{"id":"https://openalex.org/W2082573104","doi":"https://doi.org/10.1267/ahc.36.415","title":"Production of Pituitary Hormone by Human Pituitary Adenoma is under Autocrine and Paracrine Regulation of Hypothalamic Hormones Secreted from Adenoma Cells","display_name":"Production of Pituitary Hormone by Human Pituitary Adenoma is under Autocrine and Paracrine Regulation of Hypothalamic Hormones Secreted from Adenoma Cells","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2082573104","doi":"https://doi.org/10.1267/ahc.36.415","mag":"2082573104"},"language":"en","primary_location":{"id":"doi:10.1267/ahc.36.415","doi":"https://doi.org/10.1267/ahc.36.415","is_oa":true,"landing_page_url":"https://doi.org/10.1267/ahc.36.415","pdf_url":"https://www.jstage.jst.go.jp/article/ahc/36/5/36_5_415/_pdf","source":{"id":"https://openalex.org/S151127207","display_name":"ACTA HISTOCHEMICA ET CYTOCHEMICA","issn_l":"0044-5991","issn":["0044-5991","1347-5800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800631","host_organization_name":"Japan Society of Histochemistry and Cytochemistry","host_organization_lineage":["https://openalex.org/P4320800631"],"host_organization_lineage_names":["Japan Society of Histochemistry and Cytochemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA HISTOCHEMICA ET CYTOCHEMICA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/ahc/36/5/36_5_415/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109621979","display_name":"Akira Matsuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Matsuno","raw_affiliation_strings":["Department of Neurosurgery, Teikyo University Ichihara Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Teikyo University Ichihara Hospital","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112082809","display_name":"Tadashi Nagashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Nagashima","raw_affiliation_strings":["Department of Neurosurgery, Teikyo University Ichihara Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Teikyo University Ichihara Hospital","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043958985","display_name":"Hideki Katakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Katakami","raw_affiliation_strings":["Third Department of Internal Medicine, Miyazaki Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Miyazaki Medical College","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109959082","display_name":"Naoko Sanno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Sanno","raw_affiliation_strings":["Department of Neurosurgery, Nippon Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111391650","display_name":"Akira Teramoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Teramoto","raw_affiliation_strings":["Department of Neurosurgery, Nippon Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nippon Medical School","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011873228","display_name":"Susumu Takekoshi","orcid":"https://orcid.org/0000-0001-8815-8643","observed_orcids":["https://orcid.org/0000-0001-8815-8643"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Takekoshi","raw_affiliation_strings":["Department of Pathology, Tokai University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tokai University School of Medicine","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039282044","display_name":"Robert Yoshiyuki OSAMURA","orcid":"https://orcid.org/0000-0001-9126-8640","observed_orcids":["https://orcid.org/0000-0001-9126-8640","https://orcid.org/0009-0006-8196-6860"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Yoshiyuki Osamura","raw_affiliation_strings":["Department of Pathology, Tokai University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tokai University School of Medicine","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087772583","display_name":"Takaaki Kirino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Kirino","raw_affiliation_strings":["Department of Neurosurgery, University of Tokyo Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Tokyo Hospital","institution_ids":["https://openalex.org/I4210109338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110331817","display_name":"Ricardo V. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo V. Lloyd","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1591,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57999066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"5","first_page":"415","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-adenoma","display_name":"pituitary adenoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autocrine-regulation","display_name":"autocrine regulation","score":0.875},{"id":"https://openalex.org/keywords/paracrine-regulation","display_name":"paracrine regulation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypothalamic-hormones","display_name":"hypothalamic hormones","score":0.9850000143051147},{"id":"https://openalex.org/keywords/growth-hormone-releasing-hormone","display_name":"growth hormone-releasing hormone","score":0.9660000205039978},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.984000027179718},{"id":"https://openalex.org/keywords/growth-hormone-secreting-pituitary-adenoma","display_name":"growth hormone-secreting pituitary adenoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/corticotroph-adenoma","display_name":"corticotroph adenoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hormone-receptors","display_name":"hormone receptors","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.8127481937408447},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.7491933107376099},{"id":"https://openalex.org/C94984642","wikidata":"https://www.wikidata.org/wiki/Q3015605","display_name":"Somatotropic cell","level":4,"score":0.7317373752593994},{"id":"https://openalex.org/C2908656328","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamic Hormones","level":4,"score":0.7165567278862},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.6819450259208679},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6506057977676392},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.598594069480896},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5962496995925903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5921576619148254},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.49492329359054565},{"id":"https://openalex.org/C79381400","wikidata":"https://www.wikidata.org/wiki/Q5173293","display_name":"Corticotropic cell","level":4,"score":0.48724642395973206},{"id":"https://openalex.org/C104745856","wikidata":"https://www.wikidata.org/wiki/Q1335366","display_name":"Neuroendocrinology","level":3,"score":0.47765934467315674},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.4760475158691406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42117631435394287},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.41398119926452637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24669212102890015},{"id":"https://openalex.org/C3018374343","wikidata":"https://www.wikidata.org/wiki/Q794835","display_name":"Pituitary hormones","level":3,"score":0.19641521573066711},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1877238154411316}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1267/ahc.36.415","doi":"https://doi.org/10.1267/ahc.36.415","is_oa":true,"landing_page_url":"https://doi.org/10.1267/ahc.36.415","pdf_url":"https://www.jstage.jst.go.jp/article/ahc/36/5/36_5_415/_pdf","source":{"id":"https://openalex.org/S151127207","display_name":"ACTA HISTOCHEMICA ET CYTOCHEMICA","issn_l":"0044-5991","issn":["0044-5991","1347-5800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800631","host_organization_name":"Japan Society of Histochemistry and Cytochemistry","host_organization_lineage":["https://openalex.org/P4320800631"],"host_organization_lineage_names":["Japan Society of Histochemistry and Cytochemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA HISTOCHEMICA ET CYTOCHEMICA","raw_type":"journal-article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0007215323","doi":null,"is_oa":false,"landing_page_url":"https://pure.teikyo.jp/en/publications/a9c9577f-cb32-447d-95c1-f471f9a98282","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Histochemica et Cytochemica","raw_type":"review article"}],"best_oa_location":{"id":"doi:10.1267/ahc.36.415","doi":"https://doi.org/10.1267/ahc.36.415","is_oa":true,"landing_page_url":"https://doi.org/10.1267/ahc.36.415","pdf_url":"https://www.jstage.jst.go.jp/article/ahc/36/5/36_5_415/_pdf","source":{"id":"https://openalex.org/S151127207","display_name":"ACTA HISTOCHEMICA ET CYTOCHEMICA","issn_l":"0044-5991","issn":["0044-5991","1347-5800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800631","host_organization_name":"Japan Society of Histochemistry and Cytochemistry","host_organization_lineage":["https://openalex.org/P4320800631"],"host_organization_lineage_names":["Japan Society of Histochemistry and Cytochemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACTA HISTOCHEMICA ET CYTOCHEMICA","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.616100013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082573104.pdf","grobid_xml":"https://content.openalex.org/works/W2082573104.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W62306675","https://openalex.org/W97530560","https://openalex.org/W102044791","https://openalex.org/W103996602","https://openalex.org/W208321353","https://openalex.org/W316662136","https://openalex.org/W1486299906","https://openalex.org/W1964822553","https://openalex.org/W1970853843","https://openalex.org/W1974012691","https://openalex.org/W1980419912","https://openalex.org/W1982151497","https://openalex.org/W1982164126","https://openalex.org/W1982247801","https://openalex.org/W1993804590","https://openalex.org/W1994590235","https://openalex.org/W1996476319","https://openalex.org/W1997412396","https://openalex.org/W1999151160","https://openalex.org/W2008234050","https://openalex.org/W2010358874","https://openalex.org/W2010935675","https://openalex.org/W2015746719","https://openalex.org/W2016531377","https://openalex.org/W2027002868","https://openalex.org/W2036843175","https://openalex.org/W2048119118","https://openalex.org/W2057304657","https://openalex.org/W2060880761","https://openalex.org/W2062026046","https://openalex.org/W2073656208","https://openalex.org/W2076105668","https://openalex.org/W2076635241","https://openalex.org/W2077599027","https://openalex.org/W2079032505","https://openalex.org/W2079479699","https://openalex.org/W2079669036","https://openalex.org/W2086311038","https://openalex.org/W2091615908","https://openalex.org/W2108739332","https://openalex.org/W2144103254","https://openalex.org/W2147533486","https://openalex.org/W2148981897","https://openalex.org/W2153852419","https://openalex.org/W2169846722","https://openalex.org/W2325285965","https://openalex.org/W2410482914","https://openalex.org/W2480289132","https://openalex.org/W4322698538"],"related_works":["https://openalex.org/W2016531377","https://openalex.org/W2078661968","https://openalex.org/W1970853843","https://openalex.org/W2048119118","https://openalex.org/W4232704691","https://openalex.org/W4243587119","https://openalex.org/W2144103254","https://openalex.org/W1974588102","https://openalex.org/W182256220","https://openalex.org/W2610167303"],"abstract_inverted_index":{"Two":[0],"hypotheses,":[1,6],"the":[2,11,20,33,54,60,68,76],"hypothalamic":[3,57,95],"and":[4,86,97],"pituitary":[5,14,25,34,39,63,104,114],"have":[7],"been":[8],"suggested":[9],"concerning":[10],"pathogenesis":[12],"of":[13,19,22,32,45,56,62,70,78,99,113],"adenoma.":[15,92],"The":[16,72],"recent":[17],"demonstration":[18],"monoclonality":[21],"most":[23],"human":[24,103],"adenomas":[26],"has":[27,65],"led":[28],"to":[29],"wider":[30],"acceptance":[31],"hypothesis,":[35],"which":[36],"suggests":[37],"that":[38],"adenoma":[40,64,105],"results":[41],"from":[42],"monoclonal":[43],"expansion":[44],"a":[46],"single":[47],"adenohypophyseal":[48],"cell":[49],"with":[50],"subcellular":[51],"abnormalities.":[52],"Meanwhile,":[53],"role":[55],"hormones":[58,96],"in":[59,83,90,102,110],"development":[61],"recently":[66],"attracted":[67],"attention":[69],"investigators.":[71],"present":[73],"paper":[74],"discusses":[75],"expression":[77,98],"growth":[79],"hormone-releasing":[80],"hormone":[81,88,115],"(GHRH)":[82],"somatotroph":[84],"adenoma,":[85],"corticotropin-releasing":[87],"(CRH)":[89],"corticotroph":[91],"Locally":[93],"generated":[94],"associated":[100],"receptors":[101],"cells":[106],"play":[107],"significant":[108],"roles":[109],"autocrine/paracrine":[111],"regulation":[112],"production.":[116]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
