{"id":"https://openalex.org/W2082633147","doi":"https://doi.org/10.1007/s00044-014-1102-1","title":"Synthesis, bioassay studies, and molecular docking of novel 5-substituted 1H tetrazoles as cyclooxygenase-2 (COX-2) inhibitors","display_name":"Synthesis, bioassay studies, and molecular docking of novel 5-substituted 1H tetrazoles as cyclooxygenase-2 (COX-2) inhibitors","publication_year":2014,"publication_date":"2014-07-02","ids":{"openalex":"https://openalex.org/W2082633147","doi":"https://doi.org/10.1007/s00044-014-1102-1","mag":"2082633147"},"language":"en","primary_location":{"id":"doi:10.1007/s00044-014-1102-1","doi":"https://doi.org/10.1007/s00044-014-1102-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00044-014-1102-1","pdf_url":null,"source":{"id":"https://openalex.org/S36909932","display_name":"Medicinal Chemistry Research","issn_l":"1054-2523","issn":["1054-2523","1554-8120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104305103","display_name":"Baker Jawabrah Al\u2010Hourani","orcid":"https://orcid.org/0000-0002-9548-4639","observed_orcids":["https://orcid.org/0000-0002-9548-4639"]},"institutions":[{"id":"https://openalex.org/I161387315","display_name":"American University of Madaba","ror":"https://ror.org/04tgeej53","country_code":"JO","type":"education","lineage":["https://openalex.org/I161387315"]}],"countries":["JO"],"is_corresponding":true,"raw_author_name":"Baker Jawabrah Al-Hourani","raw_affiliation_strings":["Department of Basic Sciences and Humanities, American University of Madaba, P.O. Box 2882, Amman, 11821, Jordan","American University of Madaba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences and Humanities, American University of Madaba, P.O. Box 2882, Amman, 11821, Jordan","institution_ids":["https://openalex.org/I161387315"]},{"raw_affiliation_string":"American University of Madaba","institution_ids":["https://openalex.org/I161387315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034390741","display_name":"Sai Kiran Sharma","orcid":"https://orcid.org/0000-0002-8199-7601","observed_orcids":["https://orcid.org/0000-0002-8199-7601"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sai Kiran Sharma","raw_affiliation_strings":["Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada","University of Alberta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"University of Alberta","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018891381","display_name":"Jatinder Paul Kaur","orcid":"https://orcid.org/0000-0001-6565-7909","observed_orcids":["https://orcid.org/0000-0001-6565-7909"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jatinder Kaur","raw_affiliation_strings":["Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada","University of Alberta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"University of Alberta","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081387229","display_name":"Frank R. Wuest","orcid":"https://orcid.org/0000-0002-6705-6450","observed_orcids":["https://orcid.org/0000-0002-6705-6450"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Frank Wuest","raw_affiliation_strings":["Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada","University of Alberta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"University of Alberta","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104305103"],"corresponding_institution_ids":["https://openalex.org/I161387315"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":1.0853,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72210009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"24","issue":"1","first_page":"78","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13265","display_name":"Synthesis of Tetrazole Derivatives","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13265","display_name":"Synthesis of Tetrazole Derivatives","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1h-tetrazoles","display_name":"1H-tetrazoles","score":0.9070000052452087},{"id":"https://openalex.org/keywords/5-substituted-1h-tetrazoles","display_name":"5-substituted tetrazoles","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cox-2-selectivity","display_name":"COX-2 selectivity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cox-1-inhibition","display_name":"COX-1 inhibition","score":0.8370000123977661},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7289999723434448},{"id":"https://openalex.org/keywords/anti-inflammatory-drug-design","display_name":"anti-inflammatory drug design","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8610266447067261},{"id":"https://openalex.org/C2780827033","wikidata":"https://www.wikidata.org/wiki/Q58826308","display_name":"Tetrazole","level":2,"score":0.8341087102890015},{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.8298503756523132},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.694312572479248},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.6392092704772949},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.6246924996376038},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5860335826873779},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.5722286701202393},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.501990795135498},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.48749637603759766},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.47474294900894165},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.42416948080062866},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33119940757751465},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21497967839241028},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13583198189735413},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.09801921248435974},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00044-014-1102-1","doi":"https://doi.org/10.1007/s00044-014-1102-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00044-014-1102-1","pdf_url":null,"source":{"id":"https://openalex.org/S36909932","display_name":"Medicinal Chemistry Research","issn_l":"1054-2523","issn":["1054-2523","1554-8120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1480874656","https://openalex.org/W1964137480","https://openalex.org/W1971493095","https://openalex.org/W1978739653","https://openalex.org/W1979107796","https://openalex.org/W1980933092","https://openalex.org/W1989556851","https://openalex.org/W2010311152","https://openalex.org/W2010852340","https://openalex.org/W2017480892","https://openalex.org/W2030850720","https://openalex.org/W2033044862","https://openalex.org/W2033498682","https://openalex.org/W2066395665","https://openalex.org/W2070609164","https://openalex.org/W2077215912","https://openalex.org/W2077475587","https://openalex.org/W2078736915","https://openalex.org/W2110408266","https://openalex.org/W2131458350","https://openalex.org/W2151512266","https://openalex.org/W2159973565","https://openalex.org/W2325649581","https://openalex.org/W2346636973","https://openalex.org/W2951673084","https://openalex.org/W2953082822","https://openalex.org/W4239622936","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2151512266","https://openalex.org/W2077475587","https://openalex.org/W2518586256","https://openalex.org/W4224281481","https://openalex.org/W2017480892","https://openalex.org/W2953323407","https://openalex.org/W2949086749","https://openalex.org/W2026056700","https://openalex.org/W2029407509","https://openalex.org/W2184230432"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}