{"id":"https://openalex.org/W2082885292","doi":"https://doi.org/10.1038/srep03451","title":"Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces","display_name":"Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces","publication_year":2013,"publication_date":"2013-12-13","ids":{"openalex":"https://openalex.org/W2082885292","doi":"https://doi.org/10.1038/srep03451","mag":"2082885292","pmid":"https://pubmed.ncbi.nlm.nih.gov/24336354","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6506440"},"language":"en","primary_location":{"id":"doi:10.1038/srep03451","doi":"https://doi.org/10.1038/srep03451","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep03451","pdf_url":"https://www.nature.com/articles/srep03451.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep03451.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014197733","display_name":"Dilraj Lama","orcid":"https://orcid.org/0000-0001-8603-9368","observed_orcids":["https://orcid.org/0000-0001-8603-9368"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Dilraj Lama","raw_affiliation_strings":["1] Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore 138671 [2]","Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, 138671, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore 138671 [2]","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]},{"raw_affiliation_string":"Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, 138671, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113738655","display_name":"Soo Tng Quah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Soo T. Quah","raw_affiliation_strings":["1] p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648 [2]","p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05 Neuros/Immunos, 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648 [2]","institution_ids":["https://openalex.org/I115228651"]},{"raw_affiliation_string":"p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05 Neuros/Immunos, 138648, Singapore","institution_ids":["https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045760818","display_name":"Chandra Shekhar Verma","orcid":"https://orcid.org/0000-0003-0733-9798","observed_orcids":["https://orcid.org/0000-0003-0733-9798","https://orcid.org/0000-0003-2319-9510"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Chandra S. Verma","raw_affiliation_strings":["1] Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore 138671 [2] Department of Biological sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 [3] School of Biological sciences, Nanyang Technological University, 50 Nanyang Drive, Singapore 637551","Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, 138671, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, Singapore 138671 [2] Department of Biological sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 [3] School of Biological sciences, Nanyang Technological University, 50 Nanyang Drive, Singapore 637551","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I165932596","https://openalex.org/I172675005","https://openalex.org/I4210148498"]},{"raw_affiliation_string":"Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), 30 Biopolis Street, #07-01 Matrix, 138671, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035157534","display_name":"Rajamani Lakshminarayanan","orcid":"https://orcid.org/0000-0001-8214-5315","observed_orcids":["https://orcid.org/0000-0001-8214-5315"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Rajamani Lakshminarayanan","raw_affiliation_strings":["Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 16875","Singapore Eye Research Institute, 11 Third Hospital Avenue, 16875, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 16875","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, 16875, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Roger W. Beuerman","raw_affiliation_strings":["Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 16875","Singapore Eye Research Institute, 11 Third Hospital Avenue, 16875, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 16875","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, 16875, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019407635","display_name":"David Philip Lane","orcid":"https://orcid.org/0000-0003-0551-3545","observed_orcids":["https://orcid.org/0000-0003-0551-3545","https://orcid.org/0000-0003-4283-3695"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"David P. Lane","raw_affiliation_strings":["p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648","p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05 Neuros/Immunos, 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648","institution_ids":["https://openalex.org/I115228651"]},{"raw_affiliation_string":"p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05 Neuros/Immunos, 138648, Singapore","institution_ids":["https://openalex.org/I115228651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070284125","display_name":"Christopher John Brown","orcid":"https://orcid.org/0000-0001-8425-534X","observed_orcids":["https://orcid.org/0000-0001-8425-534X"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Christopher J. Brown","raw_affiliation_strings":["p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648","p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05 Neuros/Immunos, 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, Singapore 138648","institution_ids":["https://openalex.org/I115228651"]},{"raw_affiliation_string":"p53 Laboratory, A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove, #06-04/05 Neuros/Immunos, 138648, Singapore","institution_ids":["https://openalex.org/I115228651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5045760818","https://openalex.org/A5070284125"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I165932596","https://openalex.org/I172675005","https://openalex.org/I4210148498"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.8104,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.90541263,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"3451","last_page":"3451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.1800999939441681,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stapled-peptides","display_name":"stapled peptides","score":0.9070000052452087},{"id":"https://openalex.org/keywords/eif4e","display_name":"eIF4E","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cap-dependent-translation","display_name":"cap-dependent translation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/protein-protein-interaction-inhibitors","display_name":"protein-protein interaction inhibitors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.7129999995231628},{"id":"https://openalex.org/keywords/structural-clustering","display_name":"structural clustering","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2776054693","wikidata":"https://www.wikidata.org/wiki/Q5323186","display_name":"EIF4G","level":5,"score":0.7099634408950806},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6101452112197876},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6071969866752625},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.58717280626297},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5851777791976929},{"id":"https://openalex.org/C161295673","wikidata":"https://www.wikidata.org/wiki/Q5408696","display_name":"EIF4E","level":5,"score":0.5676435828208923},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.5390602350234985},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5143052339553833},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4569578170776367},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.44431209564208984},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.43920961022377014},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4200626015663147},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.41373899579048157},{"id":"https://openalex.org/C2777936996","wikidata":"https://www.wikidata.org/wiki/Q17148461","display_name":"Conformational ensembles","level":3,"score":0.4113411009311676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3964989483356476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29940396547317505},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15740886330604553},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.14181053638458252},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10666978359222412},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09341585636138916},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.09133455157279968}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006838","descriptor_name":"Hydrocarbons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039561","descriptor_name":"Eukaryotic Initiation Factor-4E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039561","descriptor_name":"Eukaryotic Initiation Factor-4E","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D039603","descriptor_name":"Eukaryotic Initiation Factor-4G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039603","descriptor_name":"Eukaryotic Initiation Factor-4G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/srep03451","doi":"https://doi.org/10.1038/srep03451","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep03451","pdf_url":"https://www.nature.com/articles/srep03451.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6506440","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6506440","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:24336354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24336354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/101527","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/101527","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/101384","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10220/18637","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/srep03451","doi":"https://doi.org/10.1038/srep03451","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep03451","pdf_url":"https://www.nature.com/articles/srep03451.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082885292.pdf","grobid_xml":"https://content.openalex.org/works/W2082885292.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W137428939","https://openalex.org/W255996521","https://openalex.org/W1551855406","https://openalex.org/W1560481517","https://openalex.org/W1964675052","https://openalex.org/W1965198797","https://openalex.org/W1968984443","https://openalex.org/W1971495173","https://openalex.org/W1974431355","https://openalex.org/W1976430096","https://openalex.org/W1976499671","https://openalex.org/W1993520503","https://openalex.org/W1994317932","https://openalex.org/W1994941561","https://openalex.org/W1998755101","https://openalex.org/W2007763435","https://openalex.org/W2008845432","https://openalex.org/W2011948013","https://openalex.org/W2015532290","https://openalex.org/W2024582587","https://openalex.org/W2035266068","https://openalex.org/W2045583352","https://openalex.org/W2054731547","https://openalex.org/W2060158924","https://openalex.org/W2061791098","https://openalex.org/W2064743401","https://openalex.org/W2065671628","https://openalex.org/W2067174909","https://openalex.org/W2071586142","https://openalex.org/W2083164919","https://openalex.org/W2094130001","https://openalex.org/W2097933346","https://openalex.org/W2106140689","https://openalex.org/W2106799894","https://openalex.org/W2108004255","https://openalex.org/W2118233996","https://openalex.org/W2134544924","https://openalex.org/W2144288821","https://openalex.org/W2144975103","https://openalex.org/W2159010139","https://openalex.org/W2160079255","https://openalex.org/W2163915395","https://openalex.org/W2164270482","https://openalex.org/W2167029191"],"related_works":["https://openalex.org/W2908067206","https://openalex.org/W2942721876","https://openalex.org/W2396692980","https://openalex.org/W3044507822","https://openalex.org/W2949286865","https://openalex.org/W3135725024","https://openalex.org/W2045583352","https://openalex.org/W1994317932","https://openalex.org/W4220918984","https://openalex.org/W2997555476"],"abstract_inverted_index":{"eIF4E":[0],"is":[1],"frequently":[2],"over-expressed":[3],"in":[4,59,62,86,92,143],"different":[5],"cancers":[6],"and":[7,61,69,132,135],"causes":[8],"increased":[9],"translation":[10],"of":[11,19,37,54,73,82,130],"oncogenic":[12],"proteins":[13],"via":[14],"deregulated":[15],"cap-dependent":[16,29],"translation.":[17,30],"Inhibitors":[18],"the":[20,74,78,83,110,121,128],"eIF4E:eIF4G":[21],"interactions":[22],"represent":[23,33],"an":[24,34],"approach":[25],"that":[26,39,123,137],"would":[27],"normalize":[28],"Stapled":[31],"peptides":[32,58,85,102],"emerging":[35],"class":[36],"therapeutics":[38],"can":[40],"target":[41],"protein:":[42],"protein":[43],"interactions.":[44],"We":[45],"present":[46],"here":[47],"molecular":[48],"dynamics":[49],"simulations":[50],"for":[51],"a":[52],"set":[53],"rationally":[55],"designed":[56],"stapled":[57,84],"solution":[60],"complex":[63],"with":[64,67,103],"eIF4E,":[65],"supported":[66],"biophysical":[68],"crystallographic":[70],"data.":[71],"Clustering":[72],"simulated":[75],"structures":[76],"revealed":[77],"favoured":[79],"conformational":[80,116],"states":[81,139],"their":[87,115],"bound":[88,133],"or":[89],"free":[90,131],"forms":[91],"solution.":[93],"Identifying":[94],"these":[95],"populations":[96],"has":[97],"allowed":[98],"us":[99],"to":[100,113,145],"design":[101],"improved":[104],"affinities":[105],"by":[106],"introducing":[107],"mutations":[108,125],"into":[109],"peptide":[111],"sequence":[112],"alter":[114],"distributions.":[117],"These":[118],"studies":[119],"emphasise":[120],"effects":[122],"engineered":[124],"have":[126],"on":[127],"conformations":[129],"peptides,":[134],"illustrate":[136],"both":[138],"must":[140],"be":[141],"considered":[142],"efforts":[144],"attain":[146],"high":[147],"affinity":[148],"binding.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
