{"id":"https://openalex.org/W2083166228","doi":"https://doi.org/10.1007/bf00272186","title":"Reexamination of paternal age effect in Down's syndrome","display_name":"Reexamination of paternal age effect in Down's syndrome","publication_year":1978,"publication_date":"1978-01-01","ids":{"openalex":"https://openalex.org/W2083166228","doi":"https://doi.org/10.1007/bf00272186","mag":"2083166228","pmid":"https://pubmed.ncbi.nlm.nih.gov/147234"},"language":"en","primary_location":{"id":"doi:10.1007/bf00272186","doi":"https://doi.org/10.1007/bf00272186","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00272186","pdf_url":null,"source":{"id":"https://openalex.org/S199832308","display_name":"Human Genetics","issn_l":"0018-7348","issn":["0018-7348","0340-6717","1432-1203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021732262","display_name":"Ei Matsunaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113198587","display_name":"National Institute of Genetics","ror":"https://ror.org/02xg1m795","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113198587","https://openalex.org/I1319490839","https://openalex.org/I4210158934"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ei Matsunaga","raw_affiliation_strings":["Department of Human Genetics, National Institute of Genetics, 411, Mishima, Shizuoka-Ken, Japan","Department of Human Genetics, National Institute of Genetics, Mishima, Shizuoka-ken, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, National Institute of Genetics, 411, Mishima, Shizuoka-Ken, Japan","institution_ids":["https://openalex.org/I113198587"]},{"raw_affiliation_string":"Department of Human Genetics, National Institute of Genetics, Mishima, Shizuoka-ken, Japan","institution_ids":["https://openalex.org/I113198587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024581670","display_name":"Akira Tonomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Tonomura","raw_affiliation_strings":["Department of Cytogenetics, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytogenetics, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091552705","display_name":"Hidetsune Oishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113198587","display_name":"National Institute of Genetics","ror":"https://ror.org/02xg1m795","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113198587","https://openalex.org/I1319490839","https://openalex.org/I4210158934"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetsune Oishi","raw_affiliation_strings":["Department of Human Genetics, National Institute of Genetics, 411, Mishima, Shizuoka-Ken, Japan","Department of Human Genetics, National Institute of Genetics, Mishima, Shizuoka-ken, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, National Institute of Genetics, 411, Mishima, Shizuoka-Ken, Japan","institution_ids":["https://openalex.org/I113198587"]},{"raw_affiliation_string":"Department of Human Genetics, National Institute of Genetics, Mishima, Shizuoka-ken, Japan","institution_ids":["https://openalex.org/I113198587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100993098","display_name":"Yasumoto Kikuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113198587","display_name":"National Institute of Genetics","ror":"https://ror.org/02xg1m795","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113198587","https://openalex.org/I1319490839","https://openalex.org/I4210158934"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasumoto Kikuchi","raw_affiliation_strings":["Department of Human Genetics, National Institute of Genetics, 411, Mishima, Shizuoka-Ken, Japan","Department of Human Genetics, National Institute of Genetics, Mishima, Shizuoka-ken, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, National Institute of Genetics, 411, Mishima, Shizuoka-Ken, Japan","institution_ids":["https://openalex.org/I113198587"]},{"raw_affiliation_string":"Department of Human Genetics, National Institute of Genetics, Mishima, Shizuoka-ken, Japan","institution_ids":["https://openalex.org/I113198587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":20.5243,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.99382761,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"40","issue":"3","first_page":"259","last_page":"268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/paternal-age","display_name":"paternal age","score":0.9449999928474426},{"id":"https://openalex.org/keywords/advanced-paternal-age","display_name":"advanced paternal age","score":0.7260000109672546},{"id":"https://openalex.org/keywords/maternal-age","display_name":"maternal age","score":0.734000027179718},{"id":"https://openalex.org/keywords/age-related-risk","display_name":"age-related risk","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C3020279770","wikidata":"https://www.wikidata.org/wiki/Q7144548","display_name":"Paternal age","level":4,"score":0.6714149713516235},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5865841507911682},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.535896897315979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5206558108329773},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48936909437179565},{"id":"https://openalex.org/C2779954681","wikidata":"https://www.wikidata.org/wiki/Q47715","display_name":"Down syndrome","level":2,"score":0.4698787033557892},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.4436700940132141},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.23165956139564514},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.14865288138389587},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12545651197433472},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008423","descriptor_name":"Maternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010331","descriptor_name":"Paternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00272186","doi":"https://doi.org/10.1007/bf00272186","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00272186","pdf_url":null,"source":{"id":"https://openalex.org/S199832308","display_name":"Human Genetics","issn_l":"0018-7348","issn":["0018-7348","0340-6717","1432-1203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics","raw_type":"journal-article"},{"id":"pmid:147234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/147234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W161873664","https://openalex.org/W2014971437","https://openalex.org/W2040761820","https://openalex.org/W2041615891","https://openalex.org/W2112557769","https://openalex.org/W2431145512","https://openalex.org/W2474367538","https://openalex.org/W4241421937","https://openalex.org/W4254694901"],"related_works":["https://openalex.org/W2126585984","https://openalex.org/W2112557769","https://openalex.org/W2052582741","https://openalex.org/W1824634375","https://openalex.org/W2341155135","https://openalex.org/W2004348221","https://openalex.org/W1965442008","https://openalex.org/W1977421889","https://openalex.org/W1736586300","https://openalex.org/W1975480100"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}