{"id":"https://openalex.org/W2082852371","doi":"https://doi.org/10.3109/15569528409036279","title":"Dermal Sensitizing Potential of Glutaraldehyde: A Review and Recent Observations","display_name":"Dermal Sensitizing Potential of Glutaraldehyde: A Review and Recent Observations","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2082852371","doi":"https://doi.org/10.3109/15569528409036279","mag":"2082852371"},"language":"en","primary_location":{"id":"doi:10.3109/15569528409036279","doi":"https://doi.org/10.3109/15569528409036279","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15569528409036279","pdf_url":null,"source":{"id":"https://openalex.org/S29939878","display_name":"Journal of Toxicology Cutaneous and Ocular Toxicology","issn_l":"0731-3829","issn":["0731-3829","1532-2505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology: Cutaneous and Ocular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029612246","display_name":"Bryan Ballantyne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891856","display_name":"Union Carbide (United States)","ror":"https://ror.org/04hj96d73","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143","https://openalex.org/I4388891856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Ballantyne","raw_affiliation_strings":["Union Carbide Corporation, Danbury, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Carbide Corporation, Danbury, Connecticut","institution_ids":["https://openalex.org/I4388891856"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037610321","display_name":"Brian Berman","orcid":"https://orcid.org/0000-0001-9872-5402","observed_orcids":["https://orcid.org/0000-0001-9872-5402"]},"institutions":[{"id":"https://openalex.org/I4210162323","display_name":"TKL Research","ror":"https://ror.org/059gb3r46","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210162323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Berman","raw_affiliation_strings":["TKL Research, Inc., New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TKL Research, Inc., New York, New York","institution_ids":["https://openalex.org/I4210162323"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5987,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.67169179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"3","first_page":"251","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutaraldehyde","display_name":"glutaraldehyde","score":1.0},{"id":"https://openalex.org/keywords/allergic-contact-dermatitis","display_name":"allergic contact dermatitis","score":0.906000018119812},{"id":"https://openalex.org/keywords/skin-sensitization","display_name":"skin sensitization","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.9876209497451782},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.8326770663261414},{"id":"https://openalex.org/C2776056826","wikidata":"https://www.wikidata.org/wiki/Q16242752","display_name":"Allergic contact dermatitis","level":3,"score":0.4727552533149719},{"id":"https://openalex.org/C3018346242","wikidata":"https://www.wikidata.org/wiki/Q4826986","display_name":"Skin sensitization","level":3,"score":0.4527492821216583},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.42075416445732117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39940139651298523},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3223803639411926},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24257799983024597},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.20229479670524597},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17558062076568604}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3109/15569528409036279","doi":"https://doi.org/10.3109/15569528409036279","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15569528409036279","pdf_url":null,"source":{"id":"https://openalex.org/S29939878","display_name":"Journal of Toxicology Cutaneous and Ocular Toxicology","issn_l":"0731-3829","issn":["0731-3829","1532-2505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology: Cutaneous and Ocular Toxicology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1487755519","https://openalex.org/W1495887818","https://openalex.org/W1528569546","https://openalex.org/W1596427724","https://openalex.org/W1596880830","https://openalex.org/W1984553877","https://openalex.org/W1985379181","https://openalex.org/W1987453351","https://openalex.org/W1987502117","https://openalex.org/W1989723491","https://openalex.org/W1996212450","https://openalex.org/W1999930012","https://openalex.org/W2017429901","https://openalex.org/W2026948567","https://openalex.org/W2035202893","https://openalex.org/W2038681076","https://openalex.org/W2045119965","https://openalex.org/W2047706313","https://openalex.org/W2055820224","https://openalex.org/W2063423258","https://openalex.org/W2077277661","https://openalex.org/W2085378328","https://openalex.org/W2208170456","https://openalex.org/W2403208657","https://openalex.org/W4232222270","https://openalex.org/W4242289861"],"related_works":["https://openalex.org/W1999930012","https://openalex.org/W2313809629","https://openalex.org/W4245979512","https://openalex.org/W2319203444","https://openalex.org/W2097770973","https://openalex.org/W1984907424","https://openalex.org/W2035202893","https://openalex.org/W2417622733","https://openalex.org/W1995449980","https://openalex.org/W3214902946"],"abstract_inverted_index":{"Isolated":[0],"case":[1,63],"reports":[2,16,49],"indicate":[3],"a":[4,27],"potential":[5],"for":[6,80,111],"glutaraldehyde":[7,25,46,54,81,115],"to":[8,18,32,45,55,85,94],"cause":[9],"allergic":[10],"contact":[11],"dermatitis.":[12],"The":[13],"number":[14],"of":[15,24,30,43,53,62,66,99],"relative":[17],"the":[19,33,39,51,67,72,77,91,107],"widespread":[20],"and":[21,65],"diverse":[22],"usage":[23],"suggest":[26,75],"low":[28],"incidence":[29],"sensitization":[31,44,88,113],"material.":[34],"This":[35],"is":[36,89,118],"confirmed":[37],"by":[38,114],"comparatively":[40],"few":[41],"cases":[42],"described":[47,102],"in":[48,82,90,103,116],"documenting":[50],"use":[52],"treat":[56],"various":[57],"dermatological":[58],"disorders.":[59],"A":[60],"review":[61],"reports,":[64],"limited":[68],"definitive":[69],"investigations":[70],"into":[71],"sensitizing":[73],"potential,":[74],"that":[76],"threshold":[78,109],"concentration":[79,110],"aqueous":[83],"solution":[84],"induce":[86],"dermal":[87,112],"range":[92],"0.1%":[93],"1.0%.":[95],"Recently":[96],"conducted":[97],"studies":[98],"human":[100],"volunteers,":[101],"this":[104],"paper,":[105],"show":[106],"eliciting":[108],"water":[117],"0.5%.":[119]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}