{"id":"https://openalex.org/W2083020155","doi":"https://doi.org/10.1002/art.10252","title":"Presence of autoantibodies to the glycolytic enzyme \u03b1\u2010enolase in sera from patients with early rheumatoid arthritis","display_name":"Presence of autoantibodies to the glycolytic enzyme \u03b1\u2010enolase in sera from patients with early rheumatoid arthritis","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2083020155","doi":"https://doi.org/10.1002/art.10252","mag":"2083020155","pmid":"https://pubmed.ncbi.nlm.nih.gov/12115223"},"language":"en","primary_location":{"id":"doi:10.1002/art.10252","doi":"https://doi.org/10.1002/art.10252","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.10252","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074831984","display_name":"Vincent Saulot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Saulot","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060019340","display_name":"Olivier Vittecoq","orcid":"https://orcid.org/0000-0001-9268-745X","observed_orcids":["https://orcid.org/0000-0001-9268-745X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210154623","display_name":"Centre Hospitalier Universitaire de Rouen","ror":"https://ror.org/04cdk4t75","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210154623"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Vittecoq","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, and Centre Hospitalier Universitaire de Rouen, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, and Centre Hospitalier Universitaire de Rouen, Rouen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210154623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019116187","display_name":"Roland Charlionet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roland Charlionet","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103178623","display_name":"Patrice Fardellone","orcid":"https://orcid.org/0000-0003-3535-3060","observed_orcids":["https://orcid.org/0000-0003-3535-3060"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrice Fardellone","raw_affiliation_strings":["Centre Hospitalier Universitaire d'Amiens, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire d'Amiens, Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029499585","display_name":"Catherine M. Lange","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Lange","raw_affiliation_strings":["Centre de Spectrom\u00e9trie de Masse, Mont Saint Aignan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Spectrom\u00e9trie de Masse, Mont Saint Aignan, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006556697","display_name":"Laure Marvin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laure Marvin","raw_affiliation_strings":["Centre de Spectrom\u00e9trie de Masse, Mont Saint Aignan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Spectrom\u00e9trie de Masse, Mont Saint Aignan, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078198504","display_name":"Nadine Machour","orcid":"https://orcid.org/0000-0002-8057-8464","observed_orcids":["https://orcid.org/0000-0002-8057-8464"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nadine Machour","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057763735","display_name":"Xavier Le Lo\u00ebt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210154623","display_name":"Centre Hospitalier Universitaire de Rouen","ror":"https://ror.org/04cdk4t75","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210154623"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Le Lo\u00ebt","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, and Centre Hospitalier Universitaire de Rouen, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, and Centre Hospitalier Universitaire de Rouen, Rouen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210154623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111590878","display_name":"Dani\u00e8le Gilbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dani\u00e8le Gilbert","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109140732","display_name":"Fran\u00e7ois Tron","orcid":"https://orcid.org/0009-0005-9169-0944","observed_orcids":["https://orcid.org/0009-0005-9169-0944"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Tron","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Rouen, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5301,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.94950189,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"46","issue":"5","first_page":"1196","last_page":"1201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/enolase-1","display_name":"alpha-enolase","score":0.7720000147819519},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9869999885559082},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.8199999928474426},{"id":"https://openalex.org/keywords/very-early-arthritis","display_name":"very early arthritis","score":0.878000020980835},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6399999856948853},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/radiographic-progression","display_name":"radiographic progression","score":0.8820000290870667},{"id":"https://openalex.org/keywords/glycolytic-enzymes","display_name":"glycolytic enzymes","score":0.7739999890327454},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7930558919906616},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.7335751056671143},{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.5985979437828064},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5863412618637085},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5569733381271362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4954925775527954},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4922596514225006},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4805167615413666},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43031615018844604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33825385570526123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31607586145401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2669990658760071},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1572146713733673},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.10554707050323486},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.10252","doi":"https://doi.org/10.1002/art.10252","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.10252","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},{"id":"pmid:12115223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12115223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310418","display_name":"Association de Recherche sur la Polyarthrite","ror":null},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1582204239","https://openalex.org/W1582982074","https://openalex.org/W1980264776","https://openalex.org/W2019642817","https://openalex.org/W2024400556","https://openalex.org/W2035490152","https://openalex.org/W2065344034","https://openalex.org/W2072619170","https://openalex.org/W2109578241","https://openalex.org/W2113191032","https://openalex.org/W2146616463","https://openalex.org/W2169505673","https://openalex.org/W2277024669","https://openalex.org/W2411723692","https://openalex.org/W2415532012"],"related_works":["https://openalex.org/W3119795578","https://openalex.org/W2116042754","https://openalex.org/W2113191032","https://openalex.org/W2062785609","https://openalex.org/W2023236511","https://openalex.org/W2006547485","https://openalex.org/W1967339290","https://openalex.org/W2277024669","https://openalex.org/W2032112829","https://openalex.org/W1980206759"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"identify":[2],"a":[3,14,39,122,133,140,171,183],"new":[4],"autoantigen/autoantibody":[5],"population":[6],"in":[7,104,206,255,274],"rheumatoid":[8,237],"arthritis":[9,23,62],"(RA)":[10],"sera.":[11,197],"METHODS:":[12],"Following":[13],"population-based":[15],"recruitment":[16],"effort,":[17],"255":[18],"patients":[19,45,232,260,278],"with":[20,174,194,279],"very":[21,280],"early":[22,281],"(median":[24],"disease":[25],"duration":[26],"4":[27],"months)":[28],"were":[29,46,68,95,152,158,233],"studied":[30],"using":[31],"different":[32],"clinical,":[33],"biologic,":[34],"and":[35,60,73,139,157,239,283,287],"radiologic":[36,253],"assessments.":[37],"After":[38],"followup":[40],"period":[41],"of":[42,115,135,143,149,218,227,244,252,268,277],"1":[43],"year,":[44],"classified":[47],"as":[48],"having":[49],"RA":[50,92,118,130,196,201,223,231,259,282],"(n":[51,57,63],"=":[52,58,64],"145),":[53],"non-RA":[54],"rheumatic":[55],"diseases":[56],"70),":[59],"undifferentiated":[61],"40).":[65],"Patients'":[66],"sera":[67,119,131,202,276],"analyzed":[69,82,153],"by":[70,83,102,154],"one-dimensional":[71],"(1D)":[72],"2D":[74,126,187],"Western":[75,112,127,180,188],"blotting.":[76],"The":[77,146,216,242],"recognized":[78,132,170,211],"50-kd":[79,123,176],"protein":[80,100,207],"was":[81,224,247],"matrix-assisted":[84],"laser":[85],"desorption":[86],"ionization-time-of-flight":[87],"(MALDI-TOF)":[88],"mass":[89,142],"spectrometry":[90],"(MS).":[91],"serum":[93],"reactivities":[94],"evaluated":[96],"against":[97],"the":[98,116,150,175,199,212,228,248,256,269,275],"recombinant":[99,213],"synthesized":[101],"an":[103,266],"vitro":[105],"coupled":[106],"transcription-translation":[107],"system.":[108],"RESULTS:":[109],"On":[110,125],"1D":[111,179],"blots,":[113,128,181],"36":[114,200],"145":[117],"bound":[120],"to":[121,160,162,191,264],"polypeptide.":[124],"anti-50-kd+":[129,195],"triplet":[134,151],"isoelectric":[136],"point":[137],"6.5-7.0":[138],"molecular":[141],"50":[144],"kd.":[145],"3":[147],"spots":[148],"MALDI-TOF":[155],"MS":[156],"shown":[159],"correspond":[161],"human":[163],"alpha-enolase.":[164,215],"A":[165],"goat":[166],"anti-enolase":[167],"antiserum,":[168],"which":[169],"band":[172],"comigrating":[173],"antigen":[177],"on":[178,186],"gave":[182],"labeling":[184],"pattern":[185],"blots":[189],"similar":[190],"that":[192,203],"observed":[193],"Among":[198],"identified":[204],"alpha-enolase":[205],"maps,":[208],"only":[209],"8":[210],"(unmodified)":[214],"specificity":[217],"anti-alpha":[219,229],"-enolase":[220],"antibodies":[221,246],"for":[222,235,290],"97.1%.":[225],"Half":[226],"-enolase-positive":[230],"negative":[234],"both":[236],"factor":[238,251],"antifilaggrin":[240],"antibodies.":[241],"presence":[243],"anti-alpha-enolase":[245],"greatest":[249],"predictive":[250],"progression":[254],"first":[257],"66":[258],"included.":[261],"CONCLUSION:":[262],"Autoantibodies":[263],"alpha-enolase,":[265],"enzyme":[267],"glycolytic":[270],"pathway,":[271],"are":[272],"present":[273],"have":[284],"potential":[285],"diagnostic":[286],"prognostic":[288],"value":[289],"RA.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}