{"id":"https://openalex.org/W2082934471","doi":"https://doi.org/10.1016/j.jphotobiol.2007.09.007","title":"Near-ultraviolet photolysis of \u03b2-phenylpyruvic acid generates free radicals and results in DNA damage","display_name":"Near-ultraviolet photolysis of \u03b2-phenylpyruvic acid generates free radicals and results in DNA damage","publication_year":2007,"publication_date":"2007-09-21","ids":{"openalex":"https://openalex.org/W2082934471","doi":"https://doi.org/10.1016/j.jphotobiol.2007.09.007","mag":"2082934471","pmid":"https://pubmed.ncbi.nlm.nih.gov/17977740"},"language":"en","primary_location":{"id":"doi:10.1016/j.jphotobiol.2007.09.007","doi":"https://doi.org/10.1016/j.jphotobiol.2007.09.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jphotobiol.2007.09.007","pdf_url":null,"source":{"id":"https://openalex.org/S148303206","display_name":"Journal of Photochemistry and Photobiology B Biology","issn_l":"1011-1344","issn":["1011-1344","1873-2682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Photochemistry and Photobiology B: Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040035010","display_name":"Alan Jeffrey Hargreaves","orcid":"https://orcid.org/0000-0001-9754-5477","observed_orcids":["https://orcid.org/0000-0001-9754-5477"]},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Hargreaves","raw_affiliation_strings":["School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK","institution_ids":["https://openalex.org/I52590639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060697516","display_name":"Fatai A. Taiwo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66943878","display_name":"De Montfort University","ror":"https://ror.org/0312pnr83","country_code":"GB","type":"education","lineage":["https://openalex.org/I66943878"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F.A. Taiwo","raw_affiliation_strings":["School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK","institution_ids":["https://openalex.org/I66943878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067584231","display_name":"Orla Duggan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"O. Duggan","raw_affiliation_strings":["School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK","institution_ids":["https://openalex.org/I52590639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062975996","display_name":"Sandra H. Kirk","orcid":"https://orcid.org/0000-0003-1899-7059","observed_orcids":["https://orcid.org/0000-0003-1899-7059"]},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S.H. Kirk","raw_affiliation_strings":["School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK","institution_ids":["https://openalex.org/I52590639"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019536560","display_name":"Shamim Ahmad","orcid":"https://orcid.org/0000-0003-1546-3959","observed_orcids":["https://orcid.org/0000-0003-1546-3959"]},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"S.I. Ahmad","raw_affiliation_strings":["School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK","institution_ids":["https://openalex.org/I52590639"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019536560"],"corresponding_institution_ids":["https://openalex.org/I52590639"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":1.0256,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.72160804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"89","issue":"2-3","first_page":"110","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.1736000031232834,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.1736000031232834,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.09319999814033508,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uva-radiation","display_name":"UVA","score":0.7760000228881836},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.7570000290870667},{"id":"https://openalex.org/keywords/carboxyl-radical","display_name":"carboxyl radical","score":0.902999997138977},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.925000011920929},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7879999876022339},{"id":"https://openalex.org/keywords/phenylketonuria","display_name":"phenylketonuria","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.8749029636383057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8480613231658936},{"id":"https://openalex.org/C2777303428","wikidata":"https://www.wikidata.org/wiki/Q425030","display_name":"Phenylpyruvic acid","level":4,"score":0.7612240314483643},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.6796178221702576},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.6023265719413757},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5942164659500122},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5221917033195496},{"id":"https://openalex.org/C54582936","wikidata":"https://www.wikidata.org/wiki/Q16814","display_name":"Photodissociation","level":2,"score":0.504531741142273},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.4694865345954895},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4512459933757782},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28830188512802124},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2283484935760498},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1945851743221283},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15192469954490662}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010667","descriptor_name":"Phenylpyruvic Acids","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D010782","descriptor_name":"Photolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017123","descriptor_name":"Bacteriophage T7","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jphotobiol.2007.09.007","doi":"https://doi.org/10.1016/j.jphotobiol.2007.09.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jphotobiol.2007.09.007","pdf_url":null,"source":{"id":"https://openalex.org/S148303206","display_name":"Journal of Photochemistry and Photobiology B Biology","issn_l":"1011-1344","issn":["1011-1344","1873-2682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Photochemistry and Photobiology B: Biology","raw_type":"journal-article"},{"id":"pmid:17977740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17977740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of photochemistry and photobiology. B, Biology","raw_type":"Journal Article"},{"id":"pmh:oai:irep.ntu.ac.uk:16349","doi":null,"is_oa":false,"landing_page_url":"http://irep.ntu.ac.uk/id/eprint/16349/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400559","display_name":"Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52590639","host_organization_name":"Nottingham Trent University","host_organization_lineage":["https://openalex.org/I52590639"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320180","display_name":"De Montfort University","ror":"https://ror.org/0312pnr83"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W4082156","https://openalex.org/W357827627","https://openalex.org/W1562810615","https://openalex.org/W1590200004","https://openalex.org/W1968499584","https://openalex.org/W1974425878","https://openalex.org/W1975856550","https://openalex.org/W1978638781","https://openalex.org/W1997341514","https://openalex.org/W2007010947","https://openalex.org/W2009684333","https://openalex.org/W2016585187","https://openalex.org/W2020418983","https://openalex.org/W2024921655","https://openalex.org/W2030032607","https://openalex.org/W2034129646","https://openalex.org/W2035966771","https://openalex.org/W2036276469","https://openalex.org/W2048607797","https://openalex.org/W2050522578","https://openalex.org/W2052201603","https://openalex.org/W2058138894","https://openalex.org/W2062603557","https://openalex.org/W2067139494","https://openalex.org/W2069725001","https://openalex.org/W2072150734","https://openalex.org/W2072935224","https://openalex.org/W2083754582","https://openalex.org/W2084104068","https://openalex.org/W2089243368","https://openalex.org/W2092629964","https://openalex.org/W2092721974","https://openalex.org/W2093677834","https://openalex.org/W2147206627","https://openalex.org/W2150005825","https://openalex.org/W2326225745","https://openalex.org/W2417790788","https://openalex.org/W2461818675","https://openalex.org/W3108525176","https://openalex.org/W4402019762"],"related_works":["https://openalex.org/W3109974506","https://openalex.org/W2050522578","https://openalex.org/W1974425878","https://openalex.org/W1972086279","https://openalex.org/W2063197854","https://openalex.org/W2072935224","https://openalex.org/W6997086212","https://openalex.org/W2058117310","https://openalex.org/W4392565238","https://openalex.org/W7120798951"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}