{"id":"https://openalex.org/W2082728129","doi":"https://doi.org/10.3892/ijo.9.2.247","title":"Expression of prothymosin-alpha and c-myc mRNA in human gastric cancer","display_name":"Expression of prothymosin-alpha and c-myc mRNA in human gastric cancer","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2082728129","doi":"https://doi.org/10.3892/ijo.9.2.247","mag":"2082728129","pmid":"https://pubmed.ncbi.nlm.nih.gov/21541507"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.9.2.247","doi":"https://doi.org/10.3892/ijo.9.2.247","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.9.2.247","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008074283","display_name":"Kenji Shibuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Shibuta","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009475999","display_name":"Mikito Mori","orcid":"https://orcid.org/0000-0001-8946-3471","observed_orcids":["https://orcid.org/0000-0001-8946-3471"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Mori","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017606167","display_name":"Koshi Mimori","orcid":"https://orcid.org/0000-0003-3897-9974","observed_orcids":["https://orcid.org/0000-0003-3897-9974"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Mimori","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006787725","display_name":"Hiroshi Inoue","orcid":"https://orcid.org/0000-0002-7724-6637","observed_orcids":["https://orcid.org/0000-0002-7724-6637"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Inoue","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054093764","display_name":"Hiroshi Nakashima","orcid":"https://orcid.org/0000-0001-9678-9234","observed_orcids":["https://orcid.org/0000-0001-9678-9234"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Nakashima","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112131981","display_name":"K. Baba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Baba","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Haraguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Haraguchi","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040261539","display_name":"Nobuya Karimine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Karimine","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027854342","display_name":"Hiroaki Ueo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Ueo","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012769131","display_name":"Takashi Akiyoshi","orcid":"https://orcid.org/0000-0002-2321-1412","observed_orcids":["https://orcid.org/0000-0002-2321-1412"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Akiyoshi","raw_affiliation_strings":["KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":null,"apc_paid":null,"fwci":0.4174,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.6814036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"9","issue":"2","first_page":"247","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prothymosin-alpha","display_name":"prothymosin alpha","score":0.9959999918937683},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.9380000233650208},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7795923352241516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6938261985778809},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.658694326877594},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6337689161300659},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5730198621749878},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5638163685798645},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5357934832572937},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5281800031661987},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5133072733879089},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5025608539581299},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.5015699863433838},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44570058584213257},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.4307994544506073},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4237176477909088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10816076397895813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09931772947311401},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3892/ijo.9.2.247","doi":"https://doi.org/10.3892/ijo.9.2.247","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.9.2.247","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:21541507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21541507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2290052486","https://openalex.org/W1968967813","https://openalex.org/W2367900632","https://openalex.org/W2046618959","https://openalex.org/W2005608115","https://openalex.org/W2053280007","https://openalex.org/W2036043215","https://openalex.org/W1987762716","https://openalex.org/W2980178073","https://openalex.org/W2972840929"],"abstract_inverted_index":{"Prothymosin-alpha":[0],"(PT-alpha)":[1],"is":[2,11,23,163],"a":[3,93,137],"nuclear":[4],"protein":[5],"involved":[6],"in":[7,13,32,46,58,102],"cell":[8],"proliferation.":[9],"c-myc":[10,30,43,55,171],"implicated":[12],"the":[14,29,40,52,72,129,143,152,159,168,174],"carcinogenesis":[15],"of":[16,61,80,96,121,128,145,161,170,176],"many":[17],"human":[18,156],"cancers.":[19],"PT-alpha":[20,41,53,86,110,162],"gene":[21,31,178],"transcription":[22,160],"reported":[24,38],"to":[25,165],"be":[26,166],"regulated":[27],"by":[28],"vitro.":[33],"However,":[34,136],"little":[35],"has":[36],"been":[37],"on":[39],"and":[42,54,66,87,105,111,126],"mRNA":[44,56,124],"expressions":[45,57,125,144,179],"gastric":[47,62,134,157],"cancer.":[48,135],"We":[49],"semi-quantitatively":[50],"determined":[51],"60":[59],"pairs":[60],"cancer":[63],"tissue":[64,69],"(T)":[65],"corresponding":[67],"normal":[68],"(N)":[70],"using":[71],"reverse":[73],"transcriptase-polymerase":[74],"chain":[75],"reaction":[76],"method.":[77],"The":[78,149],"average":[79],"T/N":[81,94],"ratio":[82,95],"was":[83,117,140],"1.20":[84],"for":[85,89,109,133],"1.30":[88],"c-myc.":[90],"Cases":[91],"demonstrating":[92],"more":[97],"than":[98],"1.0":[99],"were":[100],"seen":[101,141],"33":[103],"(55%)":[104],"30":[106],"(50%)":[107],"cases":[108],"c-myc,":[112],"respectively.":[113],"No":[114],"significant":[115,138],"correlation":[116,139],"observed":[118],"between":[119,142],"either":[120],"these":[122,177],"two":[123],"any":[127],"examined":[130],"clinicopathologic":[131],"factors":[132],"both":[146],"genes":[147],"(p<0.0001).":[148],"findings":[150],"support":[151],"hypothesis":[153],"that,":[154],"regarding":[155],"cancer,":[158],"considered":[164],"under":[167],"control":[169],"gene,":[172],"however,":[173],"value":[175],"do":[180],"not":[181],"reflect":[182],"biological":[183],"behavior.":[184]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}