{"id":"https://openalex.org/W2082439972","doi":"https://doi.org/10.1110/ps.0358803","title":"Molecular modeling of the membrane targeting of phospholipase C pleckstrin homology domains","display_name":"Molecular modeling of the membrane targeting of phospholipase C pleckstrin homology domains","publication_year":2003,"publication_date":"2003-08-27","ids":{"openalex":"https://openalex.org/W2082439972","doi":"https://doi.org/10.1110/ps.0358803","mag":"2082439972","pmid":"https://pubmed.ncbi.nlm.nih.gov/12930993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2323991"},"language":"en","primary_location":{"id":"doi:10.1110/ps.0358803","doi":"https://doi.org/10.1110/ps.0358803","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.0358803","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.0358803","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.0358803","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082996631","display_name":"Shaneen M Singh","orcid":"https://orcid.org/0000-0002-4003-5756","observed_orcids":["https://orcid.org/0000-0002-4003-5756"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaneen M. Singh","raw_affiliation_strings":["Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081710529","display_name":"Diana Murray","orcid":"https://orcid.org/0000-0003-4121-1536","observed_orcids":["https://orcid.org/0000-0003-4121-1536"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diana Murray","raw_affiliation_strings":["Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081710529"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":2.4136,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.88853538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"9","first_page":"1934","last_page":"1953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.22010000050067902,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ph-domain","display_name":"pleckstrin homology domain","score":0.9929999709129333},{"id":"https://openalex.org/keywords/membrane-targeting","display_name":"membrane targeting","score":0.9629999995231628},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.8330000042915344},{"id":"https://openalex.org/keywords/phospholipase-c-delta1","display_name":"phospholipase C delta 1","score":0.7639999985694885},{"id":"https://openalex.org/keywords/phospholipase-c-beta","display_name":"phospholipase C beta","score":0.8029999732971191},{"id":"https://openalex.org/keywords/phospholipase-c-gamma","display_name":"phospholipase C-gamma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.6669999957084656},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/lipid-binding","display_name":"lipid binding","score":0.3709999918937683},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"protein structure prediction","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C49658373","wikidata":"https://www.wikidata.org/wiki/Q24776397","display_name":"Pleckstrin homology domain","level":3,"score":0.9652737975120544},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5564497113227844},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.5361303091049194},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.49143779277801514},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.476390540599823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.469982773065567},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.4246291518211365},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4174407720565796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3602760434150696},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.32969745993614197},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3162713050842285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2948554456233978},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17912593483924866}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054801","descriptor_name":"Phosphoinositide Phospholipase C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054803","descriptor_name":"Phospholipase C delta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1110/ps.0358803","doi":"https://doi.org/10.1110/ps.0358803","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.0358803","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.0358803","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2323991","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2323991","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:12930993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12930993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1110/ps.0358803","doi":"https://doi.org/10.1110/ps.0358803","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.0358803","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.0358803","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1355774524","display_name":null,"funder_award_id":"GM-66147","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1585594050","display_name":"Computational analysis of protein/membrane interactions","funder_award_id":"R01GM066147","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2082439972.pdf"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W154314917","https://openalex.org/W1234417371","https://openalex.org/W1486102976","https://openalex.org/W1499450468","https://openalex.org/W1518153787","https://openalex.org/W1524556134","https://openalex.org/W1558700872","https://openalex.org/W1582659466","https://openalex.org/W1602800967","https://openalex.org/W1617760412","https://openalex.org/W1884928912","https://openalex.org/W1895415431","https://openalex.org/W1958742527","https://openalex.org/W1964011658","https://openalex.org/W1964442771","https://openalex.org/W1970692622","https://openalex.org/W1971113488","https://openalex.org/W1977170693","https://openalex.org/W1977922844","https://openalex.org/W1979817897","https://openalex.org/W1981182586","https://openalex.org/W1985435142","https://openalex.org/W1987215061","https://openalex.org/W1994063020","https://openalex.org/W1995846848","https://openalex.org/W1997784032","https://openalex.org/W1998712463","https://openalex.org/W1999493392","https://openalex.org/W2000774142","https://openalex.org/W2001557131","https://openalex.org/W2002659345","https://openalex.org/W2003997759","https://openalex.org/W2004228538","https://openalex.org/W2004357717","https://openalex.org/W2006455216","https://openalex.org/W2008726339","https://openalex.org/W2011214599","https://openalex.org/W2011313782","https://openalex.org/W2012992067","https://openalex.org/W2014065789","https://openalex.org/W2016441216","https://openalex.org/W2018001030","https://openalex.org/W2021534482","https://openalex.org/W2021717885","https://openalex.org/W2022964566","https://openalex.org/W2026593599","https://openalex.org/W2027557494","https://openalex.org/W2028125482","https://openalex.org/W2028843689","https://openalex.org/W2031815624","https://openalex.org/W2032518125","https://openalex.org/W2037303082","https://openalex.org/W2038126024","https://openalex.org/W2041305500","https://openalex.org/W2042866020","https://openalex.org/W2047163848","https://openalex.org/W2048622566","https://openalex.org/W2051889119","https://openalex.org/W2055043387","https://openalex.org/W2065283382","https://openalex.org/W2065928074","https://openalex.org/W2066094617","https://openalex.org/W2067173516","https://openalex.org/W2068488447","https://openalex.org/W2069109360","https://openalex.org/W2071486470","https://openalex.org/W2072459093","https://openalex.org/W2075095368","https://openalex.org/W2079173223","https://openalex.org/W2079685674","https://openalex.org/W2080264403","https://openalex.org/W2082688327","https://openalex.org/W2084466582","https://openalex.org/W2087064593","https://openalex.org/W2089663411","https://openalex.org/W2090429239","https://openalex.org/W2092249847","https://openalex.org/W2092275582","https://openalex.org/W2093253631","https://openalex.org/W2094841666","https://openalex.org/W2096549360","https://openalex.org/W2099752571","https://openalex.org/W2102436071","https://openalex.org/W2106154817","https://openalex.org/W2106315897","https://openalex.org/W2106882534","https://openalex.org/W2107566660","https://openalex.org/W2112012991","https://openalex.org/W2112305018","https://openalex.org/W2114049512","https://openalex.org/W2117111749","https://openalex.org/W2119806797","https://openalex.org/W2121560377","https://openalex.org/W2128442209","https://openalex.org/W2132021366","https://openalex.org/W2134299061","https://openalex.org/W2138741360","https://openalex.org/W2140514445","https://openalex.org/W2142182637","https://openalex.org/W2142529984","https://openalex.org/W2143173841","https://openalex.org/W2144362290","https://openalex.org/W2144667265","https://openalex.org/W2148853951","https://openalex.org/W2152326664","https://openalex.org/W2158714788","https://openalex.org/W2161840436","https://openalex.org/W2162166182","https://openalex.org/W2165448884","https://openalex.org/W2168721537","https://openalex.org/W2169007182","https://openalex.org/W2271504699","https://openalex.org/W2344259232","https://openalex.org/W2399849921","https://openalex.org/W2418906184","https://openalex.org/W2424380709","https://openalex.org/W2425190918"],"related_works":["https://openalex.org/W1520458304","https://openalex.org/W2425190918","https://openalex.org/W2082688327","https://openalex.org/W2051889119","https://openalex.org/W1997784032","https://openalex.org/W2026940376","https://openalex.org/W2068488447","https://openalex.org/W1997690717","https://openalex.org/W2889279498","https://openalex.org/W2091349420"],"abstract_inverted_index":{"Phospholipases":[0],"C":[1],"(PLCs)":[2],"reversibly":[3],"associate":[4],"with":[5,63,155,227],"membranes":[6],"to":[7,36,209],"hydrolyze":[8],"phosphatidylinositol-4,":[9],"5-bisphosphate":[10],"(PI[4,5]P(2))":[11],"and":[12,20,66,68,128,158,216,219,264],"comprise":[13],"four":[14,187],"main":[15],"classes:":[16],"beta,":[17],"gamma,":[18],"delta,":[19],"epsilon.":[21],"Most":[22],"eukaryotic":[23],"PLCs":[24],"contain":[25],"a":[26,47,72,143,248,255,258],"single,":[27],"N-terminal":[28],"pleckstrin":[29],"homology":[30],"(PH)":[31],"domain,":[32,51],"which":[33],"is":[34],"thought":[35],"play":[37],"an":[38],"important":[39],"role":[40],"in":[41,98,171,202],"membrane":[42,93,211],"targeting.":[43],"The":[44],"structure":[45],"of":[46,92,118,146,185,213,225,241,261],"single":[48],"PLC":[49,87,121,188,243],"PH":[50,59,75,83,122,153,200,237],"that":[52,82,180,267],"from":[53,85,183,239],"PLCdelta1,":[54],"has":[55,69],"been":[56],"determined;":[57],"this":[58],"domain":[60,76],"binds":[61],"PI(4,5)P(2)":[62],"high":[64],"affinity":[65],"stereospecificity":[67],"served":[70],"as":[71,254],"paradigm":[73],"for":[74,108,142,151,162,199,236,257],"functionality.":[77],"However,":[78],"experimental":[79,147],"studies":[80],"demonstrate":[81,246],"domains":[84,123,154,201,238],"different":[86,192],"classes":[88,189,244],"exhibit":[89,190],"diverse":[90],"modes":[91],"interaction,":[94],"reflecting":[95],"the":[96,105,115,166,172,186,210,223,242],"dissimilarity":[97],"their":[99,109,130],"amino":[100],"acid":[101],"sequences.":[102],"To":[103],"elucidate":[104],"structural":[106,250],"basis":[107],"differential":[110],"membrane-binding":[111],"specificities,":[112],"we":[113],"modeled":[114],"three-dimensional":[116],"structures":[117],"all":[119,240],"mammalian":[120],"by":[124,133],"using":[125,134],"bioinformatic":[126],"tools":[127],"calculated":[129],"biophysical":[131,265],"properties":[132,266],"continuum":[135],"electrostatic":[136,193,206,231],"approaches.":[137],"Our":[138,233],"computational":[139],"analysis":[140],"accounts":[141],"large":[144],"body":[145],"data,":[148],"provides":[149],"predictions":[150],"those":[152,196],"unknown":[156],"functions,":[157],"indicates":[159],"functional":[160,270],"roles":[161],"regions":[163],"other":[164],"than":[165,195],"canonical":[167],"lipid-binding":[168],"site":[169],"identified":[170],"PLCdelta1-PH":[173],"structure.":[174],"In":[175],"particular,":[176],"our":[177],"calculations":[178],"predict":[179],"(1).":[181],"members":[182],"each":[184],"strikingly":[191],"profiles":[194],"ordinarily":[197],"observed":[198],"general,":[203],"(2).":[204],"nonspecific":[205],"interactions":[207],"contribute":[208],"localization":[212],"PLCdelta-,":[214],"PLCgamma-,":[215],"PLCbeta-PH":[217,226],"domains,":[218],"(3).":[220],"phosphorylation":[221],"regulates":[222],"interaction":[224],"its":[228],"effectors":[229],"through":[230],"repulsion.":[232],"molecular":[234],"models":[235],"clearly":[245],"how":[247],"common":[249],"fold":[251],"can":[252],"serve":[253],"scaffold":[256],"wide":[259],"range":[260],"surface":[262],"features":[263],"support":[268],"distinctive":[269],"roles.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}