{"id":"https://openalex.org/W2082957377","doi":"https://doi.org/10.1074/jbc.m111256200","title":"Factor B and the Mitochondrial ATP Synthase Complex","display_name":"Factor B and the Mitochondrial ATP Synthase Complex","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2082957377","doi":"https://doi.org/10.1074/jbc.m111256200","mag":"2082957377","pmid":"https://pubmed.ncbi.nlm.nih.gov/11744738"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111256200","doi":"https://doi.org/10.1074/jbc.m111256200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111256200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m111256200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089201329","display_name":"Grigory I. Belogrudov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grigory I. Belogrudov","raw_affiliation_strings":["Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088361501","display_name":"Youssef Hatefi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Youssef Hatefi","raw_affiliation_strings":["Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037","From the Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La\u2009Jolla,\u2009California\u200992037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"From the Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La\u2009Jolla,\u2009California\u200992037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088361501"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9562,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.70937676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"277","issue":"8","first_page":"6097","last_page":"6103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-b","display_name":"factor B","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mitochondrial-atp-synthase","display_name":"mitochondrial ATP synthase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/energy-coupling","display_name":"energy coupling","score":0.5830000042915344},{"id":"https://openalex.org/keywords/submitochondrial-particles","display_name":"submitochondrial particles","score":0.9610000252723694},{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cysteine-residues","display_name":"cysteine residues","score":0.9259999990463257},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.8080000281333923},{"id":"https://openalex.org/keywords/protein-subunits","display_name":"protein subunits","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.8349758386611938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6846845746040344},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.6074674129486084},{"id":"https://openalex.org/C60538801","wikidata":"https://www.wikidata.org/wiki/Q7631706","display_name":"Submitochondrial particle","level":3,"score":0.5851261615753174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5344435572624207},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4778320789337158},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.41991183161735535},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37724870443344116},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36941462755203247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35280996561050415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32793793082237244}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009840","descriptor_name":"Oligomycins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m111256200","doi":"https://doi.org/10.1074/jbc.m111256200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111256200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11744738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11744738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111256200","doi":"https://doi.org/10.1074/jbc.m111256200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111256200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W71336344","https://openalex.org/W149787054","https://openalex.org/W218500941","https://openalex.org/W1187436805","https://openalex.org/W1458580723","https://openalex.org/W1498925017","https://openalex.org/W1502468878","https://openalex.org/W1507093689","https://openalex.org/W1540947933","https://openalex.org/W1569758002","https://openalex.org/W1597926281","https://openalex.org/W1964051078","https://openalex.org/W1968401549","https://openalex.org/W1995831465","https://openalex.org/W1999382245","https://openalex.org/W2000285789","https://openalex.org/W2010375907","https://openalex.org/W2011429777","https://openalex.org/W2015465083","https://openalex.org/W2025000003","https://openalex.org/W2028256671","https://openalex.org/W2037138224","https://openalex.org/W2037869037","https://openalex.org/W2045465490","https://openalex.org/W2047504083","https://openalex.org/W2053425784","https://openalex.org/W2059281113","https://openalex.org/W2069098047","https://openalex.org/W2082544726","https://openalex.org/W2083662695","https://openalex.org/W2091696298","https://openalex.org/W2132826785","https://openalex.org/W2158714788","https://openalex.org/W2168909179","https://openalex.org/W2197459119","https://openalex.org/W2410892318","https://openalex.org/W4246150723"],"related_works":["https://openalex.org/W1966129474","https://openalex.org/W2041429755","https://openalex.org/W2041744216","https://openalex.org/W1597926281","https://openalex.org/W2064701815","https://openalex.org/W2117066544","https://openalex.org/W1498925017","https://openalex.org/W1968418763","https://openalex.org/W2060242869","https://openalex.org/W2011429777"],"abstract_inverted_index":{"Factor":[0],"B":[1,41,56,94,112],"is":[2,70,74],"a":[3,25,62],"subunit":[4],"of":[5,24,38,47,65,97,110],"the":[6,19,43,48,107,114],"mammalian":[7,115],"ATP":[8,49,116],"synthase":[9,50,117],"complex,":[10],"whose":[11],"existence":[12],"has":[13,57,100,119],"been":[14,101,120],"controversial.":[15],"This":[16],"paper":[17],"describes":[18],"molecular":[20,63],"and":[21,61,73,78,89,106],"functional":[22,108],"properties":[23],"recombinant":[26],"human":[27,54],"factor":[28,40,55,93,111],"B,":[29],"which":[30],"when":[31],"added":[32],"to":[33],"bovine":[34],"submitochondrial":[35],"particles":[36],"depleted":[37],"their":[39],"restores":[42],"energy":[44],"coupling":[45],"activity":[46],"complexes.":[51],"The":[52,68],"mature":[53],"175":[58],"amino":[59],"acids":[60],"mass":[64],"20,341":[66],"Da.":[67],"preparation":[69],"water-soluble,":[71],"monomeric,":[72],"inactivated":[75],"by":[76],"monothiol-":[77],"especially":[79],"dithiol-modifying":[80],"reagents,":[81],"probably":[82],"reacting":[83],"at":[84],"its":[85],"cysteine":[86],"residues":[87],"Cys-92":[88],"Cys-94.":[90],"A":[91],"likely":[92],"gene":[95],"composed":[96],"5":[98],"exons":[99],"identified":[102],"on":[103],"chromosome":[104],"14q21.3,":[105],"role":[109],"in":[113],"complex":[118],"discussed.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}