{"id":"https://openalex.org/W2082814916","doi":"https://doi.org/10.1210/jcem-63-2-510","title":"Progressive Decrease in Serum Sex Hormone-Binding Globulin from Infancy to Late Prepuberty in Boys","display_name":"Progressive Decrease in Serum Sex Hormone-Binding Globulin from Infancy to Late Prepuberty in Boys","publication_year":1986,"publication_date":"1986-08-01","ids":{"openalex":"https://openalex.org/W2082814916","doi":"https://doi.org/10.1210/jcem-63-2-510","mag":"2082814916","pmid":"https://pubmed.ncbi.nlm.nih.gov/3722336"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-63-2-510","doi":"https://doi.org/10.1210/jcem-63-2-510","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-63-2-510","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076870787","display_name":"Alicia Belgorosky","orcid":"https://orcid.org/0000-0002-4234-400X","observed_orcids":["https://orcid.org/0000-0002-4234-400X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALICIA BELGOROSKY","raw_affiliation_strings":["Centra de Investigaciones Endocrinologicas, Hospital de Ni\u00f1os, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centra de Investigaciones Endocrinologicas, Hospital de Ni\u00f1os, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111986328","display_name":"Marco Aurelio Rivarola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARCO A. RIVAROLA","raw_affiliation_strings":["Centra de Investigaciones Endocrinologicas, Hospital de Ni\u00f1os, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centra de Investigaciones Endocrinologicas, Hospital de Ni\u00f1os, Buenos Aires, Argentina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.0877,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.85011118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"63","issue":"2","first_page":"510","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.8353999853134155,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.8353999853134155,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.11659999936819077,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":1.0},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.7960000038146973},{"id":"https://openalex.org/keywords/affinity-constant","display_name":"affinity constant","score":0.7910000085830688},{"id":"https://openalex.org/keywords/puberty-onset","display_name":"puberty onset","score":0.5870000123977661},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.7649999856948853},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.9750000238418579},{"id":"https://openalex.org/keywords/prepubertal-boys","display_name":"prepubertal boys","score":0.6930000185966492},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.9621067643165588},{"id":"https://openalex.org/C2910820727","wikidata":"https://www.wikidata.org/wiki/Q719723","display_name":"Prepuberty","level":3,"score":0.8904348611831665},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8830699920654297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8713047504425049},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6503481864929199},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6384254693984985},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.5945059657096863},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.5784626007080078},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5659173130989075},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5011990070343018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3760821223258972},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26365160942077637}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-63-2-510","doi":"https://doi.org/10.1210/jcem-63-2-510","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-63-2-510","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:3722336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3722336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322821","display_name":"Kementerian Pendidikan Nasional","ror":"https://ror.org/03sxt1c89"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1973474055","https://openalex.org/W1995993817","https://openalex.org/W2002417420","https://openalex.org/W2032229603","https://openalex.org/W2034020855","https://openalex.org/W2040140075","https://openalex.org/W2049712837","https://openalex.org/W2054872702","https://openalex.org/W2080308968","https://openalex.org/W2133753630","https://openalex.org/W2162024124","https://openalex.org/W2266899839","https://openalex.org/W2304146752"],"related_works":["https://openalex.org/W2087866579","https://openalex.org/W2047547946","https://openalex.org/W1979135403","https://openalex.org/W2040376712","https://openalex.org/W1969569818","https://openalex.org/W1999182830","https://openalex.org/W2331955541","https://openalex.org/W7217065530","https://openalex.org/W2412132904","https://openalex.org/W1977701494"],"abstract_inverted_index":{"Serum":[0],"Sex":[1],"hormone-binding":[2],"globulin":[3],"(SHBG)":[4],"levels":[5],"and":[6,101],"affinity":[7],"constant":[8],"(Ka)":[9],"of":[10,29,41,47,82,86,104,113,120],"SHBG-dihydrotestosterone":[11],"association":[12],"were":[13,57],"determined":[14],"in":[15,35,45,76,116],"91":[16],"boys,":[17],"aged":[18],"3":[19],"months":[20],"to":[21,64],"15":[22],"yr,":[23],"all":[24],"at":[25,54],"Tanner":[26],"stage":[27],"I":[28],"pubertal":[30],"development.":[31],"A":[32],"gradual":[33],"decrease":[34,75],"serum":[36,49],"SHBG":[37,65,77],"as":[38],"a":[39,74],"function":[40],"age":[42],"was":[43],"found":[44],"spite":[46],"unchanged":[48,91],"testosterone":[50],"levels.":[51],"Ka":[52],"values":[53],"different":[55],"ages":[56],"not":[58,67],"significantly":[59],"different.":[60],"Since":[61],"steroids":[62],"bound":[63],"are":[66],"transported":[68],"into":[69],"most":[70],"tissues,":[71],"particularly":[72],"brain,":[73],"will":[78],"have":[79],"the":[80,97,105,118],"effect":[81],"increasing":[83,99],"tissue":[84],"entrance":[85],"non-SHBG-bound":[87],"sex":[88],"hormones":[89],"despite":[90],"plasma":[92],"concentrations.":[93],"We":[94],"speculate":[95],"that":[96],"gradually":[98],"androgen":[100],"estrogen":[102],"milieu":[103],"brain":[106],"created":[107],"by":[108],"this":[109],"mechanism":[110],"might":[111],"be":[112],"physiological":[114],"significance":[115],"triggering":[117],"onset":[119],"puberty.":[121]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
