{"id":"https://openalex.org/W2083021997","doi":"https://doi.org/10.1016/s0969-2126(00)00534-7","title":"Insights into Class D \u03b2-Lactamases Are Revealed by the Crystal Structure of the OXA10 Enzyme from Pseudomonas aeruginosa","display_name":"Insights into Class D \u03b2-Lactamases Are Revealed by the Crystal Structure of the OXA10 Enzyme from Pseudomonas aeruginosa","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2083021997","doi":"https://doi.org/10.1016/s0969-2126(00)00534-7","mag":"2083021997","pmid":"https://pubmed.ncbi.nlm.nih.gov/11188693"},"language":"en","primary_location":{"id":"doi:10.1016/s0969-2126(00)00534-7","doi":"https://doi.org/10.1016/s0969-2126(00)00534-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0969-2126(00)00534-7","pdf_url":"http://www.cell.com/article/S0969212600005347/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0969212600005347/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066210282","display_name":"Laurent Maveyraud","orcid":"https://orcid.org/0000-0003-4610-8319","observed_orcids":["https://orcid.org/0000-0003-4610-8319"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099749","display_name":"Institut de Pharmacologie et de Biologie Structurale","ror":"https://ror.org/016zvc994","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Maveyraud","raw_affiliation_strings":["Groupe de Cristallographie Biologique IPBS-CNRS, Toulouse, France","Groupe de Cristallographie Biologique IPBS-CNRS, 205 Route de Narbonne, 31077 Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe de Cristallographie Biologique IPBS-CNRS, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"]},{"raw_affiliation_string":"Groupe de Cristallographie Biologique IPBS-CNRS, 205 Route de Narbonne, 31077 Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086433612","display_name":"Dasantila Golemi","orcid":"https://orcid.org/0000-0003-1299-6987","observed_orcids":["https://orcid.org/0000-0003-1299-6987"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dasantila Golemi","raw_affiliation_strings":["Department of Chemistry Wayne State University Detroit, MI 48202 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Wayne State University Detroit, MI 48202 USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059252438","display_name":"Lakshmi P. Kotra","orcid":"https://orcid.org/0000-0002-7071-4637","observed_orcids":["https://orcid.org/0000-0002-7071-4637"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lakshmi P. Kotra","raw_affiliation_strings":["Department of Chemistry Wayne State University Detroit, MI 48202 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Wayne State University Detroit, MI 48202 USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067999938","display_name":"S. Tranier","orcid":"https://orcid.org/0000-0001-9751-163X","observed_orcids":["https://orcid.org/0000-0001-9751-163X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099749","display_name":"Institut de Pharmacologie et de Biologie Structurale","ror":"https://ror.org/016zvc994","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Samuel Tranier","raw_affiliation_strings":["Groupe de Cristallographie Biologique IPBS-CNRS, 205 Route de Narbonne, 31077 Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe de Cristallographie Biologique IPBS-CNRS, 205 Route de Narbonne, 31077 Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043351423","display_name":"Sergei B. Vakulenko","orcid":"https://orcid.org/0000-0002-5327-8124","observed_orcids":["https://orcid.org/0000-0002-5327-8124"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei Vakulenko","raw_affiliation_strings":["Department of Chemistry Wayne State University Detroit, MI 48202 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Wayne State University Detroit, MI 48202 USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013812375","display_name":"Shahriar Mobashery","orcid":"https://orcid.org/0000-0002-7695-7883","observed_orcids":["https://orcid.org/0000-0002-7695-7883"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahriar Mobashery","raw_affiliation_strings":["Department of Chemistry Wayne State University Detroit, MI 48202 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Wayne State University Detroit, MI 48202 USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111960884","display_name":"Jean\u2010Pierre Samama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099749","display_name":"Institut de Pharmacologie et de Biologie Structurale","ror":"https://ror.org/016zvc994","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Pierre Samama","raw_affiliation_strings":["Groupe de Cristallographie Biologique IPBS-CNRS, 205 Route de Narbonne, 31077 Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe de Cristallographie Biologique IPBS-CNRS, 205 Route de Narbonne, 31077 Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111960884"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":null,"fwci":3.0649,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.91080698,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"12","first_page":"1289","last_page":"1298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/class-d-beta-lactamase","display_name":"class D beta-lactamase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9700000286102295},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.800000011920929},{"id":"https://openalex.org/keywords/enzyme-dimerization","display_name":"enzyme dimerization","score":0.7860000133514404},{"id":"https://openalex.org/keywords/substrate-binding-site","display_name":"substrate binding site","score":0.8389999866485596},{"id":"https://openalex.org/keywords/anion-inhibition","display_name":"anion inhibition","score":0.7850000262260437},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6593633890151978},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6505957841873169},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.580449104309082},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.5511642098426819},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.547539234161377},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5387775301933289},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.43175312876701355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38524502515792847}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002267","descriptor_name":"Muramoylpentapeptide Carboxypeptidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006602","descriptor_name":"Hexosyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010458","descriptor_name":"Peptidyl Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046915","descriptor_name":"Penicillin-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0969-2126(00)00534-7","doi":"https://doi.org/10.1016/s0969-2126(00)00534-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0969-2126(00)00534-7","pdf_url":"http://www.cell.com/article/S0969212600005347/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},{"id":"pmid:11188693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11188693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure (London, England : 1993)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0969-2126(00)00534-7","doi":"https://doi.org/10.1016/s0969-2126(00)00534-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0969-2126(00)00534-7","pdf_url":"http://www.cell.com/article/S0969212600005347/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2083021997.pdf"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W73473199","https://openalex.org/W135437146","https://openalex.org/W198863919","https://openalex.org/W656827624","https://openalex.org/W1581506296","https://openalex.org/W1591680814","https://openalex.org/W1820365410","https://openalex.org/W1870016320","https://openalex.org/W1908427699","https://openalex.org/W1963870808","https://openalex.org/W1965277349","https://openalex.org/W1969181216","https://openalex.org/W1980595924","https://openalex.org/W1985629904","https://openalex.org/W1988958811","https://openalex.org/W1993404146","https://openalex.org/W1996960109","https://openalex.org/W2001641653","https://openalex.org/W2002664017","https://openalex.org/W2014391628","https://openalex.org/W2015304573","https://openalex.org/W2026219411","https://openalex.org/W2031232438","https://openalex.org/W2031772330","https://openalex.org/W2036380814","https://openalex.org/W2038840577","https://openalex.org/W2039388361","https://openalex.org/W2047709322","https://openalex.org/W2057958258","https://openalex.org/W2074112877","https://openalex.org/W2081962393","https://openalex.org/W2089658775","https://openalex.org/W2091679105","https://openalex.org/W2097382368","https://openalex.org/W2101334024","https://openalex.org/W2111516721","https://openalex.org/W2113030266","https://openalex.org/W2122102756","https://openalex.org/W2128577323","https://openalex.org/W2131950041","https://openalex.org/W2133829625","https://openalex.org/W2134253205","https://openalex.org/W2134352676","https://openalex.org/W2139658982","https://openalex.org/W2141254180","https://openalex.org/W2143874510","https://openalex.org/W2147872249","https://openalex.org/W2154771379","https://openalex.org/W2158919479","https://openalex.org/W2163623511","https://openalex.org/W2165414378","https://openalex.org/W2243956032","https://openalex.org/W2280344573","https://openalex.org/W2469024710","https://openalex.org/W2499315139","https://openalex.org/W3023926866","https://openalex.org/W4232928039","https://openalex.org/W4242135481"],"related_works":["https://openalex.org/W1870016320","https://openalex.org/W2085514955","https://openalex.org/W1982897317","https://openalex.org/W2057122523","https://openalex.org/W2171952306","https://openalex.org/W1484459823","https://openalex.org/W1977018354","https://openalex.org/W2042022353","https://openalex.org/W1475117467","https://openalex.org/W6999515681"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
