{"id":"https://openalex.org/W2082592497","doi":"https://doi.org/10.1046/j.1525-1381.1999.99223.x","title":"A Direct In Vivo Approach for Skin Gene Therapy","display_name":"A Direct In Vivo Approach for Skin Gene Therapy","publication_year":1999,"publication_date":"1999-05-09","ids":{"openalex":"https://openalex.org/W2082592497","doi":"https://doi.org/10.1046/j.1525-1381.1999.99223.x","mag":"2082592497","pmid":"https://pubmed.ncbi.nlm.nih.gov/10354358"},"language":"en","primary_location":{"id":"doi:10.1046/j.1525-1381.1999.99223.x","doi":"https://doi.org/10.1046/j.1525-1381.1999.99223.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1525-1381.1999.99223.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210222582","display_name":"Proceedings of the Association of American Physicians","issn_l":"1081-650X","issn":["1081-650X","1525-1381"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Association of American Physicians","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060729846","display_name":"Jonathan C. Vogel","orcid":"https://orcid.org/0000-0002-7102-0231","observed_orcids":["https://orcid.org/0000-0002-7102-0231"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan C. Vogel","raw_affiliation_strings":["Dermatology Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1908, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1908, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060729846"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":3.493,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.93369088,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"111","issue":"3","first_page":"190","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.2888000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vivo-gene-therapy","display_name":"in vivo gene therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/skin-gene-therapy","display_name":"skin gene therapy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/epidermal-gene-expression","display_name":"epidermal gene expression","score":0.9319999814033508},{"id":"https://openalex.org/keywords/genetic-immunization","display_name":"genetic immunization","score":0.9679999947547913},{"id":"https://openalex.org/keywords/biological-response-modifiers","display_name":"biological response modifiers","score":0.9649999737739563},{"id":"https://openalex.org/keywords/skin-disease-treatment","display_name":"skin disease treatment","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.8176243901252747},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7891542315483093},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.7064697742462158},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.692106306552887},{"id":"https://openalex.org/C168112101","wikidata":"https://www.wikidata.org/wiki/Q1502320","display_name":"Gene gun","level":5,"score":0.6694186329841614},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6252750158309937},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5685011744499207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5133270621299744},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43586212396621704},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31601524353027344},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.2219877541065216},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09294787049293518}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1525-1381.1999.99223.x","doi":"https://doi.org/10.1046/j.1525-1381.1999.99223.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1525-1381.1999.99223.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210222582","display_name":"Proceedings of the Association of American Physicians","issn_l":"1081-650X","issn":["1081-650X","1525-1381"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Association of American Physicians","raw_type":"journal-article"},{"id":"pmid:10354358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10354358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Association of American Physicians","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1971570396","https://openalex.org/W1980332250","https://openalex.org/W1980773456","https://openalex.org/W1981541187","https://openalex.org/W1986241901","https://openalex.org/W1995315280","https://openalex.org/W2000549918","https://openalex.org/W2001297140","https://openalex.org/W2003291241","https://openalex.org/W2003575753","https://openalex.org/W2014495927","https://openalex.org/W2030330210","https://openalex.org/W2035243135","https://openalex.org/W2040848265","https://openalex.org/W2041805971","https://openalex.org/W2042731532","https://openalex.org/W2053501481","https://openalex.org/W2058711337","https://openalex.org/W2071190373","https://openalex.org/W2077394888","https://openalex.org/W2080673718","https://openalex.org/W2081583807","https://openalex.org/W2084129498","https://openalex.org/W2136961696","https://openalex.org/W2142261712","https://openalex.org/W2156521514","https://openalex.org/W2172057856"],"related_works":["https://openalex.org/W1995315280","https://openalex.org/W4246102093","https://openalex.org/W2910749418","https://openalex.org/W2102057936","https://openalex.org/W2030330210","https://openalex.org/W2027372053","https://openalex.org/W2003291241","https://openalex.org/W1999031183","https://openalex.org/W3107247455","https://openalex.org/W2023610505"],"abstract_inverted_index":{"In":[0],"vivo":[1],"gene":[2,22,38],"therapy":[3],"is":[4,29,43],"a":[5],"direct":[6],"and":[7,27,32,56],"effective":[8],"way":[9],"to":[10,63],"express":[11],"genes":[12],"in":[13],"the":[14,20,35,45,57],"epidermis.":[15,36],"Plasmid":[16],"DNA":[17],"that":[18],"contains":[19],"desired":[21],"can":[23],"be":[24],"injected":[25],"intradermally,":[26],"it":[28],"rapidly":[30],"absorbed":[31],"expressed":[33],"by":[34],"Because":[37],"expression":[39,58],"following":[40],"plasmid":[41],"injection":[42],"transient,":[44],"two":[46],"principal":[47],"therapeutic":[48],"uses":[49],"of":[50,59],"this":[51],"approach":[52],"are":[53],"genetic":[54],"immunization":[55],"biological":[60],"response":[61],"modifiers":[62],"treat":[64],"skin":[65],"disease.":[66]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
