{"id":"https://openalex.org/W2082678679","doi":"https://doi.org/10.1073/pnas.83.11.3929","title":"Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.","display_name":"Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.","publication_year":1986,"publication_date":"1986-06-01","ids":{"openalex":"https://openalex.org/W2082678679","doi":"https://doi.org/10.1073/pnas.83.11.3929","mag":"2082678679","pmid":"https://pubmed.ncbi.nlm.nih.gov/3459164","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/323638"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.83.11.3929","doi":"https://doi.org/10.1073/pnas.83.11.3929","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.83.11.3929","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/323638","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024741961","display_name":"Aldons Jake Lusis","orcid":"https://orcid.org/0000-0001-9013-0228","observed_orcids":["https://orcid.org/0000-0001-9013-0228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Lusis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061856907","display_name":"Camilla Heinzmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Heinzmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013170481","display_name":"R S Sparkes","orcid":"https://orcid.org/0000-0003-2930-940X","observed_orcids":["https://orcid.org/0000-0003-2930-940X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R S Sparkes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063167193","display_name":"James Scott","orcid":"https://orcid.org/0000-0002-0744-0688","observed_orcids":["https://orcid.org/0000-0002-0744-0688"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110017133","display_name":"Timothy J. Knott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Knott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024366450","display_name":"Robin L. Geller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Geller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109089847","display_name":"M.C. Sparkes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Sparkes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040652402","display_name":"Thuluvancheri K. Mohandas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Mohandas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.7703,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.99147753,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"83","issue":"11","first_page":"3929","last_page":"3933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.2957000136375427,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.2957000136375427,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.27219998836517334,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-chromosome-19","display_name":"chromosome 19","score":0.8730000257492065},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.7889999747276306},{"id":"https://openalex.org/keywords/apoc1","display_name":"APOC1","score":0.7630000114440918},{"id":"https://openalex.org/keywords/apolipoprotein-c2","display_name":"apolipoprotein C2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":1.0},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9430000185966492},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7099999785423279},{"id":"https://openalex.org/keywords/glucose-6-phosphate-isomerase","display_name":"phosphoglucose isomerase","score":0.984000027179718},{"id":"https://openalex.org/keywords/reciprocal-translocation","display_name":"reciprocal translocation","score":0.675000011920929},{"id":"https://openalex.org/keywords/somatic-hybrids","display_name":"somatic cell hybrids","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tandem-gene-arrangement","display_name":"tandem gene arrangement","score":0.6320000290870667},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6595248579978943},{"id":"https://openalex.org/C130693829","wikidata":"https://www.wikidata.org/wiki/Q510786","display_name":"Chromosome 19","level":4,"score":0.5764946937561035},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.569247305393219},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5558074712753296},{"id":"https://openalex.org/C56623246","wikidata":"https://www.wikidata.org/wiki/Q14916272","display_name":"Apolipoprotein C2","level":5,"score":0.4717458188533783},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.4424746334552765},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.4324226379394531},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.41035518050193787},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4081410765647888},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3271709978580475},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2658756375312805},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.11482581496238708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1044878363609314},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.052569448947906494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05060243606567383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001056","descriptor_name":"Apolipoproteins C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002903","descriptor_name":"Chromosomes, Human, 19-20","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004150","descriptor_name":"Dipeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005956","descriptor_name":"Glucose-6-Phosphate Isomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053302","descriptor_name":"Apolipoprotein C-I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053304","descriptor_name":"Apolipoprotein C-II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.83.11.3929","doi":"https://doi.org/10.1073/pnas.83.11.3929","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.83.11.3929","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:323638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/323638","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3459164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3459164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:323638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/323638","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1566658517","display_name":"HUMAN X CHROMOSOMES IN TERATOCARCINOMA CELLS","funder_award_id":"F32HD006561","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G730134193","display_name":null,"funder_award_id":"HL 27-481","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1499715854","https://openalex.org/W1522648964","https://openalex.org/W1564703693","https://openalex.org/W1920171370","https://openalex.org/W1964986765","https://openalex.org/W1966008200","https://openalex.org/W1970127048","https://openalex.org/W1971057631","https://openalex.org/W1972388049","https://openalex.org/W1975860714","https://openalex.org/W1975889556","https://openalex.org/W1979093625","https://openalex.org/W1980092242","https://openalex.org/W1984097098","https://openalex.org/W1990815703","https://openalex.org/W2007215900","https://openalex.org/W2009460561","https://openalex.org/W2010542513","https://openalex.org/W2012134426","https://openalex.org/W2014345761","https://openalex.org/W2014669590","https://openalex.org/W2018499950","https://openalex.org/W2023810291","https://openalex.org/W2025256012","https://openalex.org/W2026674552","https://openalex.org/W2028518930","https://openalex.org/W2029987769","https://openalex.org/W2032069849","https://openalex.org/W2045001630","https://openalex.org/W2046516243","https://openalex.org/W2049251238","https://openalex.org/W2054684040","https://openalex.org/W2054884509","https://openalex.org/W2057699621","https://openalex.org/W2059089113","https://openalex.org/W2059635505","https://openalex.org/W2060024791","https://openalex.org/W2063450941","https://openalex.org/W2064683627","https://openalex.org/W2077219082","https://openalex.org/W2077546371","https://openalex.org/W2084037767","https://openalex.org/W2087737282","https://openalex.org/W2089494415","https://openalex.org/W2093007157","https://openalex.org/W2095488937","https://openalex.org/W2107312689","https://openalex.org/W2155495539","https://openalex.org/W2410735034","https://openalex.org/W4298767819"],"related_works":["https://openalex.org/W2079116104","https://openalex.org/W2086495464","https://openalex.org/W2026326270","https://openalex.org/W2011820698","https://openalex.org/W1970127048","https://openalex.org/W1975889556","https://openalex.org/W2000624589","https://openalex.org/W2323892235","https://openalex.org/W2157747788","https://openalex.org/W2049251238"],"abstract_inverted_index":{"We":[0],"report":[1],"the":[2,32,40,47,61,66,74,93,99,115,127,178,190,197],"regional":[3,26],"mapping":[4,27],"of":[5,34,43,50,54,69,150,164,174,193,199],"human":[6],"chromosome":[7,44,51,70,194],"19":[8,45,71],"genes":[9,20,75,97,153,180],"for":[10,21,76,98],"three":[11,22,55],"apolipoproteins":[12,77],"and":[13,46,80,84,87,109,148,157,176,183],"a":[14,35,141,186],"lipoprotein":[15,102],"receptor":[16,103],"as":[17,19],"well":[18],"other":[23],"markers.":[24],"The":[25],"was":[28],"made":[29],"possible":[30],"by":[31,160],"use":[33],"reciprocal":[36],"whole-arm":[37],"translocation":[38],"between":[39],"long":[41,62,94,191],"arm":[42,49,63,68,192],"short":[48,67,116],"1.":[52],"Examination":[53],"separate":[56],"somatic":[57],"cell":[58],"hybrids":[59],"containing":[60],"but":[64],"not":[65],"indicated":[72],"that":[73],"CI,":[78],"CII,":[79],"E":[81],"(APOC1,":[82],"APOC2,":[83,134,177,182],"APOE,":[85],"respectively)":[86],"glucose-6-phosphate":[88],"isomerase":[89],"(GPI)":[90],"reside":[91,113],"on":[92,114,189],"arm,":[95],"whereas":[96],"low":[100],"density":[101],"(LDLR),":[104],"complement":[105],"component":[106],"3":[107],"(C3),":[108],"peptidase":[110],"D":[111],"(PEPD)":[112],"arm.":[117],"When":[118],"taken":[119],"together":[120],"with":[121],"previous":[122,168],"studies,":[123],"our":[124],"results":[125],"suggest":[126],"following":[128],"physical":[129],"gene":[130],"map:":[131],"pter-LDLR-C3-p13.2-PEPD-centromere-(APOE,":[132],"APOC1,":[133,181],"GPI)-qter.":[135],"In":[136],"addition,":[137],"we":[138],"have":[139],"isolated":[140],"single":[142],"lambda":[143],"phage":[144],"carrying":[145],"both":[146],"APOC1":[147],"part":[149],"APOE.":[151],"These":[152],"are":[154,158],"tandemly":[155],"oriented":[156],"separated":[159],"about":[161],"6":[162],"kilobases":[163],"genomic":[165],"DNA.":[166],"Since":[167],"family":[169],"studies":[170],"indicate":[171],"tight":[172,187],"linkage":[173],"APOE":[175,184],"apolipoprotein":[179],"form":[185],"complex":[188],"19,":[195],"suggesting":[196],"possibility":[198],"coordinate":[200],"regulation.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
