openalex.org/W2078146190","https://openalex.org/W2109583483","https://openalex.org/W4232376350","https://openalex.org/W377634215"],"abstract_inverted_index":{"Objective:":[0],"We":[2,65,171],"conducted":[3],"a":[4,69,77,487,530,585],"randomized":[5],"phase":[6],"II":[7],"study":[8,281],"of":[9,40,54,71,79,124,156,293],"vandetanib":[10,88,204,294],"in":[11,16,35,76,176,180,202,227,238,251,262,298,350,383,539,544,560,659],"patients":[12,75],"with":[13,18,130,183,222,233,246,257,336,365,417,437,497,527,584,643],"newly-diagnosed":[14,73,299],"GBM":[15,74,300],"combination":[17],"radiation":[19,48],"(RT)":[20],"and":[21,29,38,56,100,140,165,190,213,230,254,279,314,338,375,401,419,456,469,484,499,565,647,688],"temozolomide":[22],"(TMZ).":[23],"Background":[26],"EGFR":[28,57],"VEGFR":[30],"signaling":[31],"have":[32],"been":[33],"implicated":[34],"the":[36,154,203,280,291,308],"development":[37],"growth":[39],"GBM.":[41],"In":[42],"addition,":[43],"angiogenesis":[44],"inhibitors":[45],"may":[46,301],"enhance":[47],"sensitivity.":[49],"Vandetanib":[50],"is":[51,219,243],"an":[52,267,341,351,384,551,660],"inhibitor":[53],"VEGFR-2":[55],"tyrosine":[58],"kinase":[59],"activities.":[60],"Design/Methods:":[63],"planned":[66],"to":[67,81,114,266,295,307,407,505,511,517,603,609,615,621,627,633],"randomize":[68],"total":[70],"114":[72],"ratio":[78],"1:2":[80],"Arm":[82,86,177,181,228,239,252,263],"A:":[83],"RT/TMZ":[84],"or":[85],"B:":[87],"100":[89],"mg":[90],"daily":[91],"+":[92],"RT/TMZ.":[93],"All":[94],"pts":[95,174],"received":[96,331,347,360,380,393,412,424,432,462,476,492,522,571,579,594,638,656,668],"RT":[97,589],"(60":[98],"Gy)":[99],"concurrent":[101],"TMZ":[102,111],"75":[103],"mg/m":[104,118],"2":[105,119],"daily,":[107],"followed":[108],"by":[109],"adjuvant":[110],"for":[112,334,354,363,387,415,435,495,525,582,641,663],"up":[113],"12":[115],"cycles":[116],"(150-200":[117],"on":[121,142],"days":[122,221,232,245,256],"1-5":[123],"each":[125],"28":[126],"day":[127],"cycle).":[128],"Pts":[129],"age":[131,185],"\u2265":[132,138,199],"18,":[133],"Karnofsky":[134],"performance":[135],"status":[136],"(KPS)":[137],"60,":[139],"not":[141,302],"enzyme-inducing":[143],"antiepileptics":[144],"were":[145,206],"eligible.":[146],"Primary":[147],"endpoint":[148],"was":[149,276,282,548],"overall":[150],"survival":[151,163,273],"(OS)":[152],"from":[153,396,427,465,479,574,597,671],"date":[155],"randomization.":[157],"Secondary":[158],"endpoints":[159],"included":[160],"median":[161,184,191,217],"progression-free":[162],"(PFS)":[164],"safety.":[166],"Results:":[169],"enrolled":[172],"106":[173],"(36":[175],"A,":[178],"70":[179],"B)":[182],"59":[186],"yrs":[187],"(range:":[188,194],"23-83)":[189],"KPS":[192],"90":[193],"60-100).":[195],"Most":[196],"frequent":[197],"Gr":[198],"3":[200],"AEs":[201],"arm":[205],"lymphopenia":[207],"(20%),":[208],"thrombosis":[209],"(12.5%),":[210],"transaminitis":[211],"(8%)":[212],"leukopenia":[214],"(5%).":[215],"Preliminary":[216],"OS":[218,305],"487":[220],"95%":[223,234,247,258],"CI":[224,235,248,259],"(350,":[225],"NR)":[226],"A":[229,253],"503":[231],"(451,":[236],"634)":[237],"B.":[240,264],"Median":[241],"PFS":[242],"141":[244],"(104.":[249],"252)":[250],"127":[255],"(93.":[260],"165)":[261],"Due":[265],"unplanned":[268],"interim":[269],"analysis":[270],"demonstrating":[271],"no":[272],"difference,":[274],"enrollment":[275],"terminated":[277],"early":[278],"closed.":[283],"Conclusions:":[286],"Although":[288],"reasonably":[289],"well-tolerated,":[290],"addition":[292],"standard":[296],"chemoradiation":[297],"significantly":[303],"prolong":[304],"compared":[306],"parallel":[309],"control":[310],"arm.":[311],"Updated":[312],"efficacy":[313],"toxicity":[315],"data":[316],"will":[317],"be":[318],"presented.":[319],"Supported":[321],"by:":[322],"AstraZeneca.":[323],"Disclosure:":[326],"Dr.":[328,357,377,390,403,409,421,429,473,489,501,507,513,519,532,546,553,568,576,591,599,605,611,617,623,629,635,653,665],"Lee":[329,345],"has":[330,346,359,379,392,405,411,423,431,461,475,491,503,509,515,521,570,578,593,601,607,613,619,625,631,637,655,667],"personal":[332,348,361,381,413,433,493,523,580,639,657],"compensation":[333,349,362,382,414,434,494,524,581,640,658],"activities":[335,364,416,436,496,526,583,642],"Norvartis":[337],"Genentech":[339],"as":[340,486,529,550,588,649],"advisory":[342],"board":[343],"member.Dr.":[344],"editorial":[352,385,661],"capacity":[353,386,662],"UpToDate,":[355],"Inc.":[356,389],"Batchelor":[358,378,391],"Roche":[366],"Diagnostics":[367],"Corporation,":[368],"Genentech,":[369,442,468,679],"Inc.,":[370,374,443,445,447,680],"Merck":[371,498,644,682],"&":[372,645,683],"Co.":[373],"Millennium.":[376,402],"UpToDate":[388],"research":[394,425,463,477,543,572,595,669],"support":[395,426,464,478,573,596,670],"Pfizer":[397],"Inc,":[398,673,677],"AstraZeneca":[399,480,674],"Pharmaceuticals":[400,687],"Kaley":[404],"nothing":[406,504,510,516,602,608,614,620,626,632],"disclose.":[408,506,512,518,604,610,616,622,628,634],"Schiff":[410,422],"Novocure":[418],"Genentech.":[420],"Exelixis.":[428],"Lassman":[430,460],"Schering-Plough":[438],"Corp.,":[439],"ImClone":[440],"Systems,":[441],"Eisai":[444,676],"Cephalon,":[446],"Physicians":[448],"Education":[449],"Resource,":[450],"The":[451],"Robert":[452],"Michael":[453],"Educational":[454],"Institute,":[455],"Medical":[457],"Communications":[458],"Media.Dr.":[459],"Keryx":[466],"Biopharmaceuticals,":[467],"Schering":[470],"Plough":[471],"Corp.":[472],"Wong":[474],"Pharmaceuticals,":[481,675],"Exelixis,":[482,678],"Novartis":[483,528,648],"NovoCure":[485],"researcher.":[488],"Mikkelsen":[490],"Roche.":[500],"Purow":[502],"Drappatz":[508],"Norden":[514],"Beroukhim":[520,533,547,554,569],"consultant.":[531],"holds":[534,555],"stock":[535,537,556,558],"and/or":[536,557,651],"options":[538,559],"AstraZeneca,":[540],"which":[541,545],"sponsored":[542],"involved":[549],"investigator.":[552],"Baxter,":[561],"CareFusion,":[562],"Edwards":[563],"Lifesciences,":[564],"Cardinal":[566],"Health.":[567],"Novartis.":[575],"Weiss":[577,592],"consulting":[586],"firm":[587],"expert.":[590],"Aposence.":[598],"Alexander":[600],"McCluskey":[606],"Gerard":[612],"Teulings":[618],"Smith":[624],"Muzikansky":[630],"Wen":[636,654,666],"Co.,":[646,684],"consutant":[650],"speaker.":[652],"UptoDate.":[664],"Amgen":[672],"Medimmune,":[681],"Novartis,":[685],"Sanofi-Aventis":[686],"Vascular":[689],"Biogenics.":[690]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}