{"id":"https://openalex.org/W2082465321","doi":"https://doi.org/10.1186/1756-0500-7-595","title":"A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro","display_name":"A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro","publication_year":2014,"publication_date":"2014-09-03","ids":{"openalex":"https://openalex.org/W2082465321","doi":"https://doi.org/10.1186/1756-0500-7-595","mag":"2082465321","pmid":"https://pubmed.ncbi.nlm.nih.gov/25186493","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161845"},"language":"en","primary_location":{"id":"doi:10.1186/1756-0500-7-595","doi":"https://doi.org/10.1186/1756-0500-7-595","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-7-595","pdf_url":"https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/1756-0500-7-595","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/1756-0500-7-595","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102077770","display_name":"Mahesh Kumar Verma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mahesh Kumar Verma","raw_affiliation_strings":["Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","Connexios Life Sciences Private Ltd., JP Nagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","institution_ids":["https://openalex.org/I4210105948"]},{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., JP Nagar, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063148010","display_name":"Sanghamitra Biswas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanghamitra Biswas","raw_affiliation_strings":["Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","Connexios Life Sciences Private Ltd., JP Nagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","institution_ids":["https://openalex.org/I4210105948"]},{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., JP Nagar, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053638858","display_name":"Bhawna Chandravanshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhawna Chandravanshi","raw_affiliation_strings":["Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","Connexios Life Sciences Private Ltd., JP Nagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","institution_ids":["https://openalex.org/I4210105948"]},{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., JP Nagar, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037778361","display_name":"Korrapati Neelima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Korrapati Neelima","raw_affiliation_strings":["Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","Connexios Life Sciences Private Ltd., JP Nagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","institution_ids":["https://openalex.org/I4210105948"]},{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., JP Nagar, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084588976","display_name":"Anup Mammen Oommen","orcid":"https://orcid.org/0000-0001-7653-5106","observed_orcids":["https://orcid.org/0000-0001-7653-5106"]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anup M Oommen","raw_affiliation_strings":["Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","Connexios Life Sciences Private Ltd., JP Nagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","institution_ids":["https://openalex.org/I4210105948"]},{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., JP Nagar, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113692534","display_name":"Madanahalli R Jagannath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Madanahalli R Jagannath","raw_affiliation_strings":["Connexios Life Sciences Private Ltd,, No, 49, First Main road, 3rd phase, JP Nagar, Bangalore 560 078, India. m.r.jagannath@connexios.com","Connexios Life Sciences Private Ltd., JP Nagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Private Ltd,, No, 49, First Main road, 3rd phase, JP Nagar, Bangalore 560 078, India. m.r.jagannath@connexios.com","institution_ids":["https://openalex.org/I4210105948"]},{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., JP Nagar, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040052186","display_name":"Baggavalli P Somesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Baggavalli P Somesh","raw_affiliation_strings":["Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","Connexios Life Sciences Private Ltd., JP Nagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., No. 49, First Main road, 3rd phase, JP Nagar, Bangalore, 560 078, India","institution_ids":["https://openalex.org/I4210105948"]},{"raw_affiliation_string":"Connexios Life Sciences Private Ltd., JP Nagar, India","institution_ids":["https://openalex.org/I4210105948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113692534"],"corresponding_institution_ids":["https://openalex.org/I4210105948"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":0.8719,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.74548411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"595","last_page":"595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr40","display_name":"GPR40","score":0.875},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glucolipotoxicity","display_name":"glucolipotoxicity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9950000047683716},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.8840000033378601},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.47999998927116394},{"id":"https://openalex.org/keywords/insulin-glucagon-interaction","display_name":"insulin-glucagon interaction","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C32670627","wikidata":"https://www.wikidata.org/wiki/Q18026423","display_name":"Free fatty acid receptor 1","level":4,"score":0.9057583808898926},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.8232921361923218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8113802075386047},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7790360450744629},{"id":"https://openalex.org/C2780768396","wikidata":"https://www.wikidata.org/wiki/Q66310097","display_name":"Proglucagon","level":5,"score":0.7031080722808838},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6767062544822693},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.5198119878768921},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.45090973377227783},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4363839626312256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4241233766078949},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4043756127357483},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.38271963596343994},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3370833396911621},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.32596608996391296},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30800625681877136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.290303111076355}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1756-0500-7-595","doi":"https://doi.org/10.1186/1756-0500-7-595","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-7-595","pdf_url":"https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/1756-0500-7-595","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4161845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161845","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Res Notes","raw_type":"Text"},{"id":"pmid:25186493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25186493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC research notes","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1756-0500-7-595","doi":"https://doi.org/10.1186/1756-0500-7-595","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-7-595","pdf_url":"https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/1756-0500-7-595","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082465321.pdf","grobid_xml":"https://content.openalex.org/works/W2082465321.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1984541901","https://openalex.org/W2041346929","https://openalex.org/W2087497757","https://openalex.org/W2100958442","https://openalex.org/W2104221319","https://openalex.org/W2109314419","https://openalex.org/W2128326754","https://openalex.org/W2153770190","https://openalex.org/W2157207349","https://openalex.org/W2170455952","https://openalex.org/W2402922148"],"related_works":["https://openalex.org/W2157207349","https://openalex.org/W2139907919","https://openalex.org/W2077312439","https://openalex.org/W7099647648","https://openalex.org/W7098660747","https://openalex.org/W2397497372","https://openalex.org/W1964938698","https://openalex.org/W1410003609","https://openalex.org/W2062958205","https://openalex.org/W2138309074"],"abstract_inverted_index":{"BACKGROUND:":[0],"Elevated":[1],"glucose":[2,47,65,107,130],"concentrations":[3,48],"lead":[4],"to":[5,37,75],"increased":[6,128],"insulin":[7,16,33,67],"secretion":[8,44,68,86,98,133,171],"and":[9,93,134],"suppression":[10,41],"of":[11,21,40,42,79,110,146,159,164],"glucagon":[12,22,43,85,116,132,170],"secretion.":[13,23,34,117],"In":[14,35],"fact,":[15],"is":[17,49],"a":[18],"physiological":[19],"inhibitor":[20],"Type":[24],"2":[25],"diabetes":[26],"mellitus":[27],"(T2DM)":[28],"patients":[29],"have":[30,56,126],"defects":[31],"in":[32,52,154],"addition":[36],"this,":[38],"lack":[39],"under":[45,90,105,120,152],"elevated":[46,106],"also":[50],"observed":[51,127],"T2DM":[53],"patients.":[54],"We":[55],"earlier":[57],"shown":[58],"that":[59],"GPR40":[60,80,111,140,160,165],"activation":[61,81,141],"by":[62,82,112,142,166],"CNX-011-67":[63,83,113,167],"stimulates":[64],"stimulated":[66],"(GSIS).":[69],"Here":[70],"we":[71,125],"extended":[72],"our":[73],"studies":[74],"examine":[76],"the":[77,155],"impact":[78],"on":[84],"from":[87,99,172],"intact":[88,100],"islets":[89,102,119],"both":[91],"normal":[92],"glucolipotoxic":[94,122],"conditions.":[95],"FINDINGS:":[96],"Glucagon":[97],"rat":[101],"was":[103],"suppressed":[104,115],"concentration.":[108],"Activation":[109,163],"further":[114],"Culturing":[118],"chronic":[121],"(GL)":[123],"conditions,":[124],"high":[129],"mediated":[131],"content":[135],"which":[136],"were":[137],"reduced":[138],"with":[139],"CNX-011-67.":[143],"Interestingly,":[144],"expression":[145],"pre-proglucagon":[147],"gene":[148],"(GCG)":[149],"remained":[150],"unchanged":[151],"glucolipotoxicity":[153],"presence":[156],"or":[157],"absence":[158],"activation.":[161],"CONCLUSION:":[162],"can":[168],"reduce":[169],"pancreatic":[173],"islets.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}