{"id":"https://openalex.org/W2083175091","doi":"https://doi.org/10.1016/s0304-4165(01)00221-5","title":"Pyridoxal 5\u2032-phosphate inhibits DNA binding of HNF1","display_name":"Pyridoxal 5\u2032-phosphate inhibits DNA binding of HNF1","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2083175091","doi":"https://doi.org/10.1016/s0304-4165(01)00221-5","mag":"2083175091","pmid":"https://pubmed.ncbi.nlm.nih.gov/11786225"},"language":"en","primary_location":{"id":"doi:10.1016/s0304-4165(01)00221-5","doi":"https://doi.org/10.1016/s0304-4165(01)00221-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-4165(01)00221-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210238601","display_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","issn_l":"0304-4165","issn":["0304-4165","1872-8006"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072304907","display_name":"Tatsuzo Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"T Oka","raw_affiliation_strings":["Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, Japan. oka@vet.agri.kagoshima-u.ac.jp","Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University 1-21-24 Korimoto, Kagoshima 890-0065, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, Japan. oka@vet.agri.kagoshima-u.ac.jp","institution_ids":["https://openalex.org/I107139324"]},{"raw_affiliation_string":"Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University 1-21-24 Korimoto, Kagoshima 890-0065, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041165334","display_name":"Hitomi Sugitatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Sugitatsu","raw_affiliation_strings":["Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026194514","display_name":"H Nordin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Nordin","raw_affiliation_strings":["Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065242465","display_name":"Mahendra Kumar Thakur","orcid":"https://orcid.org/0000-0001-8274-3251","observed_orcids":["https://orcid.org/0000-0001-8274-3251"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M.K Thakur","raw_affiliation_strings":["Department of Zoology, Biochemistry and Molecular Biology Laboratory, Banaras Hindu University, Varanasi 221 005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Biochemistry and Molecular Biology Laboratory, Banaras Hindu University, Varanasi 221 005, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113561466","display_name":"Misako Aoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132400726","display_name":"University of Nagasaki","ror":"https://ror.org/03ppx1p25","country_code":"JP","type":"education","lineage":["https://openalex.org/I132400726"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Aoyama","raw_affiliation_strings":["Department of Nutrition, Faculty of Nursing and Nutrition, Siebold University of Nagasaki, Nagasaki 851-2195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Faculty of Nursing and Nutrition, Siebold University of Nagasaki, Nagasaki 851-2195, Japan","institution_ids":["https://openalex.org/I132400726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109970132","display_name":"Takayo Sasagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Sasagawa","raw_affiliation_strings":["Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan","institution_ids":["https://openalex.org/I193620225"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203042511","display_name":"Prefectural University of Kumamoto","ror":"https://ror.org/00b7yvh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I203042511"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I Suzuki","raw_affiliation_strings":["Department of Food and Nutrition, Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto 862-8502, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto 862-8502, Japan","institution_ids":["https://openalex.org/I203042511"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020475566","display_name":"Hideaki Tsuji","orcid":"https://orcid.org/0000-0002-2521-246X","observed_orcids":["https://orcid.org/0000-0002-2521-246X"]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Tsuji","raw_affiliation_strings":["Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan","institution_ids":["https://openalex.org/I193620225"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5072304907"],"corresponding_institution_ids":["https://openalex.org/I107139324"],"apc_list":{"value":3310,"currency":"USD","value_usd":3310},"apc_paid":null,"fwci":0.1925,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.41103377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"1568","issue":"3","first_page":"189","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.46560001373291016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.46560001373291016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.1492999941110611,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.08079999685287476,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyridoxal-5-phosphate","display_name":"pyridoxal phosphate","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hnf1","display_name":"HNF1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dna-binding-inhibition","display_name":"DNA binding inhibition","score":0.8190000057220459},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tissue-specific-transcription-factors","display_name":"tissue-specific transcription factors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/amino-terminal-extension","display_name":"amino-terminal extension","score":0.6349999904632568},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dna-binding-sites","display_name":"DNA binding sites","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.703593373298645},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6753889918327332},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6748796701431274},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6456884741783142},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.6059921383857727},{"id":"https://openalex.org/C2780859938","wikidata":"https://www.wikidata.org/wiki/Q3065731","display_name":"Pyridoxal","level":3,"score":0.6007750034332275},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5783025622367859},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5433240532875061},{"id":"https://openalex.org/C2776834122","wikidata":"https://www.wikidata.org/wiki/Q418957","display_name":"Pyridoxal phosphate","level":4,"score":0.5116174817085266},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.47537532448768616},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.46703052520751953},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.4121086597442627},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4059555232524872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33507436513900757},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2549949586391449},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2157454788684845},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21555373072624207},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.0930929183959961},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.0884295403957367}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007544","descriptor_name":"Isopropyl Thiogalactoside","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011732","descriptor_name":"Pyridoxal Phosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011732","descriptor_name":"Pyridoxal Phosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051537","descriptor_name":"Hepatocyte Nuclear Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051539","descriptor_name":"Hepatocyte Nuclear Factor 1-beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0304-4165(01)00221-5","doi":"https://doi.org/10.1016/s0304-4165(01)00221-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-4165(01)00221-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210238601","display_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","issn_l":"0304-4165","issn":["0304-4165","1872-8006"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","raw_type":"journal-article"},{"id":"pmid:11786225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11786225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W7408833","https://openalex.org/W337785430","https://openalex.org/W577649374","https://openalex.org/W1519032693","https://openalex.org/W1540224528","https://openalex.org/W1548712478","https://openalex.org/W1598874243","https://openalex.org/W1604383624","https://openalex.org/W1675036791","https://openalex.org/W1878298478","https://openalex.org/W1969954079","https://openalex.org/W1978040063","https://openalex.org/W1978496766","https://openalex.org/W2006511249","https://openalex.org/W2021456660","https://openalex.org/W2039862565","https://openalex.org/W2047441216","https://openalex.org/W2047883961","https://openalex.org/W2048356148","https://openalex.org/W2055993012","https://openalex.org/W2062423659","https://openalex.org/W2065010138","https://openalex.org/W2065050987","https://openalex.org/W2066215499","https://openalex.org/W2100837269","https://openalex.org/W2317118960","https://openalex.org/W2489881699","https://openalex.org/W4252035015"],"related_works":["https://openalex.org/W1525651958","https://openalex.org/W2065050987","https://openalex.org/W2031697457","https://openalex.org/W1982813962","https://openalex.org/W7073739757","https://openalex.org/W2052004843","https://openalex.org/W1855880198","https://openalex.org/W7096293450","https://openalex.org/W2806601547","https://openalex.org/W1974217132"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
