{"id":"https://openalex.org/W2083172399","doi":"https://doi.org/10.1016/j.jalz.2014.04.462","title":"THE EVALUATION OF MTOR PATHWAY DYSREGULATION AS A NOVEL BLOOD\u2010BASED PHENOTYPIC RISK BIOMARKER FOR THE ASSESSMENT OF ALZHEIMER'S DISEASE AND DEMENTIA","display_name":"THE EVALUATION OF MTOR PATHWAY DYSREGULATION AS A NOVEL BLOOD\u2010BASED PHENOTYPIC RISK BIOMARKER FOR THE ASSESSMENT OF ALZHEIMER'S DISEASE AND DEMENTIA","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W2083172399","doi":"https://doi.org/10.1016/j.jalz.2014.04.462","mag":"2083172399"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2014.04.462","doi":"https://doi.org/10.1016/j.jalz.2014.04.462","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.04.462","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037109052","display_name":"Harald Juergen Hampel","orcid":"https://orcid.org/0000-0003-0894-8982","observed_orcids":["https://orcid.org/0000-0003-0894-8982"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Harald Juergen Hampel","raw_affiliation_strings":["University of Frankfurt Frankfurt/Main Germany","University of Frankfurt, Frankfurt/Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Frankfurt Frankfurt/Main Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"University of Frankfurt, Frankfurt/Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108138196","display_name":"Bruno Dubois","orcid":"https://orcid.org/0000-0002-4038-231X","observed_orcids":["https://orcid.org/0000-0002-4038-231X","https://orcid.org/0009-0005-3685-9399"]},"institutions":[{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Dubois","raw_affiliation_strings":["Pierre and Marie Curie University Paris France","Pierre-and-Marie-Curie University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pierre and Marie Curie University Paris France","institution_ids":["https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Pierre-and-Marie-Curie University, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003002074","display_name":"Ian Grant McKeith","orcid":"https://orcid.org/0000-0002-9250-0568","observed_orcids":["https://orcid.org/0000-0002-9250-0568"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian McKeith","raw_affiliation_strings":["University of Newcastle upon Tyne Tyne and Wear United Kingdom","University of Newcastle upon Tyne, Tyne and Wear, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Newcastle upon Tyne Tyne and Wear United Kingdom","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"University of Newcastle upon Tyne, Tyne and Wear, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014262891","display_name":"John Tiernan O'Brien","orcid":"https://orcid.org/0000-0002-0837-5080","observed_orcids":["https://orcid.org/0000-0002-0837-5080"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John O'Brien","raw_affiliation_strings":["University of Cambridge Cambridge United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Cambridge United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619838","display_name":"Oscar L. L\u00f3pez","orcid":"https://orcid.org/0000-0002-8546-8256","observed_orcids":["https://orcid.org/0000-0002-8546-8256"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar Lopez","raw_affiliation_strings":["University of Pittsburgh Pittsburgh Pennsylvania United States","University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh Pennsylvania United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049277633","display_name":"Oskar Hansson","orcid":"https://orcid.org/0000-0001-8467-7286","observed_orcids":["https://orcid.org/0000-0001-8467-7286"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Oskar Hansson","raw_affiliation_strings":["Lund University Malm\u00f6 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lund University Malm\u00f6 Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020439447","display_name":"Richard J. Pither","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Pither","raw_affiliation_strings":["Cytox Ltd. Oxford United Kingdom","Cytox Ltd., Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytox Ltd. Oxford United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Cytox Ltd., Oxford, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071341444","display_name":"Rik R. Vandenberghe","orcid":"https://orcid.org/0000-0001-6237-2502","observed_orcids":["https://orcid.org/0000-0001-6237-2502"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rik Vandenberghe","raw_affiliation_strings":["KU Leuven Leuven Belgium","KU Leuven, Leuven (Belgium)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"KU Leuven, Leuven (Belgium)","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069514442","display_name":"Simone Lista","orcid":"https://orcid.org/0000-0001-6804-7858","observed_orcids":["https://orcid.org/0000-0001-6804-7858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simone Lista","raw_affiliation_strings":["Pierre and Marie Curie University Frankfurt am Main Germany","Pierre and Marie Curie University, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pierre and Marie Curie University Frankfurt am Main Germany","institution_ids":[]},{"raw_affiliation_string":"Pierre and Marie Curie University, Frankfurt am Main, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5037109052"],"corresponding_institution_ids":["https://openalex.org/I114090438"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16749422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"4S_Part_5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7772920727729797},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7107284665107727},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6017423272132874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5829077363014221},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5370923280715942},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4778282642364502},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4717721939086914},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4349576532840729},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36582300066947937},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33390992879867554},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2878554165363312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1923656463623047},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15389469265937805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13311657309532166},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07305288314819336}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2014.04.462","doi":"https://doi.org/10.1016/j.jalz.2014.04.462","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.04.462","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409059799","https://openalex.org/W1972242255","https://openalex.org/W2966412519","https://openalex.org/W1006589974","https://openalex.org/W2890927416","https://openalex.org/W1993101344","https://openalex.org/W2775021631","https://openalex.org/W1481122508","https://openalex.org/W4390605164","https://openalex.org/W2208745537"],"abstract_inverted_index":{"There":[0],"are":[1,124,135],"currently":[2],"no":[3],"reliable":[4],"tests":[5],"to":[6,31,87,117,164],"detect":[7],"risk":[8,24,54],"of":[9,22,45,47,60,68,74,84,90,109,143,155],"cognitive":[10],"decline":[11],"and":[12,25,63,96,120,153,161,170],"Alzheimer's":[13,37,61,165],"Disease":[14,62],"early":[15,93],"in":[16,78,147],"the":[17,43,48,57,75,82,88,107,140],"disease":[18,26],"process.":[19],"The":[20,66],"lack":[21],"blood-based":[23],"biomarkers":[27],"has":[28,41],"hampered":[29],"efforts":[30],"develop":[32],"effective":[33],"disease-modifying":[34],"therapies":[35],"for":[36,56,92,151],"Disease.":[38],"Emerging":[39],"research":[40,131],"highlighted":[42],"importance":[44],"dysregulation":[46,73],"mTOR":[49,76,110,144],"signalling":[50],"pathway":[51,77,111,145],"as":[52],"a":[53,69],"factor":[55],"future":[58],"development":[59,154],"related":[64],"disorders":[65],"validation":[67],"phenotypic":[70],"test":[71],"detecting":[72],"clinical":[79,94,97,130],"studies":[80,134],"offers":[81],"prospect":[83],"new":[85,115],"approaches":[86,116],"identification":[89],"subjects":[91],"intervention":[95,119],"trial":[98],"stratification.":[99],"In":[100],"addition,":[101],"it":[102],"is":[103],"possible":[104],"that":[105],"understanding":[106,139],"consequences":[108],"dysfunction":[112,146],"may":[113],"open":[114],"therapeutic":[118],"drug":[121],"development.":[122],"We":[123],"reporting":[125],"progress":[126],"from":[127],"two":[128],"ongoing":[129],"studies.":[132],"These":[133],"aimed":[136],"at":[137],"further":[138],"potential":[141],"use":[142],"peripheral":[148],"blood":[149],"lymphocytes":[150],"progression":[152],"prodromal":[156],"Mild":[157],"Cognitive":[158],"Impairment":[159],"(MCI)":[160],"dementia":[162],"due":[163],"Disease,":[166],"Frontal":[167],"Temporal":[168],"Dementia":[169],"Lewy":[171],"Body":[172],"Dementia.":[173]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}