{"id":"https://openalex.org/W2082883706","doi":"https://doi.org/10.1016/j.molimm.2013.06.001","title":"Complement factor H related proteins (CFHRs)","display_name":"Complement factor H related proteins (CFHRs)","publication_year":2013,"publication_date":"2013-07-04","ids":{"openalex":"https://openalex.org/W2082883706","doi":"https://doi.org/10.1016/j.molimm.2013.06.001","mag":"2082883706","pmid":"https://pubmed.ncbi.nlm.nih.gov/23830046"},"language":"en","primary_location":{"id":"doi:10.1016/j.molimm.2013.06.001","doi":"https://doi.org/10.1016/j.molimm.2013.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molimm.2013.06.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0161589013004185/pdf","source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0161589013004185/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074615051","display_name":"Christine Skerka","orcid":"https://orcid.org/0000-0003-2374-6473","observed_orcids":["https://orcid.org/0000-0003-2374-6473"]},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christine Skerka","raw_affiliation_strings":["Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany. christine.skerka@hki-jena.de","Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany. christine.skerka@hki-jena.de","institution_ids":["https://openalex.org/I4210162077"]},{"raw_affiliation_string":"Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qian Chen","raw_affiliation_strings":["Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025683973","display_name":"V\u00e9ronique Fr\u00e9meaux\u2010Bacchi","orcid":"https://orcid.org/0000-0002-4865-8528","observed_orcids":["https://orcid.org/0000-0002-4865-8528"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Veronique Fremeaux-Bacchi","raw_affiliation_strings":["Centre de Recherche des Cordeliers, INSERM UMRS 872, Paris, France","Service d\u2019Immunologie Biologique, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, INSERM UMRS 872, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Service d\u2019Immunologie Biologique, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France","institution_ids":["https://openalex.org/I4210102325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051276814","display_name":"Lubka T. Roumenina","orcid":"https://orcid.org/0000-0002-9940-0324","observed_orcids":["https://orcid.org/0000-0002-9940-0324"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lubka T. Roumenina","raw_affiliation_strings":["Centre de Recherche des Cordeliers, INSERM UMRS 872, Paris, France","Universit\u00e9 Paris Descartes Sorbonne Paris-Cit\u00e9, Paris, France","Universit\u00e9 Pierre et Marie Curie (UPMC-Paris-6), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, INSERM UMRS 872, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes Sorbonne Paris-Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie (UPMC-Paris-6), Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5074615051"],"corresponding_institution_ids":["https://openalex.org/I4210162077"],"apc_list":{"value":3340,"currency":"USD","value_usd":3340},"apc_paid":{"value":3340,"currency":"USD","value_usd":3340},"fwci":1.975,"has_fulltext":true,"cited_by_count":280,"citation_normalized_percentile":{"value":0.89558614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"56","issue":"3","first_page":"170","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-factor-h-related-proteins","display_name":"complement factor H-related proteins","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cfhr1","display_name":"CFHR1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cfhr3","display_name":"CFHR3","score":1.0},{"id":"https://openalex.org/keywords/cfhr5","display_name":"CFHR5","score":1.0},{"id":"https://openalex.org/keywords/c3b","display_name":"C3b","score":0.6940000057220459},{"id":"https://openalex.org/keywords/complement-regulation","display_name":"complement regulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/atypical-hemolytic-uremic-syndrome","display_name":"atypical hemolytic uremic syndrome","score":0.9739999771118164},{"id":"https://openalex.org/keywords/c3-glomerulonephritis","display_name":"C3 glomerulonephritis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dense-deposit-disease","display_name":"dense deposit disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iga-nephropathy","display_name":"IgA nephropathy","score":1.0},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9559999704360962},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hybrid-proteins","display_name":"hybrid proteins","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C14356644","wikidata":"https://www.wikidata.org/wiki/Q14911975","display_name":"Factor H","level":4,"score":0.7973471879959106},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.7645328044891357},{"id":"https://openalex.org/C179369057","wikidata":"https://www.wikidata.org/wiki/Q20970075","display_name":"Complement factor I","level":4,"score":0.7113239765167236},{"id":"https://openalex.org/C2777637130","wikidata":"https://www.wikidata.org/wiki/Q17165460","display_name":"Atypical hemolytic uremic syndrome","level":4,"score":0.688144326210022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5665261149406433},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5602545142173767},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.534668505191803},{"id":"https://openalex.org/C182629451","wikidata":"https://www.wikidata.org/wiki/Q18251054","display_name":"Complement factor B","level":4,"score":0.5313459038734436},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.5271177887916565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5243744850158691},{"id":"https://openalex.org/C136015124","wikidata":"https://www.wikidata.org/wiki/Q13566093","display_name":"Complement component 2","level":5,"score":0.5207757353782654},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5160031318664551},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.47655680775642395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4179019033908844},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2989882528781891},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.08436107635498047},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.07706403732299805},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081208","descriptor_name":"Hereditary Complement Deficiency Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003180","descriptor_name":"Complement C3b Inactivator Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003180","descriptor_name":"Complement C3b Inactivator Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003180","descriptor_name":"Complement C3b Inactivator Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006463","descriptor_name":"Hemolytic-Uremic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006463","descriptor_name":"Hemolytic-Uremic Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015432","descriptor_name":"Glomerulonephritis, Membranoproliferative","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015432","descriptor_name":"Glomerulonephritis, Membranoproliferative","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.molimm.2013.06.001","doi":"https://doi.org/10.1016/j.molimm.2013.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molimm.2013.06.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0161589013004185/pdf","source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},{"id":"pmid:23830046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23830046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.molimm.2013.06.001","doi":"https://doi.org/10.1016/j.molimm.2013.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molimm.2013.06.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0161589013004185/pdf","source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1331116799","display_name":"European Consortium for High-Throughput Research in Rare Kidney Diseases","funder_award_id":"305608","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3447123006","display_name":null,"funder_award_id":"DFG SK-46","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082883706.pdf","grobid_xml":"https://content.openalex.org/works/W2082883706.grobid-xml"},"referenced_works_count":118,"referenced_works":["https://openalex.org/W121687570","https://openalex.org/W315197452","https://openalex.org/W1492585433","https://openalex.org/W1497433478","https://openalex.org/W1519481032","https://openalex.org/W1523487120","https://openalex.org/W1534759813","https://openalex.org/W1564844664","https://openalex.org/W1567841187","https://openalex.org/W1591126651","https://openalex.org/W1615621128","https://openalex.org/W1675921820","https://openalex.org/W1795721684","https://openalex.org/W1835181906","https://openalex.org/W1965972308","https://openalex.org/W1966462935","https://openalex.org/W1969977195","https://openalex.org/W1971052994","https://openalex.org/W1974010028","https://openalex.org/W1977035416","https://openalex.org/W1977663109","https://openalex.org/W1978057155","https://openalex.org/W1986909164","https://openalex.org/W1991404512","https://openalex.org/W1994071473","https://openalex.org/W1995813318","https://openalex.org/W1997761753","https://openalex.org/W2000822340","https://openalex.org/W2003796699","https://openalex.org/W2005998863","https://openalex.org/W2006207298","https://openalex.org/W2006662979","https://openalex.org/W2008173634","https://openalex.org/W2008607429","https://openalex.org/W2010448151","https://openalex.org/W2014498995","https://openalex.org/W2015242897","https://openalex.org/W2017695801","https://openalex.org/W2017907569","https://openalex.org/W2021691030","https://openalex.org/W2024751825","https://openalex.org/W2026192625","https://openalex.org/W2028194487","https://openalex.org/W2029886021","https://openalex.org/W2033167260","https://openalex.org/W2033189690","https://openalex.org/W2035310463","https://openalex.org/W2036607489","https://openalex.org/W2037699290","https://openalex.org/W2050217807","https://openalex.org/W2052204842","https://openalex.org/W2052521611","https://openalex.org/W2054101977","https://openalex.org/W2056159723","https://openalex.org/W2059726023","https://openalex.org/W2062097745","https://openalex.org/W2063874378","https://openalex.org/W2065819475","https://openalex.org/W2066019882","https://openalex.org/W2067053006","https://openalex.org/W2068743916","https://openalex.org/W2070384620","https://openalex.org/W2077144266","https://openalex.org/W2078020531","https://openalex.org/W2078820067","https://openalex.org/W2079362912","https://openalex.org/W2079648119","https://openalex.org/W2080583506","https://openalex.org/W2080636057","https://openalex.org/W2081046636","https://openalex.org/W2085547270","https://openalex.org/W2087387372","https://openalex.org/W2088551743","https://openalex.org/W2092957542","https://openalex.org/W2094470709","https://openalex.org/W2097013149","https://openalex.org/W2097802875","https://openalex.org/W2098315002","https://openalex.org/W2098613222","https://openalex.org/W2100963035","https://openalex.org/W2106523804","https://openalex.org/W2106675927","https://openalex.org/W2107932619","https://openalex.org/W2108666080","https://openalex.org/W2110795913","https://openalex.org/W2113355604","https://openalex.org/W2113648585","https://openalex.org/W2114983857","https://openalex.org/W2119057191","https://openalex.org/W2119210020","https://openalex.org/W2120550056","https://openalex.org/W2120618976","https://openalex.org/W2122311517","https://openalex.org/W2122387757","https://openalex.org/W2126092981","https://openalex.org/W2127724039","https://openalex.org/W2130503929","https://openalex.org/W2136438837","https://openalex.org/W2136648677","https://openalex.org/W2139277245","https://openalex.org/W2139588645","https://openalex.org/W2143082949","https://openalex.org/W2143620060","https://openalex.org/W2145009441","https://openalex.org/W2151027431","https://openalex.org/W2151498748","https://openalex.org/W2154607428","https://openalex.org/W2158009625","https://openalex.org/W2161469264","https://openalex.org/W2163064289","https://openalex.org/W2166011542","https://openalex.org/W2170178363","https://openalex.org/W2171450842","https://openalex.org/W2172106052","https://openalex.org/W2177078605","https://openalex.org/W2292968055","https://openalex.org/W2395525054","https://openalex.org/W6697255675"],"related_works":["https://openalex.org/W140502166","https://openalex.org/W2000375736","https://openalex.org/W2770657816","https://openalex.org/W2124670403","https://openalex.org/W1971052994","https://openalex.org/W2139588645","https://openalex.org/W3001004552","https://openalex.org/W4413236790","https://openalex.org/W1966820620","https://openalex.org/W7009387101"],"abstract_inverted_index":{"Factor":[0],"H":[1],"related":[2,69],"proteins":[3,119,137,158,168],"comprise":[4],"a":[5,44],"group":[6,22],"of":[7,20,46,86,89,97,166],"five":[8],"plasma":[9],"proteins:":[10],"CFHR1,":[11],"CFHR2,":[12],"CFHR3,":[13],"CFHR4":[14],"and":[15,17,63,73,104,157,172],"CFHR5,":[16],"each":[18,98],"member":[19],"this":[21],"binds":[23],"to":[24,84,108,161],"the":[25,37,87,90,94,105,129,151,164],"central":[26],"complement":[27,79,102,170,174],"component":[28],"C3b.":[29],"Mutations,":[30],"genetic":[31],"deletions,":[32],"duplications":[33],"or":[34,141],"rearrangements":[35],"in":[36,101,135,159,169,173],"individual":[38],"CFHR":[39,91,99,118,130,155,167],"genes":[40,156],"are":[41],"associated":[42,175],"with":[43,138],"number":[45],"diseases":[47],"including":[48],"atypical":[49],"hemolytic":[50],"uremic":[51],"syndrome":[52],"(aHUS),":[53],"C3":[54],"glomerulopathies":[55],"(C3":[56],"glomerulonephritis":[57],"(C3GN),":[58],"dense":[59],"deposit":[60],"disease":[61,109],"(DDD)":[62],"CFHR5":[64],"nephropathy),":[65],"IgA":[66],"nephropathy,":[67],"age":[68],"macular":[70],"degeneration":[71],"(AMD)":[72],"systemic":[74],"lupus":[75],"erythematosus":[76],"(SLE).":[77],"Although":[78],"regulatory":[80],"functions":[81],"were":[82],"attributed":[83],"most":[85],"members":[88],"protein":[92,100],"family,":[93],"precise":[95],"role":[96,165],"activation":[103,171],"exact":[106],"contribution":[107],"pathology":[110],"is":[111],"still":[112],"unclear.":[113],"Recent":[114],"publications":[115],"show":[116],"that":[117],"form":[120],"homo-":[121],"as":[122,124],"well":[123],"heterodimers.":[125],"Genetic":[126],"abnormalities":[127],"within":[128],"gene":[131],"locus":[132],"can":[133],"result":[134],"hybrid":[136],"affected":[139],"dimerization":[140],"recognition":[142],"domains":[143],"which":[144],"cause":[145],"defective":[146],"functions.":[147],"Here":[148],"we":[149],"summarize":[150],"recent":[152],"data":[153],"about":[154],"order":[160],"better":[162],"understand":[163],"diseases.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}