{"id":"https://openalex.org/W2082530833","doi":"https://doi.org/10.1677/joe.0.1500121","title":"Influence of insulin-like growth factor-binding protein-2 on plasma clearance and transfer of insulin-like growth factors-I and -II from plasma into mammary-derived lymph and milk of goats","display_name":"Influence of insulin-like growth factor-binding protein-2 on plasma clearance and transfer of insulin-like growth factors-I and -II from plasma into mammary-derived lymph and milk of goats","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2082530833","doi":"https://doi.org/10.1677/joe.0.1500121","mag":"2082530833","pmid":"https://pubmed.ncbi.nlm.nih.gov/8708553"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.1500121","doi":"https://doi.org/10.1677/joe.0.1500121","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1500121","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061007186","display_name":"Colin G. Prosser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C G Prosser","raw_affiliation_strings":["Ruakura Research Centre, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruakura Research Centre, Hamilton, New Zealand","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111711385","display_name":"Juerg Schwander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Schwander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4499,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78730387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"150","issue":"1","first_page":"121","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9490000009536743},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":1.0},{"id":"https://openalex.org/keywords/plasma-clearance","display_name":"plasma clearance","score":0.8510000109672546},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.8379999995231628},{"id":"https://openalex.org/keywords/milk-secretion","display_name":"milk secretion","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mammary-epithelium","display_name":"mammary epithelium","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.671999990940094},{"id":"https://openalex.org/keywords/lactating-goats","display_name":"lactating goats","score":0.9290000200271606},{"id":"https://openalex.org/keywords/igf-binding","display_name":"IGF binding","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7924538850784302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7614976167678833},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.6570954322814941},{"id":"https://openalex.org/C2777332483","wikidata":"https://www.wikidata.org/wiki/Q410116","display_name":"Trichloroacetic acid","level":2,"score":0.6550998687744141},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.5888198614120483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5800930261611938},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.573411762714386},{"id":"https://openalex.org/C80862487","wikidata":"https://www.wikidata.org/wiki/Q415679","display_name":"Somatomedin","level":4,"score":0.5511130094528198},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5440288782119751},{"id":"https://openalex.org/C18206936","wikidata":"https://www.wikidata.org/wiki/Q378749","display_name":"Clearance rate","level":2,"score":0.5061580538749695},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.4800478219985962},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.46266794204711914},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.4275232255458832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2624800205230713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22303494811058044},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13900935649871826},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10952544212341309},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08060407638549805},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008196","descriptor_name":"Lymph","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008196","descriptor_name":"Lymph","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1677/joe.0.1500121","doi":"https://doi.org/10.1677/joe.0.1500121","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1500121","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:8708553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8708553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058358622","https://openalex.org/W2015170438","https://openalex.org/W2131014208","https://openalex.org/W1986288823","https://openalex.org/W2013475910","https://openalex.org/W2047302716","https://openalex.org/W2125320344","https://openalex.org/W1995476527","https://openalex.org/W2091892234","https://openalex.org/W2730291076"],"abstract_inverted_index":{"Plasma":[0],"clearance":[1,279],"of":[2,30,37,41,57,72,116,123,146,155,158,161,171,190,192,212,225,234,245,251,280,285],"insulin-like":[3,12],"growth":[4,13],"factors-I":[5],"and":[6,9,11,54,79,99,134,141,174,179,188,244,256],"-II":[7,75,100,142,175],"(IGF-I":[8],"-II)":[10],"factor-binding":[14],"protein-2":[15],"(IGFBP-2)":[16],"from":[17,59,153,208],"lactating":[18],"goats":[19],"(n":[20],"=":[21],"4)":[22],"was":[23,45,61,86,127,150,197,216],"determined":[24],"following":[25],"a":[26],"single":[27],"intravenous":[28,165],"injection":[29,115],"the":[31,42,117,120,186,223,232,240,249,275,283],"corresponding":[32],"125I-labelled":[33,118],"human":[34],"protein.":[35],"Transfer":[36],"these":[38],"proteins":[39],"out":[40],"vascular":[43,241],"space":[44],"monitored":[46],"by":[47,163,200,219,253],"their":[48],"subsequent":[49,257],"appearance":[50],"in":[51,89,148,222,282],"mammary-derived":[52,195],"lymph":[53,149,196],"milk.":[55,260],"Clearance":[56],"125I-IGFBP-2":[58,147],"circulation":[60],"0.37":[62],"+/-":[63,77,81,96,102,109,129,132,136,177,181],"0.06":[64],"ml/min/kg,":[65],"which":[66],"is":[67],"markedly":[68],"greater":[69],"than":[70],"that":[71,154],"125I-IGF-I":[73],"or":[74],"(0.11":[76],"0.01":[78,82],"0.12":[80],"ml/min/kg":[83],"respectively).":[84,184],"This":[85],"also":[87],"reflected":[88],"longer":[90],"elimination":[91],"half-lives":[92],"for":[93,138],"IGF-I":[94,140,173],"(353":[95],"6":[97],"min)":[98,104],"(254":[101],"8":[103,178],"compared":[105],"with":[106,231],"IGFBP-2":[107,162,246,261],"(110":[108],"9":[110],"min).":[111],"Three":[112],"hours":[113],"after":[114],"protein,":[119],"plasma:lymph":[121],"ratio":[122],"trichloroacetic":[124],"acid-precipitable":[125],"radioactivity":[126],"1.54":[128],"0.04,":[130],"3.3":[131],"0.6":[133],"4.1":[135],"0.4":[137],"IGFBP-2,":[139,201,220],"respectively.":[143],"The":[144],"form":[145],"not":[151,206],"different":[152,207],"plasma.":[156],"Elevation":[157],"plasma":[159,169,268,278],"concentrations":[160,202],"its":[164],"infusion":[166],"significantly":[167,217],"decreased":[168,198],"half-life":[170],"both":[172],"(251":[176],"198":[180],"7":[182],"min":[183],"Although":[185],"amount":[187],"rate":[189],"transfer":[191],"IGF":[193,252,269],"into":[194,214,259],"slightly":[199],"eventually":[203],"obtained":[204],"were":[205],"control.":[209],"However,":[210],"secretion":[211,258],"IGFs":[213,281],"milk":[215],"reduced":[218],"particularly":[221],"case":[224],"IGF-I.":[226],"These":[227],"results":[228],"are":[229],"consistent":[230],"ability":[233],"all":[235],"three":[236],"compounds":[237],"to":[238,247,266],"cross":[239],"endothelium":[242],"intact":[243],"decrease":[248],"uptake":[250],"mammary":[254],"epithelium":[255],"may":[262],"well":[263],"have":[264],"acted":[265],"target":[267],"towards":[270],"non-mammary":[271],"tissues,":[272],"thus":[273],"explaining":[274],"more":[276],"rapid":[277],"presence":[284],"elevated":[286],"IGFBP-2.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
