{"id":"https://openalex.org/W2083046877","doi":"https://doi.org/10.1111/j.1432-1033.1983.tb07555.x","title":"Identification of a Macromolecular Inhibitol of Glucocorticoid\u2010Receptor Complex Activation in Rat Liver Cytosol","display_name":"Identification of a Macromolecular Inhibitol of Glucocorticoid\u2010Receptor Complex Activation in Rat Liver Cytosol","publication_year":1983,"publication_date":"1983-08-01","ids":{"openalex":"https://openalex.org/W2083046877","doi":"https://doi.org/10.1111/j.1432-1033.1983.tb07555.x","mag":"2083046877","pmid":"https://pubmed.ncbi.nlm.nih.gov/6873061"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-1033.1983.tb07555.x","doi":"https://doi.org/10.1111/j.1432-1033.1983.tb07555.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1983.tb07555.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087315577","display_name":"Carol A. Barnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. BARNETT","raw_affiliation_strings":["Department of Biology and Molecukdr Biology Institute, San Diego State University, San Diego, California, USA 92182\u20130057"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecukdr Biology Institute, San Diego State University, San Diego, California, USA 92182\u20130057","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058408513","display_name":"Lynn SPECK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn SPECK","raw_affiliation_strings":["Department of Biology and Molecukdr Biology Institute, San Diego State University, San Diego, California, USA 92182\u20130057"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecukdr Biology Institute, San Diego State University, San Diego, California, USA 92182\u20130057","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062814155","display_name":"Gerald Litwack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald LITWACK","raw_affiliation_strings":["Department of Biochemistry, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania, USA 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania, USA 19140","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.832,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.86228122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"2","first_page":"231","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rat-liver-cytosol","display_name":"rat liver cytosol","score":0.8799999952316284},{"id":"https://openalex.org/keywords/deae-cellulose-fractionation","display_name":"DEAE-cellulose fractionation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.4410000145435333},{"id":"https://openalex.org/keywords/cytosolic-proteases","display_name":"cytosolic proteases","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.8446097373962402},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.6943720579147339},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5685823559761047},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.5483931303024292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5427941679954529},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.525542676448822},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5127649903297424},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.49510350823402405},{"id":"https://openalex.org/C97428945","wikidata":"https://www.wikidata.org/wiki/Q15305109","display_name":"Fractionation","level":2,"score":0.46292614936828613},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3360203504562378},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2879396677017212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27755504846572876},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14871037006378174}],"mesh":[{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002848","descriptor_name":"Chromatography, DEAE-Cellulose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014020","descriptor_name":"Tissue Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014222","descriptor_name":"Triamcinolone Acetonide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1432-1033.1983.tb07555.x","doi":"https://doi.org/10.1111/j.1432-1033.1983.tb07555.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1983.tb07555.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:6873061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6873061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W143488173","https://openalex.org/W1481489488","https://openalex.org/W1551722724","https://openalex.org/W1568701525","https://openalex.org/W1574229173","https://openalex.org/W1578995842","https://openalex.org/W1607708211","https://openalex.org/W1896307881","https://openalex.org/W1973154187","https://openalex.org/W1979286967","https://openalex.org/W1986106014","https://openalex.org/W1996154154","https://openalex.org/W2001744408","https://openalex.org/W2014139892","https://openalex.org/W2014744509","https://openalex.org/W2024098392","https://openalex.org/W2042851875","https://openalex.org/W2059181954","https://openalex.org/W2089250490","https://openalex.org/W2118983387","https://openalex.org/W2208707498","https://openalex.org/W2397268206","https://openalex.org/W2410487946"],"related_works":["https://openalex.org/W1909694675","https://openalex.org/W2001744408","https://openalex.org/W1563644794","https://openalex.org/W1541332557","https://openalex.org/W1979286967","https://openalex.org/W2079858846","https://openalex.org/W2022411824","https://openalex.org/W2118983387","https://openalex.org/W2081455213","https://openalex.org/W1881868486"],"abstract_inverted_index":{"We":[0],"have":[1],"identified":[2],"an":[3],"endogenous":[4],"regulator":[5],"of":[6,12,32,67,79],"the":[7,48,53,64,70,88],"glucocorticoid":[8,55],"receptor":[9,56],"following":[10],"fractionation":[11],"dialyzed":[13],"rat":[14],"liver":[15],"cytosol":[16],"on":[17,43],"DEAE-cellulose.":[18],"The":[19,84],"macromolecular":[20],"regulator,":[21],"purified":[22],"approximately":[23],"20-fold":[24],"as":[25],"judged":[26],"by":[27,37,41,69],"Lowry-reactive":[28],"material,":[29],"inhibits":[30],"activation":[31,68],"glucocorticoid-receptor":[33],"complexes":[34],"when":[35],"assayed":[36],"DNA-cellulose":[38],"binding":[39],"and":[40,102],"chromatography":[42],"DEAE-cellulose":[44,50,72],"minicolumns.":[45],"In":[46],"addition":[47],"active":[49,71,89],"fraction":[51,73,90],"stabilizes":[52],"unoccupied":[54],"against":[57],"heat":[58],"inactivation.":[59],"Evidence":[60],"is":[61,74,91,103],"presented":[62],"that":[63],"observed":[65],"inhibition":[66],"not":[75,92],"due":[76],"to":[77,94],"concentration":[78],"cytosolic":[80],"proteases":[81],"or":[82],"RNA.":[83],"inhibitory":[85],"molecule":[86],"in":[87],"stable":[93],"heating":[95],"at":[96,106],"90":[97],"degrees":[98,108],"C":[99,109],"(15":[100],"min)":[101],"partially":[104],"inactivated":[105],"45":[107],"(15-60":[110],"min).":[111]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
