{"id":"https://openalex.org/W2082301185","doi":"https://doi.org/10.1097/mnh.0b013e3281ca6ffd","title":"Emerging role of fibroblast growth factor 23 in a bone\u2013kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization","display_name":"Emerging role of fibroblast growth factor 23 in a bone\u2013kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization","publication_year":2007,"publication_date":"2007-06-12","ids":{"openalex":"https://openalex.org/W2082301185","doi":"https://doi.org/10.1097/mnh.0b013e3281ca6ffd","mag":"2082301185","pmid":"https://pubmed.ncbi.nlm.nih.gov/17565275"},"language":"en","primary_location":{"id":"doi:10.1097/mnh.0b013e3281ca6ffd","doi":"https://doi.org/10.1097/mnh.0b013e3281ca6ffd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mnh.0b013e3281ca6ffd","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology & Hypertension","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101552475","display_name":"Shiguang Liu","orcid":"https://orcid.org/0000-0003-0732-5230","observed_orcids":["https://orcid.org/0000-0003-0732-5230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiguang Liu","raw_affiliation_strings":["Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas 66160, USA","Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas 66160, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049059991","display_name":"Aditi Gupta","orcid":"https://orcid.org/0000-0002-6286-802X","observed_orcids":["https://orcid.org/0000-0002-6286-802X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aditi Gupta","raw_affiliation_strings":["Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028902678","display_name":"L. Darryl Quarles","orcid":"https://orcid.org/0000-0002-5082-7896","observed_orcids":["https://orcid.org/0000-0002-5082-7896"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"L Darryl Quarles","raw_affiliation_strings":["Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas, USA","to L. Darryl Quarles, MD, Summerfield Endowed Professor of Nephrology Vice Chairman, Department of Internal Medicine Director, The Kidney Institute and Division of Nephrology, MS 3018, 3901 Rainbow Boulevard, 6018 Wahl Hall, East Kansas City, KS 66160, USA Tel: +1 913 588 9255; fax: +1 913 588 9251; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","fax: +1 913 588 9251","to L. Darryl Quarles, MD, Summerfield Endowed Professor of Nephrology Vice Chairman, Department of Internal Medicine Director, The Kidney Institute and Division of Nephrology, MS 3018, 3901 Rainbow Boulevard, 6018 Wahl Hall, East Kansas City, KS 66160, USA Tel: +1 913 588 9255"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas, USA","institution_ids":[]},{"raw_affiliation_string":"to L. Darryl Quarles, MD, Summerfield Endowed Professor of Nephrology Vice Chairman, Department of Internal Medicine Director, The Kidney Institute and Division of Nephrology, MS 3018, 3901 Rainbow Boulevard, 6018 Wahl Hall, East Kansas City, KS 66160, USA Tel: +1 913 588 9255; fax: +1 913 588 9251; e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 913 588 9251","institution_ids":[]},{"raw_affiliation_string":"to L. Darryl Quarles, MD, Summerfield Endowed Professor of Nephrology Vice Chairman, Department of Internal Medicine Director, The Kidney Institute and Division of Nephrology, MS 3018, 3901 Rainbow Boulevard, 6018 Wahl Hall, East Kansas City, KS 66160, USA Tel: +1 913 588 9255","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028902678"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2802,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.91013384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"4","first_page":"329","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphate-homeostasis","display_name":"phosphate homeostasis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/extracellular-matrix-mineralization","display_name":"extracellular matrix mineralization","score":0.871999979019165},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.7580000162124634},{"id":"https://openalex.org/keywords/vitamin-d-metabolism","display_name":"vitamin D metabolism","score":0.8009999990463257},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.8009999990463257},{"id":"https://openalex.org/keywords/phosphate-reabsorption","display_name":"phosphate reabsorption","score":0.7929999828338623},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.765999972820282},{"id":"https://openalex.org/keywords/hypophosphatemic-rickets","display_name":"hypophosphatemic rickets","score":0.921999990940094},{"id":"https://openalex.org/keywords/osteomalacia","display_name":"osteomalacia","score":0.7319999933242798},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7559999823570251},{"id":"https://openalex.org/keywords/dmp1","display_name":"DMP1","score":0.7580000162124634},{"id":"https://openalex.org/keywords/phex","display_name":"PHEX","score":0.9629999995231628},{"id":"https://openalex.org/keywords/calcinosis","display_name":"calcinosis","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.8606200218200684},{"id":"https://openalex.org/C2776338720","wikidata":"https://www.wikidata.org/wiki/Q14913440","display_name":"PHEX","level":4,"score":0.7900643348693848},{"id":"https://openalex.org/C2778049618","wikidata":"https://www.wikidata.org/wiki/Q860395","display_name":"Osteomalacia","level":3,"score":0.7899543046951294},{"id":"https://openalex.org/C2911197707","wikidata":"https://www.wikidata.org/wiki/Q1779987","display_name":"Hypophosphatemic Rickets","level":4,"score":0.7563337087631226},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7530880570411682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7271904349327087},{"id":"https://openalex.org/C2778573388","wikidata":"https://www.wikidata.org/wiki/Q1641384","display_name":"Hypophosphatemia","level":2,"score":0.6618261933326721},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6419880986213684},{"id":"https://openalex.org/C2776036575","wikidata":"https://www.wikidata.org/wiki/Q1641062","display_name":"Hyperphosphatemia","level":3,"score":0.5844777822494507},{"id":"https://openalex.org/C2776489590","wikidata":"https://www.wikidata.org/wiki/Q183392","display_name":"Rickets","level":3,"score":0.5831567645072937},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.501737117767334},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.48503369092941284},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4818933606147766},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4577440619468689},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.4533015489578247},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.4134616553783417},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3887823224067688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3852596879005432},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2803746461868286},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.2320304811000824},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1267382800579071}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017674","descriptor_name":"Hypophosphatemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mnh.0b013e3281ca6ffd","doi":"https://doi.org/10.1097/mnh.0b013e3281ca6ffd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mnh.0b013e3281ca6ffd","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology & Hypertension","raw_type":"journal-article"},{"id":"pmid:17565275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17565275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in nephrology and hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5206617581","display_name":"Regulation and Function of FGF23","funder_award_id":"R56AR045955","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1563425273","https://openalex.org/W1967604492","https://openalex.org/W1968658067","https://openalex.org/W1968779137","https://openalex.org/W1973380233","https://openalex.org/W1979425916","https://openalex.org/W1994303022","https://openalex.org/W1996442598","https://openalex.org/W2002223230","https://openalex.org/W2002494594","https://openalex.org/W2003490678","https://openalex.org/W2005451176","https://openalex.org/W2008101181","https://openalex.org/W2011349880","https://openalex.org/W2016552469","https://openalex.org/W2017219647","https://openalex.org/W2019253822","https://openalex.org/W2021852822","https://openalex.org/W2030666947","https://openalex.org/W2035059755","https://openalex.org/W2035221187","https://openalex.org/W2037498463","https://openalex.org/W2038873692","https://openalex.org/W2051959338","https://openalex.org/W2054492217","https://openalex.org/W2055519810","https://openalex.org/W2058444029","https://openalex.org/W2059022155","https://openalex.org/W2059360654","https://openalex.org/W2060331245","https://openalex.org/W2063765502","https://openalex.org/W2066517300","https://openalex.org/W2067633248","https://openalex.org/W2068226571","https://openalex.org/W2068249054","https://openalex.org/W2070929800","https://openalex.org/W2078115324","https://openalex.org/W2079922348","https://openalex.org/W2080403445","https://openalex.org/W2082235998","https://openalex.org/W2083237361","https://openalex.org/W2088931725","https://openalex.org/W2090208385","https://openalex.org/W2091948921","https://openalex.org/W2092787493","https://openalex.org/W2099681379","https://openalex.org/W2105398326","https://openalex.org/W2107207648","https://openalex.org/W2108998830","https://openalex.org/W2109177164","https://openalex.org/W2113356410","https://openalex.org/W2114164409","https://openalex.org/W2114360920","https://openalex.org/W2114372930","https://openalex.org/W2115454272","https://openalex.org/W2122085108","https://openalex.org/W2128059069","https://openalex.org/W2129904461","https://openalex.org/W2131064361","https://openalex.org/W2144414222","https://openalex.org/W2152109784","https://openalex.org/W2158687094","https://openalex.org/W2159323221","https://openalex.org/W2164074621","https://openalex.org/W2164533721","https://openalex.org/W2164952534","https://openalex.org/W2167074133","https://openalex.org/W2167092665","https://openalex.org/W2169170480","https://openalex.org/W2170092490","https://openalex.org/W2170351820","https://openalex.org/W2170890561","https://openalex.org/W2171100097","https://openalex.org/W2172200321","https://openalex.org/W2340341894","https://openalex.org/W2344784533"],"related_works":["https://openalex.org/W2125079553","https://openalex.org/W2166377418","https://openalex.org/W188132638","https://openalex.org/W1674343883","https://openalex.org/W2089679951","https://openalex.org/W2168322307","https://openalex.org/W53850004","https://openalex.org/W2066512796","https://openalex.org/W7100621459","https://openalex.org/W2321087198"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"To":[3],"describe":[4],"emerging":[5],"understanding":[6],"of":[7,109,193],"fibroblast":[8],"growth":[9],"factor":[10,32,49],"23":[11],"(FGF23)":[12],"-":[13],"a":[14,34,66],"bone-derived":[15],"hormone":[16,69,93],"that":[17],"inhibits":[18,55],"phosphate":[19,39,56,76,176],"reabsorption":[20,57],"and":[21,26,41,58,73,94,114,121,137,161,174,186],"calcitriol":[22],"production":[23,60],"by":[24,51,61],"kidney":[25],"participates":[27],"as":[28],"the":[29],"principle":[30],"phosphaturic":[31,68],"in":[33,53,144,183],"bone-kidney":[35],"axis":[36],"coordinating":[37],"systemic":[38,75],"homeostasis":[40,77],"bone":[42,166],"mineralization.":[43,80],"RECENT":[44],"FINDINGS:":[45],"FGF23":[46,64,84,96,127,130,140,154,178,194],"(a":[47],"circulating":[48,83],"made":[50],"osteocytes":[52],"bone)":[54],"1,25(OH)2D":[59,89],"kidney.":[62],"Physiologically,":[63],"is":[65,141],"counter-regulatory":[67],"for":[70,189],"vitamin":[71,168],"D":[72,169],"coordinates":[74],"with":[78],"skeletal":[79],"Pathologically,":[81],"high":[82],"levels":[85,131,195],"cause":[86,101,116],"hypophosphatemia,":[87],"decreased":[88],"production,":[90],"elevated":[91,135],"parathyroid":[92,171],"rickets/osteomalacia.":[95],"mutations":[97,108],"impairing":[98],"its":[99,149],"degradation":[100],"autosomal":[102,117],"dominant":[103],"hypophosphatemic":[104,119,123,185],"rickets.":[105],"Respective":[106],"loss-of-function":[107],"osteocyte":[110],"gene":[111],"products":[112],"DMP1":[113],"Phex":[115],"recessive":[118],"rickets":[120],"X-linked":[122],"rickets,":[124],"initiating":[125],"increased":[126,143],"production.":[128],"Low":[129],"lead":[132],"to":[133],"hyperphosphatemia,":[134],"1,25(OH)2D,":[136],"soft-tissue":[138],"calcifications.":[139],"markedly":[142],"chronic":[145],"renal":[146,175],"disease,":[147],"but":[148],"role":[150],"remains":[151],"undefined.":[152],"SUMMARY:":[153],"discovery":[155],"has":[156],"uncovered":[157],"primary":[158],"regulatory":[159],"pathways":[160],"new":[162],"systems":[163],"biology":[164],"governing":[165],"mineralization,":[167],"metabolism,":[170],"gland":[172],"function,":[173],"handling.":[177],"assessment":[179],"will":[180],"become":[181],"important":[182],"diagnosing":[184],"hyperphosphatemic":[187],"disorders,":[188],"which":[190],"pharmacological":[191],"regulation":[192],"may":[196],"provide":[197],"novel":[198],"treatments.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}