{"id":"https://openalex.org/W2082854150","doi":"https://doi.org/10.1073/pnas.92.12.5645","title":"Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.","display_name":"Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.","publication_year":1995,"publication_date":"1995-06-06","ids":{"openalex":"https://openalex.org/W2082854150","doi":"https://doi.org/10.1073/pnas.92.12.5645","mag":"2082854150","pmid":"https://pubmed.ncbi.nlm.nih.gov/7539922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/41753"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.92.12.5645","doi":"https://doi.org/10.1073/pnas.92.12.5645","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.12.5645","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/41753","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086175740","display_name":"Hans A.R. Bluyssen","orcid":"https://orcid.org/0000-0002-4568-6259","observed_orcids":["https://orcid.org/0000-0002-4568-6259"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H A Bluyssen","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072015747","display_name":"Rana Muzaffar","orcid":"https://orcid.org/0000-0001-8022-479X","observed_orcids":["https://orcid.org/0000-0001-8022-479X"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Muzaffar","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088877917","display_name":"R J Vlieststra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Vlieststra","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112209481","display_name":"Angelique C. van der Made","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A C van der Made","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110273608","display_name":"Stewart Leung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Leung","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA","Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080998429","display_name":"George Robert Stark","orcid":"https://orcid.org/0000-0002-8776-9597","observed_orcids":["https://orcid.org/0000-0002-8776-9597"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G R Stark","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA","Case Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Case Comprehensive Cancer Center","institution_ids":["https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029776635","display_name":"Ian Macpherson Kerr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"I M Kerr","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA","Cancer Research UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Cancer Research UK","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026981971","display_name":"Jan Trapman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Trapman","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068788861","display_name":"David E. Levy","orcid":"https://orcid.org/0000-0002-7320-7788","observed_orcids":["https://orcid.org/0000-0002-7320-7788"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D E Levy","raw_affiliation_strings":["Department of Pathology, New York University School of Medicine, New York 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University School of Medicine, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5323,"has_fulltext":false,"cited_by_count":142,"citation_normalized_percentile":{"value":0.96615695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"92","issue":"12","first_page":"5645","last_page":"5649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isgf3","display_name":"ISGF3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interferon-stimulated-response-element","display_name":"interferon-stimulated response element","score":0.9480000138282776},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.734000027179718},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8859999775886536},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.5329999923706055},{"id":"https://openalex.org/keywords/stat2","display_name":"STAT2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/p48","display_name":"p48","score":0.7139999866485596},{"id":"https://openalex.org/keywords/transcription-factor-complex","display_name":"transcription factor complex","score":0.5450000166893005},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/fibrosarcoma-cells","display_name":"fibrosarcoma cells","score":0.6100000143051147},{"id":"https://openalex.org/keywords/mutant-cell-lines","display_name":"mutant cell lines","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2776239193","wikidata":"https://www.wikidata.org/wiki/Q18031750","display_name":"STAT2","level":5,"score":0.8711613416671753},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.6452493667602539},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6361798644065857},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.6172808408737183},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6061915755271912},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5787243843078613},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.5651136040687561},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5039212107658386},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.4710288643836975},{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.44030898809432983},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4350174367427826},{"id":"https://openalex.org/C32300475","wikidata":"https://www.wikidata.org/wiki/Q18027992","display_name":"IRF1","level":4,"score":0.41707903146743774},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.31317031383514404},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2899670898914337},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27812641859054565},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23999792337417603},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21810954809188843},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1983659267425537},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.18779391050338745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1599809229373932},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10674387216567993},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050795","descriptor_name":"STAT2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050832","descriptor_name":"Interferon-Stimulated Gene Factor 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050834","descriptor_name":"Interferon-Stimulated Gene Factor 3, gamma Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.92.12.5645","doi":"https://doi.org/10.1073/pnas.92.12.5645","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.12.5645","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:41753","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/41753","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:7539922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7539922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:41753","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/41753","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8750518131","display_name":"ISGF3 Transcription Factor Family in Cytokine Signaling","funder_award_id":"R01AI028900","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W98489723","https://openalex.org/W275894516","https://openalex.org/W318497777","https://openalex.org/W1510347472","https://openalex.org/W1521367633","https://openalex.org/W1847235528","https://openalex.org/W1851636512","https://openalex.org/W1866683333","https://openalex.org/W1954929088","https://openalex.org/W1965398762","https://openalex.org/W1966312399","https://openalex.org/W1970023609","https://openalex.org/W1983630074","https://openalex.org/W1986021037","https://openalex.org/W1989897445","https://openalex.org/W1990931418","https://openalex.org/W1993292631","https://openalex.org/W1996909138","https://openalex.org/W1997935194","https://openalex.org/W2012438019","https://openalex.org/W2037968180","https://openalex.org/W2038459819","https://openalex.org/W2041187882","https://openalex.org/W2043006415","https://openalex.org/W2043803403","https://openalex.org/W2044296969","https://openalex.org/W2060333964","https://openalex.org/W2067626539","https://openalex.org/W2068145756","https://openalex.org/W2074664341","https://openalex.org/W2093874299","https://openalex.org/W2109389988","https://openalex.org/W2122312331","https://openalex.org/W2136690547","https://openalex.org/W2144206181","https://openalex.org/W2149563853","https://openalex.org/W2150409982","https://openalex.org/W2151712105","https://openalex.org/W2153987432","https://openalex.org/W2161239928","https://openalex.org/W2282986747"],"related_works":["https://openalex.org/W1982238582","https://openalex.org/W2036369869","https://openalex.org/W318497777","https://openalex.org/W98489723","https://openalex.org/W2136690547","https://openalex.org/W2092412217","https://openalex.org/W4381598641","https://openalex.org/W1516222795","https://openalex.org/W2022167790","https://openalex.org/W2282986747"],"abstract_inverted_index":{"Genes":[0],"containing":[1,170],"the":[2,73,89,100,106,116,129,179,202],"interferon-stimulated":[3,31],"response":[4,69,103,124],"element":[5],"(ISRE)":[6],"enhancer":[7],"have":[8],"been":[9],"characterized":[10],"as":[11,57,59,112,114],"transcriptionally":[12],"responsive":[13],"primarily":[14],"to":[15,24,82,125,136,151,205],"type":[16],"I":[17],"interferons":[18],"(IFN":[19],"alpha/beta).":[20],"Induction":[21],"is":[22,37],"due":[23],"activation":[25,185],"of":[26,80,91,95,147,157,186,194,201],"a":[27,85],"multimeric":[28],"transcription":[29],"factor,":[30],"gene":[32],"factor":[33],"3":[34],"(ISGF3),":[35],"which":[36],"activated":[38],"by":[39,44,54,60,78],"IFN":[40,45,55,61,67,83,101,126,154,183,206,209],"alpha/beta":[41],"but":[42,165,175],"not":[43,166],"gamma.":[46,210],"We":[47],"found":[48],"that":[49,87,99,153],"ISRE-containing":[50],"genes":[51],"were":[52,149],"induced":[53],"gamma":[56,68,102,110,155],"well":[58,113],"alpha":[62,127,207],"in":[63,134,144,181],"Vero":[64],"cells.":[65],"The":[66,122],"was":[70,76],"dependent":[71],"on":[72,105,115],"ISRE":[74,159,180],"and":[75,138,163,172,196,208],"accentuated":[77],"preexposure":[79],"cells":[81,142],"alpha,":[84],"treatment":[86],"increases":[88],"abundance":[90],"ISGF3":[92,96,109,148],"components.":[93],"Overexpression":[94],"polypeptides":[97],"showed":[98],"depended":[104],"DNA-binding":[107],"protein":[108,118,131],"(p48)":[111],"91-kDa":[117],"STAT91":[119,137,174],"(Stat1":[120],"alpha).":[121],"transcriptional":[123],"required":[128,161],"113-kDa":[130],"STAT113":[132,177],"(Stat2)":[133],"addition":[135],"p48.":[139],"Mutant":[140],"fibrosarcoma":[141],"deficient":[143],"each":[145],"component":[146],"used":[150],"confirm":[152],"induction":[156],"an":[158],"reporter":[160],"p48":[162,171,195],"STAT91,":[164,197],"STAT113.":[167],"A":[168],"complex":[169],"phosphorylated":[173],"lacking":[176],"bound":[178],"vitro.":[182],"gamma-induced":[184],"this":[187],"complex,":[188],"preferentially":[189],"formed":[190],"at":[191],"high":[192],"concentrations":[193],"may":[198],"explain":[199],"some":[200],"overlapping":[203],"responses":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
