{"id":"https://openalex.org/W20825895","doi":"https://doi.org/10.1177/172460089601100306","title":"The Clinical Value of Cyfra 21-1 Estimation for Lung Cancer Patients","display_name":"The Clinical Value of Cyfra 21-1 Estimation for Lung Cancer Patients","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W20825895","doi":"https://doi.org/10.1177/172460089601100306","mag":"20825895","pmid":"https://pubmed.ncbi.nlm.nih.gov/8915713"},"language":"en","primary_location":{"id":"doi:10.1177/172460089601100306","doi":"https://doi.org/10.1177/172460089601100306","is_oa":false,"landing_page_url":"https://doi.org/10.1177/172460089601100306","pdf_url":null,"source":{"id":"https://openalex.org/S155339466","display_name":"The International Journal of Biological Markers","issn_l":"0393-6155","issn":["0393-6155","1724-6008"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biological Markers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017840577","display_name":"M Szturmowicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Szturmowicz","raw_affiliation_strings":["Dept. of Internal Medicine, Warsaw - Poland","Dept. of Internal Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine, Warsaw - Poland","institution_ids":[]},{"raw_affiliation_string":"Dept. of Internal Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027814799","display_name":"Anna Sakowicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Sakowicz","raw_affiliation_strings":["Dept. of Biochemistry, Warsaw - Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biochemistry, Warsaw - Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010866877","display_name":"Patryk Rudzi\u0144ski","orcid":"https://orcid.org/0000-0003-4709-2187","observed_orcids":["https://orcid.org/0000-0003-4709-2187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Rudzinski","raw_affiliation_strings":["Dept. of Thoracic Surgery, Warsaw - Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Thoracic Surgery, Warsaw - Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068433103","display_name":"J Zych","orcid":"https://orcid.org/0009-0001-2821-4487","observed_orcids":["https://orcid.org/0009-0001-2821-4487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Zych","raw_affiliation_strings":["Dept. of Lung Diseases Institute of Tuberculosis and Lung Diseases, Warsaw - Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Lung Diseases Institute of Tuberculosis and Lung Diseases, Warsaw - Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039360953","display_name":"El\u017cbieta Wiatr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Wiatr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069276649","display_name":"Joanna Zaleska","orcid":"https://orcid.org/0000-0002-4417-7831","observed_orcids":["https://orcid.org/0000-0002-4417-7831"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Zal\u0119ska","raw_affiliation_strings":["Dept. of Lung Diseases Institute of Tuberculosis and Lung Diseases, Warsaw - Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Lung Diseases Institute of Tuberculosis and Lung Diseases, Warsaw - Poland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019348253","display_name":"Ewa Rowinska-Zakrzewska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Rowinska-Zakrzewska","raw_affiliation_strings":["Dept. of Lung Diseases Institute of Tuberculosis and Lung Diseases, Warsaw - Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Lung Diseases Institute of Tuberculosis and Lung Diseases, Warsaw - Poland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.5938,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.68170786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"11","issue":"3","first_page":"172","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyfra-21-1","display_name":"CYFRA21-1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8389999866485596},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.7900000214576721},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.953000009059906},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/benign-lung-disease","display_name":"benign lung disease","score":0.8619999885559082},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.6830000281333923},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.8730000257492065},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7110000252723694},{"id":"https://openalex.org/keywords/postoperative-survival","display_name":"postoperative survival","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.8406445384025574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8349477052688599},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.8169435262680054},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.7780463099479675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5769542455673218},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5147011876106262},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48428934812545776},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4758709967136383},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.44640302658081055},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4392060935497284},{"id":"https://openalex.org/C2778911148","wikidata":"https://www.wikidata.org/wiki/Q15979047","display_name":"Large cell","level":4,"score":0.43849846720695496},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4366896152496338},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4333607852458954},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.4132697284221649},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.16704660654067993}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013534","descriptor_name":"Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053539","descriptor_name":"Keratin-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/172460089601100306","doi":"https://doi.org/10.1177/172460089601100306","is_oa":false,"landing_page_url":"https://doi.org/10.1177/172460089601100306","pdf_url":null,"source":{"id":"https://openalex.org/S155339466","display_name":"The International Journal of Biological Markers","issn_l":"0393-6155","issn":["0393-6155","1724-6008"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biological Markers","raw_type":"journal-article"},{"id":"pmid:8915713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8915713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of biological markers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:55c01af98fea483393846b4ca39c25fa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/55c01af98fea483393846b4ca39c25fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The International Journal of Biological Markers, Vol 11 (1996)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W56887765","https://openalex.org/W196658458","https://openalex.org/W1542752109","https://openalex.org/W1977334038","https://openalex.org/W1992287102","https://openalex.org/W1999790977","https://openalex.org/W2017332986","https://openalex.org/W2032302065","https://openalex.org/W2038397881","https://openalex.org/W2052244875","https://openalex.org/W2069810305","https://openalex.org/W2082949505","https://openalex.org/W2084803292","https://openalex.org/W2100266209","https://openalex.org/W2111736738","https://openalex.org/W2159643254","https://openalex.org/W2265126829","https://openalex.org/W2395214496","https://openalex.org/W2418729498","https://openalex.org/W2467419821"],"related_works":["https://openalex.org/W2408500871","https://openalex.org/W2020965042","https://openalex.org/W2408350976","https://openalex.org/W2069810305","https://openalex.org/W2000747263","https://openalex.org/W2267579736","https://openalex.org/W1977217958","https://openalex.org/W2377464612","https://openalex.org/W2062054015","https://openalex.org/W1542752109"],"abstract_inverted_index":{"Cytokeratin-19,":[0],"one":[1],"of":[2,19,27,88,93,103,109,113,183,189],"the":[3,25,157,163,181,186,194],"cytoskeletal":[4],"proteins,":[5],"is":[6],"expressed":[7],"both":[8],"in":[9,13,35,44,53,101,130,140,146,175,185],"bronchial":[10],"epithelium":[11],"and":[12,52,72,90,111,129,162],"lung":[14,36,50,55,63,70,106,116,127,179],"cancer":[15,37,56,71,117,128,180],"cells.":[16],"The":[17,77],"aim":[18],"our":[20],"study":[21],"was":[22,80,121,152,169,191],"to":[23,165],"establish":[24],"value":[26],"serum":[28],"cytokeratin-19":[29],"soluble":[30],"fragment":[31],"(Cyfra":[32],"21-1)":[33],"measurement":[34],"patients.":[38],"Cyfra":[39,96,133,159,167,199],"21-1":[40,97,134,160,168,200],"levels":[41],"were":[42,99,136],"estimated":[43],"35":[45],"patients":[46,141,147,195],"(pts)":[47],"with":[48,60,67,75,85,142,148,196],"benign":[49],"diseases":[51],"116":[54],"patients:":[57],"55":[58],"pts":[59,66,74,118],"squamous":[61,104,125,177],"cell":[62,69,105,115,126,178],"cancer,":[64,107],"38":[65],"small":[68,114],"23":[73],"adenocarcinoma.":[76],"cutoff":[78],"level":[79,161],"set":[81],"at":[82],"4":[83],"ng/ml":[84],"a":[86,91,171],"specificity":[87],"94%":[89],"sensitivity":[92],"40%.":[94],"Elevated":[95],"values":[98,135],"found":[100],"44%":[102],"39%":[108],"adenocarcinoma":[110,131],"34%":[112],"(the":[119],"difference":[120],"not":[122,170],"significant).":[123],"In":[124],"elevated":[132],"observed":[137],"more":[138],"often":[139],"advanced":[143],"disease":[144],"than":[145],"limited":[149],"disease.":[150],"There":[151],"no":[153],"significant":[154],"correlation":[155],"between":[156],"initial":[158],"response":[164],"chemotherapy.":[166],"prognostic":[172],"indicator,":[173],"although":[174],"operable":[176],"proportion":[182],"survivors":[184],"second":[187],"year":[188],"observation":[190],"higher":[192],"among":[193],"normal":[197],"preoperative":[198],"levels.":[201]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}