{"id":"https://openalex.org/W2082949573","doi":"https://doi.org/10.1152/ajpendo.00558.2014","title":"Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I","display_name":"Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I","publication_year":2015,"publication_date":"2015-02-03","ids":{"openalex":"https://openalex.org/W2082949573","doi":"https://doi.org/10.1152/ajpendo.00558.2014","mag":"2082949573","pmid":"https://pubmed.ncbi.nlm.nih.gov/25648834","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4385875"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00558.2014","doi":"https://doi.org/10.1152/ajpendo.00558.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00558.2014","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4385875","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045990646","display_name":"Adam B. Salmon","orcid":"https://orcid.org/0000-0002-1475-7843","observed_orcids":["https://orcid.org/0000-0002-1475-7843"]},"institutions":[{"id":"https://openalex.org/I2802109968","display_name":"Audie L. Murphy Memorial VA Hospital","ror":"https://ror.org/035xhk118","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802109968","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]},{"id":"https://openalex.org/I4210144081","display_name":"South Texas Veterans Health Care System","ror":"https://ror.org/03n2ay196","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam B. Salmon","raw_affiliation_strings":["Department of Molecular Medicine, and","The Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, Audie L. Murphy Veterans Affairs Hospital, San Antonio, Texas;","The Sam and Ann Barshop Institute for Longevity and Aging Studies,"],"raw_orcid":"https://orcid.org/0000-0002-1475-7843","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, and","institution_ids":[]},{"raw_affiliation_string":"The Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, Audie L. Murphy Veterans Affairs Hospital, San Antonio, Texas;","institution_ids":["https://openalex.org/I2802109968","https://openalex.org/I4210144081"]},{"raw_affiliation_string":"The Sam and Ann Barshop Institute for Longevity and Aging Studies,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074187491","display_name":"Chad A. Lerner","orcid":"https://orcid.org/0000-0002-2463-6658","observed_orcids":["https://orcid.org/0000-0002-2463-6658"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad Lerner","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086992632","display_name":"Yuji Ikeno","orcid":"https://orcid.org/0000-0002-9234-8738","observed_orcids":["https://orcid.org/0000-0002-9234-8738"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I2802109968","display_name":"Audie L. Murphy Memorial VA Hospital","ror":"https://ror.org/035xhk118","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802109968","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]},{"id":"https://openalex.org/I4210144081","display_name":"South Texas Veterans Health Care System","ror":"https://ror.org/03n2ay196","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuji Ikeno","raw_affiliation_strings":["Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas;","The Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, Audie L. Murphy Veterans Affairs Hospital, San Antonio, Texas;","The Sam and Ann Barshop Institute for Longevity and Aging Studies,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas;","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"The Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, Audie L. Murphy Veterans Affairs Hospital, San Antonio, Texas;","institution_ids":["https://openalex.org/I2802109968","https://openalex.org/I4210144081"]},{"raw_affiliation_string":"The Sam and Ann Barshop Institute for Longevity and Aging Studies,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077835125","display_name":"Susan M. Motch Perrine","orcid":"https://orcid.org/0000-0003-3412-221X","observed_orcids":["https://orcid.org/0000-0003-3412-221X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan M. Motch Perrine","raw_affiliation_strings":["Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania; and","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013049594","display_name":"Roger McCarter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger McCarter","raw_affiliation_strings":["Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038670151","display_name":"Christian Sell","orcid":"https://orcid.org/0000-0002-4332-1141","observed_orcids":["https://orcid.org/0000-0002-4332-1141"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Sell","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5045990646"],"corresponding_institution_ids":["https://openalex.org/I2802109968","https://openalex.org/I4210144081"],"apc_list":null,"apc_paid":null,"fwci":2.8931,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.91247931,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"308","issue":"7","first_page":"E545","last_page":"E553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.06790000200271606,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9549999833106995},{"id":"https://openalex.org/keywords/igf-1-deficiency","display_name":"IGF-1 deficiency","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.609000027179718},{"id":"https://openalex.org/keywords/obesity-resistance","display_name":"obesity resistance","score":0.7490000128746033},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8289999961853027},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8640000224113464},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/fatty-acid-utilization","display_name":"fatty acid utilization","score":0.7310000061988831},{"id":"https://openalex.org/keywords/respiratory-quotient","display_name":"respiratory quotient","score":0.8339999914169312},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8339999914169312},{"id":"https://openalex.org/keywords/female-mice","display_name":"female mice","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.878628134727478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8744099140167236},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7153123617172241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6664543747901917},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5833206176757812},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5730571746826172},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.48097479343414307},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4661620259284973},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.45823007822036743},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4401153326034546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18866214156150818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13581374287605286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060467","descriptor_name":"Disease Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpendo.00558.2014","doi":"https://doi.org/10.1152/ajpendo.00558.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00558.2014","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4385875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4385875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Endocrinol Metab","raw_type":"Text"},{"id":"pmid:25648834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25648834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4385875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4385875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Endocrinol Metab","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1238683242","display_name":null,"funder_award_id":"AG-02243","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G67177749","display_name":null,"funder_award_id":"AG223343","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8659715656","display_name":"Training Grant on the Biology of Aging","funder_award_id":"T32AG021890","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306228","display_name":"American Federation for Aging Research","ror":"https://ror.org/000r61a05"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1566575087","https://openalex.org/W1832860099","https://openalex.org/W1901547630","https://openalex.org/W1970742074","https://openalex.org/W1982836278","https://openalex.org/W1984538328","https://openalex.org/W1985425785","https://openalex.org/W1998569023","https://openalex.org/W2023161917","https://openalex.org/W2027738823","https://openalex.org/W2028551167","https://openalex.org/W2030729252","https://openalex.org/W2036248520","https://openalex.org/W2040461176","https://openalex.org/W2040529605","https://openalex.org/W2041032395","https://openalex.org/W2048408454","https://openalex.org/W2049009766","https://openalex.org/W2054121324","https://openalex.org/W2056504539","https://openalex.org/W2057913302","https://openalex.org/W2062629127","https://openalex.org/W2063098376","https://openalex.org/W2063114187","https://openalex.org/W2064963145","https://openalex.org/W2066519654","https://openalex.org/W2072013077","https://openalex.org/W2072026063","https://openalex.org/W2079675008","https://openalex.org/W2083699927","https://openalex.org/W2086532922","https://openalex.org/W2090663991","https://openalex.org/W2097535790","https://openalex.org/W2098690642","https://openalex.org/W2101697574","https://openalex.org/W2102123572","https://openalex.org/W2104632795","https://openalex.org/W2107674876","https://openalex.org/W2115140038","https://openalex.org/W2115709321","https://openalex.org/W2139499592","https://openalex.org/W2139908485","https://openalex.org/W2140409043","https://openalex.org/W2142531099","https://openalex.org/W2147247395","https://openalex.org/W2148288112","https://openalex.org/W2149388099","https://openalex.org/W2151390490","https://openalex.org/W2154635769","https://openalex.org/W2159229996","https://openalex.org/W2159664830","https://openalex.org/W2166307667","https://openalex.org/W2170962847","https://openalex.org/W2171012377"],"related_works":["https://openalex.org/W4306947985","https://openalex.org/W2603416940","https://openalex.org/W2034832031","https://openalex.org/W2299046420","https://openalex.org/W1981574344","https://openalex.org/W4308134486","https://openalex.org/W2092430835","https://openalex.org/W1986441153","https://openalex.org/W2127610889","https://openalex.org/W3177246663"],"abstract_inverted_index":{"The":[0],"extension":[1,48],"of":[2,41,49,59,154,214],"lifespan":[3],"due":[4],"to":[5,18,72,144,210],"reduced":[6,39],"insulin-like":[7],"growth":[8],"factor":[9],"1":[10],"(IGF-I)":[11],"signaling":[12],"in":[13,23,34,70,129,139,186,198],"mice":[14,29,80,96,123,142,166,200],"has":[15],"been":[16],"proposed":[17],"be":[19],"mediated":[20],"through":[21],"alterations":[22],"metabolism.":[24],"Previously,":[25],"we":[26,53],"showed":[27,124],"that":[28,77,163,184,201],"homozygous":[30],"for":[31],"an":[32,47,91,172],"insertion":[33],"the":[35,140,164,187,211],"Igf1":[36],"allele":[37],"have":[38,46],"levels":[40,192],"IGF-I,":[42],"are":[43],"smaller,":[44],"and":[45,69,149,156,189],"maximum":[50],"lifespan.":[51],"Here,":[52],"tested":[54],"whether":[55],"this":[56],"specific":[57],"reduction":[58,185],"IGF-I":[60,191],"alters":[61],"glucose":[62],"metabolism":[63,155],"both":[64,147],"on":[65,83,106,146,177],"normal":[66,102,148],"rodent":[67,86],"chow":[68],"response":[71,114,131],"high-fat":[73,108,119,133,150,179,215],"feeding.":[74,134,216],"We":[75],"found":[76],"female":[78,199],"IGF-I-deficient":[79,122,141,165],"were":[81],"lean":[82],"a":[84,107,125,178,195],"standard":[85],"diet":[87],"but":[88,206],"paradoxically":[89],"displayed":[90],"insulin-resistant":[92],"phenotype.":[93],"However,":[94],"these":[95],"gained":[97],"significantly":[98,116],"less":[99],"weight":[100],"than":[101],"controls":[103,145],"when":[104,175],"placed":[105,176],"diet.":[109,151,180],"In":[110],"control":[111],"animals,":[112],"insulin":[113,130,204],"was":[115,136],"impaired":[117],"by":[118],"feeding,":[120],"whereas":[121],"much":[126],"smaller":[127],"shift":[128],"after":[132],"Gluconeogenesis":[135],"also":[137],"elevated":[138],"relative":[143],"An":[152],"analysis":[153],"respiratory":[157],"quotient":[158],"over":[159],"24":[160],"h":[161],"indicated":[162],"preferentially":[167],"utilized":[168],"fatty":[169],"acids":[170],"as":[171],"energy":[173],"source":[174],"These":[181],"results":[182],"indicate":[183],"circulating":[188],"tissue":[190],"can":[193],"produce":[194],"metabolic":[196],"phenotype":[197],"increases":[202],"peripheral":[203],"resistance":[205],"renders":[207],"animals":[208],"resistant":[209],"deleterious":[212],"effects":[213]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}