{"id":"https://openalex.org/W2082464247","doi":"https://doi.org/10.1038/sj.bjp.0707296","title":"The nematode neuropeptide, AF2 (KHEYLRF\u2010NH2), increases voltage\u2010activated calcium currents in Ascaris suum muscle","display_name":"The nematode neuropeptide, AF2 (KHEYLRF\u2010NH2), increases voltage\u2010activated calcium currents in Ascaris suum muscle","publication_year":2007,"publication_date":"2007-05-29","ids":{"openalex":"https://openalex.org/W2082464247","doi":"https://doi.org/10.1038/sj.bjp.0707296","mag":"2082464247","pmid":"https://pubmed.ncbi.nlm.nih.gov/17519945","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2014128"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0707296","doi":"https://doi.org/10.1038/sj.bjp.0707296","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0707296","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707296","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069877461","display_name":"Saurabh Verma","orcid":"https://orcid.org/0000-0003-1417-0986","observed_orcids":["https://orcid.org/0000-0003-1417-0986"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Verma","raw_affiliation_strings":["Department of Biomedical Science, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA","Department of Biomedical Science, College of Veterinary Medicine, Iowa State University, Ames, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Department of Biomedical Science, College of Veterinary Medicine, Iowa State University, Ames, IA, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002068300","display_name":"Alan Patrick Robertson","orcid":"https://orcid.org/0000-0002-7980-1139","observed_orcids":["https://orcid.org/0000-0002-7980-1139"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A P Robertson","raw_affiliation_strings":["Department of Biomedical Science, College of Veterinary Medicine, Iowa State University, Ames, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, College of Veterinary Medicine, Iowa State University, Ames, IA, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033749081","display_name":"Richard J. Martin","orcid":"https://orcid.org/0000-0003-2422-1847","observed_orcids":["https://orcid.org/0000-0003-2422-1847"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R J Martin","raw_affiliation_strings":["Department of Biomedical Science, College of Veterinary Medicine, Iowa State University, Ames, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, College of Veterinary Medicine, Iowa State University, Ames, IA, USA","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033749081"],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":3.9817,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.92460177,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"151","issue":"6","first_page":"888","last_page":"899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.2809999883174896,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.10980000346899033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascaris-suum","display_name":"Ascaris suum","score":0.9409999847412109},{"id":"https://openalex.org/keywords/voltage-activated-calcium-currents","display_name":"voltage-activated calcium currents","score":0.9100000262260437},{"id":"https://openalex.org/keywords/non-l-type-calcium-channels","display_name":"non-L-type calcium channels","score":0.7960000038146973},{"id":"https://openalex.org/keywords/neuromuscular-excitability","display_name":"neuromuscular excitability","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anthelmintic-resistance","display_name":"anthelmintic resistance","score":0.8579999804496765},{"id":"https://openalex.org/keywords/benzimidazole-resistance","display_name":"benzimidazole resistance","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cholinergic-agonists","display_name":"cholinergic agonists","score":0.6970000267028809},{"id":"https://openalex.org/keywords/avermectin-resistance","display_name":"avermectin resistance","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C2779845534","wikidata":"https://www.wikidata.org/wiki/Q2062253","display_name":"Ascaris suum","level":3,"score":0.8262119293212891},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.5218554735183716},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.51270592212677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5121605396270752},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5076509714126587},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.4722656011581421},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.46245265007019043},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45074230432510376},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.43597960472106934},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4357338845729828},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3715413808822632},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3373602330684662},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.336603581905365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3262634873390198},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.24630507826805115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16838020086288452},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.125984787940979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12319967150688171},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017165","descriptor_name":"Ascaris suum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjp.0707296","doi":"https://doi.org/10.1038/sj.bjp.0707296","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0707296","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707296","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2014128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2014128","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:17519945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17519945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjp.0707296","doi":"https://doi.org/10.1038/sj.bjp.0707296","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0707296","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707296","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G286866916","display_name":"Pharmacological Diversity of nAChRs in Clade III Nematodes: Brugia malayi","funder_award_id":"R01AI047194","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082464247.pdf","grobid_xml":"https://content.openalex.org/works/W2082464247.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1488629111","https://openalex.org/W1549225872","https://openalex.org/W1616459298","https://openalex.org/W1940548560","https://openalex.org/W1966214419","https://openalex.org/W1968184443","https://openalex.org/W1971446667","https://openalex.org/W1973889897","https://openalex.org/W1991668690","https://openalex.org/W2002388280","https://openalex.org/W2004149354","https://openalex.org/W2007289934","https://openalex.org/W2008758297","https://openalex.org/W2022513329","https://openalex.org/W2024226546","https://openalex.org/W2027971247","https://openalex.org/W2037333830","https://openalex.org/W2037645437","https://openalex.org/W2043889722","https://openalex.org/W2045413829","https://openalex.org/W2049707579","https://openalex.org/W2051789222","https://openalex.org/W2052505011","https://openalex.org/W2061056399","https://openalex.org/W2062189135","https://openalex.org/W2067459039","https://openalex.org/W2075220817","https://openalex.org/W2079441999","https://openalex.org/W2089584592","https://openalex.org/W2090157435","https://openalex.org/W2090756172","https://openalex.org/W2091959972","https://openalex.org/W2099687404","https://openalex.org/W2112520390","https://openalex.org/W2113272349","https://openalex.org/W2123976402","https://openalex.org/W2125824307","https://openalex.org/W2126508762","https://openalex.org/W2128079521","https://openalex.org/W2128674161","https://openalex.org/W2132167213","https://openalex.org/W2136941762","https://openalex.org/W2148044601","https://openalex.org/W2150670949","https://openalex.org/W2199016323"],"related_works":["https://openalex.org/W2007289934","https://openalex.org/W43344108","https://openalex.org/W6940828247","https://openalex.org/W2046876882","https://openalex.org/W2132167213","https://openalex.org/W2418466711","https://openalex.org/W2057494513","https://openalex.org/W2090756172","https://openalex.org/W2088694226","https://openalex.org/W2043896781"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,173],"PURPOSE:":[2],"Resistance":[3],"to":[4,46,104,142,158,169,207,221],"all":[5],"the":[6,12,59,73,90,129,136,147,150,163,184,187,202,209],"classes":[7],"of":[8,24,30,40,61,83,92,117,186,201],"anti-nematodal":[9],"drugs":[10],"like":[11],"benzimidazoles,":[13],"cholinergic":[14,215],"agonists":[15],"and":[16,36,76,79,161,211,217],"avermectins,":[17],"has":[18],"now":[19],"been":[20,44],"recorded":[21],"in":[22,65,102,128,149,194],"parasites":[23],"animals":[25],"and/or":[26],"humans.":[27],"The":[28],"development":[29],"novel":[31,52],"anthelmintics":[32,216],"is":[33,205],"an":[34],"urgent":[35],"imperative":[37],"need.":[38],"Receptors":[39],"nematode":[41],"neuropeptides":[42],"have":[43],"suggested":[45],"be":[47],"suitable":[48],"target":[49],"sites":[50],"for":[51],"anthelmintic":[53],"drugs.":[54],"EXPERIMENTAL":[55],"APPROACH:":[56],"To":[57],"investigate":[58],"effect":[60],"AF2":[62,120,134,182,203],"on":[63],"calcium-currents":[64],"Ascaris":[66],"suum":[67],"somatic":[68],"muscle":[69],"cells":[70],"we":[71,88],"employed":[72],"two-micropipette":[74],"current-clamp":[75],"voltage-clamp":[77],"techniques":[78],"a":[80,114,124,178],"brief":[81],"application":[82,116],"AF2.":[84],"KEY":[85],"RESULTS:":[86],"Here":[87],"report":[89],"isolation":[91],"voltage-activated,":[93],"transient,":[94],"inward":[95,131],"calcium":[96,111,132,192],"currents.":[97,112],"These":[98,175],"currents":[99,193],"are":[100],"similar":[101],"characteristics":[103],"Caenorhabditis":[105],"elegans":[106],"UNC-2":[107],"type":[108],"currents,":[109],"non-L-type":[110],"Following":[113],"2-minute":[115],"1":[118],"microM":[119],",":[121],"there":[122],"was":[123],"significant":[125],"long-lasting":[126],"increase":[127,208],"transient":[130],"current;":[133],"increased":[135,183],"maximum":[137,164],"current":[138],"(from":[139],"-84":[140],"nA":[141],"-158":[143],"nA)":[144],"by":[145,180,190],"shifting":[146],"threshold":[148],"hyperpolarising":[151],"direction":[152],"(V":[153],"(50)":[154],"changed":[155],"from":[156,167],"-7.2":[157],"-12.8":[159],"mV)":[160],"increasing":[162],"conductance":[165],"change":[166],"1.91":[168],"2.94":[170],"microS.":[171],"CONCLUSION":[172],"IMPLICATIONS:":[174],"studies":[176],"demonstrate":[177],"mechanism":[179],"which":[181],"excitability":[185],"neuromuscular":[188],"system":[189],"modulating":[191],"nematodes.":[195],"A":[196],"selective":[197],"small":[198],"molecule":[199],"agonist":[200],"receptor":[204],"predicted":[206],"contraction":[210],"act":[212],"synergistically":[213],"with":[214],"could":[218],"counter":[219],"resistance":[220],"these":[222],"compounds.":[223]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}