{"id":"https://openalex.org/W2082392586","doi":"https://doi.org/10.1038/sj.gt.3301116","title":"Development of synthetic promoters for radiation-mediated gene therapy","display_name":"Development of synthetic promoters for radiation-mediated gene therapy","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2082392586","doi":"https://doi.org/10.1038/sj.gt.3301116","mag":"2082392586","pmid":"https://pubmed.ncbi.nlm.nih.gov/10757025"},"language":"en","primary_location":{"id":"doi:10.1038/sj.gt.3301116","doi":"https://doi.org/10.1038/sj.gt.3301116","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.gt.3301116","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074559844","display_name":"Brian Marples","orcid":"https://orcid.org/0000-0002-8684-4372","observed_orcids":["https://orcid.org/0000-0002-8684-4372"]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B Marples","raw_affiliation_strings":["Cancer Research Campaign Section of Genome Damage and Repair, Paterson Institute for Cancer Research, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Section of Genome Damage and Repair, Paterson Institute for Cancer Research, Manchester, UK","institution_ids":["https://openalex.org/I4210129527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077287191","display_name":"Simon D. Scott","orcid":"https://orcid.org/0000-0002-8290-0461","observed_orcids":["https://orcid.org/0000-0002-8290-0461"]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S D Scott","raw_affiliation_strings":["Cancer Research Campaign Section of Genome Damage and Repair, Christie Hospital (NHS) Trust, Manchester, UK","Experimental Oncology, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Section of Genome Damage and Repair, Christie Hospital (NHS) Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Experimental Oncology, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, UK","institution_ids":["https://openalex.org/I2801038905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110112805","display_name":"J.H. Hendry","orcid":"https://orcid.org/0000-0002-6988-1278","observed_orcids":["https://orcid.org/0000-0002-6988-1278"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J H Hendry","raw_affiliation_strings":["Cancer Research Campaign Section of Genome Damage and Repair, Christie Hospital (NHS) Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Section of Genome Damage and Repair, Christie Hospital (NHS) Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111836819","display_name":"M. J. Embleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M J Embleton","raw_affiliation_strings":["Cancer Research Campaign Section of Cell and Tumour Biology, Christie Hospital (NHS) Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Section of Cell and Tumour Biology, Christie Hospital (NHS) Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112315132","display_name":"L. S. Lashford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L S Lashford","raw_affiliation_strings":["Paterson Institute for Cancer Research and Academic Department of Paediatric Oncology, Cancer Research Campaign Section of Haemopoietic Cell and Gene Therapeutics, Christie Hospital (NHS) Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paterson Institute for Cancer Research and Academic Department of Paediatric Oncology, Cancer Research Campaign Section of Haemopoietic Cell and Gene Therapeutics, Christie Hospital (NHS) Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077801086","display_name":"Geoffrey P. Margison","orcid":"https://orcid.org/0009-0001-5471-918X","observed_orcids":["https://orcid.org/0009-0001-5471-918X"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G P Margison","raw_affiliation_strings":["Cancer Research Campaign Section of Genome Damage and Repair, Christie Hospital (NHS) Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Section of Genome Damage and Repair, Christie Hospital (NHS) Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":5.1223,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.95662917,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"6","first_page":"511","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-promoters","display_name":"synthetic promoters","score":0.7929999828338623},{"id":"https://openalex.org/keywords/carg-elements","display_name":"CArG elements","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.7490000128746033},{"id":"https://openalex.org/keywords/low-dose-radiation","display_name":"low-dose radiation","score":0.671999990940094},{"id":"https://openalex.org/keywords/fractionated-radiotherapy","display_name":"fractionated radiotherapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/herpes-simplex-virus-thymidine-kinase","display_name":"herpes simplex virus thymidine kinase","score":0.859000027179718},{"id":"https://openalex.org/keywords/ganciclovir","display_name":"ganciclovir","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/radiation-induced-gene-expression","display_name":"radiation-induced gene expression","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6668517589569092},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.6434286236763},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.634482741355896},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6336026787757874},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.608040988445282},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5766718983650208},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5602742433547974},{"id":"https://openalex.org/C2776147627","wikidata":"https://www.wikidata.org/wiki/Q24783855","display_name":"Thymidine kinase","level":4,"score":0.5186985731124878},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5154396295547485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48487576842308044},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.44834181666374207},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43903812766075134},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4363860487937927},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.2815103530883789},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1463901400566101},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13315808773040771},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.07827216386795044}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.gt.3301116","doi":"https://doi.org/10.1038/sj.gt.3301116","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.gt.3301116","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},{"id":"pmid:10757025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10757025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene therapy","raw_type":"Journal Article"},{"id":"pmh:oai:gala.gre.ac.uk:8479","doi":null,"is_oa":false,"landing_page_url":"http://gala.gre.ac.uk/id/eprint/8479/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401244","display_name":"Greenwich Academic Literature Archive (University of Greenwich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55060895","host_organization_name":"University of Greenwich","host_organization_lineage":["https://openalex.org/I55060895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:kar.kent.ac.uk:45898","doi":null,"is_oa":false,"landing_page_url":"https://kar.kent.ac.uk/45898/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196264","display_name":"Kent Academic Repository (University of Kent)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20581793","host_organization_name":"University of Kent","host_organization_lineage":["https://openalex.org/I20581793"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W30787534","https://openalex.org/W1534245360","https://openalex.org/W1581420049","https://openalex.org/W1883847229","https://openalex.org/W1978645874","https://openalex.org/W1990527311","https://openalex.org/W2003634190","https://openalex.org/W2004480518","https://openalex.org/W2011229774","https://openalex.org/W2015481819","https://openalex.org/W2015523852","https://openalex.org/W2023246619","https://openalex.org/W2024356087","https://openalex.org/W2037148821","https://openalex.org/W2041174612","https://openalex.org/W2042299243","https://openalex.org/W2045217703","https://openalex.org/W2050912993","https://openalex.org/W2052885484","https://openalex.org/W2090280626","https://openalex.org/W2132000251","https://openalex.org/W2140798038","https://openalex.org/W2148376557","https://openalex.org/W2318638346","https://openalex.org/W2342812949","https://openalex.org/W4233170031","https://openalex.org/W4317640862"],"related_works":["https://openalex.org/W2366414223","https://openalex.org/W1972163180","https://openalex.org/W2039376726","https://openalex.org/W2917303805","https://openalex.org/W2017605663","https://openalex.org/W2055359826","https://openalex.org/W2051894896","https://openalex.org/W6990387703","https://openalex.org/W2066171172","https://openalex.org/W2591991112"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}