{"id":"https://openalex.org/W2082295803","doi":"https://doi.org/10.1371/journal.ppat.1004642","title":"Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice","display_name":"Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice","publication_year":2015,"publication_date":"2015-02-10","ids":{"openalex":"https://openalex.org/W2082295803","doi":"https://doi.org/10.1371/journal.ppat.1004642","mag":"2082295803","pmid":"https://pubmed.ncbi.nlm.nih.gov/25668410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4335497"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1004642","doi":"https://doi.org/10.1371/journal.ppat.1004642","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004642","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004642&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004642&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009623128","display_name":"Susu Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susu Duan","raw_affiliation_strings":["Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024330605","display_name":"Victoria Meliopoulos","orcid":"https://orcid.org/0000-0003-1442-9177","observed_orcids":["https://orcid.org/0000-0003-1442-9177"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria A. Meliopoulos","raw_affiliation_strings":["Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060954798","display_name":"Jennifer L. McClaren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. McClaren","raw_affiliation_strings":["Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030968735","display_name":"Xi-zhi J. Guo","orcid":"https://orcid.org/0000-0002-5564-3287","observed_orcids":["https://orcid.org/0000-0002-5564-3287"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi-Zhi J. Guo","raw_affiliation_strings":["Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061855492","display_name":"Catherine J. Sanders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine J. Sanders","raw_affiliation_strings":["Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053781567","display_name":"Heather S. Smallwood","orcid":"https://orcid.org/0000-0001-5711-5771","observed_orcids":["https://orcid.org/0000-0001-5711-5771","https://orcid.org/0000-0001-8278-8118"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather S. Smallwood","raw_affiliation_strings":["Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005839226","display_name":"Richard J. Webby","orcid":"https://orcid.org/0000-0002-4397-7132","observed_orcids":["https://orcid.org/0000-0002-4397-7132"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Webby","raw_affiliation_strings":["Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088615597","display_name":"Stacey Schultz\u2010Cherry","orcid":"https://orcid.org/0000-0002-2021-727X","observed_orcids":["https://orcid.org/0000-0002-2021-727X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey L. Schultz-Cherry","raw_affiliation_strings":["Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074692390","display_name":"Peter C. Doherty","orcid":"https://orcid.org/0000-0002-5028-3489","observed_orcids":["https://orcid.org/0000-0002-5028-3489","https://orcid.org/0000-0001-6863-0533"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter C. Doherty","raw_affiliation_strings":["Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005724506","display_name":"Paul Glyndwr Thomas","orcid":"https://orcid.org/0000-0001-7955-0256","observed_orcids":["https://orcid.org/0000-0001-7955-0256"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul G. Thomas","raw_affiliation_strings":["Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005724506"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.5805,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8873466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"2","first_page":"e1004642","last_page":"e1004642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h7n9-influenza-virus","display_name":"H7N9 influenza virus","score":0.9430000185966492},{"id":"https://openalex.org/keywords/heterosubtypic-immunity","display_name":"heterosubtypic immunity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/immunodominance-hierarchy","display_name":"immunodominance hierarchy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cytotoxic-cd8-t-cells","display_name":"CD8+ cytotoxic T lymphocytes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cross-reactive-epitopes","display_name":"cross-reactive epitopes","score":0.8240000009536743},{"id":"https://openalex.org/keywords/h9n2-influenza","display_name":"H9N2 influenza","score":0.7950000166893005},{"id":"https://openalex.org/keywords/h1n1-influenza","display_name":"H1N1 influenza","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epitope-conservation","display_name":"epitope conservation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.48899999260902405},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2776525413","wikidata":"https://www.wikidata.org/wiki/Q17149888","display_name":"Immunodominance","level":4,"score":0.9157514572143555},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.7148959636688232},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.673262357711792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6702684164047241},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5915891528129578},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5766867995262146},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5441915988922119},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.5111454129219055},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.45269495248794556},{"id":"https://openalex.org/C2778886782","wikidata":"https://www.wikidata.org/wiki/Q536541","display_name":"Subdominant","level":4,"score":0.4499666094779968},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.4142098128795624},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.39258652925491333},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.29967188835144043},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2951071262359619},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1769150197505951},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0916721522808075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016056","descriptor_name":"Immunodominant Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064766","descriptor_name":"Influenza A Virus, H7N9 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D064789","descriptor_name":"Immunity, Heterologous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1004642","doi":"https://doi.org/10.1371/journal.ppat.1004642","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004642","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004642&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3315428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4335497","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4335497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4335497","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:25668410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25668410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.769.3022","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.769.3022","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ee/f5/ppat.1004642.PMC4335497.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5588ffd71821403d9c3f2a7168f990b7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5588ffd71821403d9c3f2a7168f990b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 11, Iss 2, p e1004642 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1305297","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Diverse_Heterologous_Primary_Infections_Radically_Alter_Immunodominance_Hierarchies_and_Clinical_Outcomes_Following_H7N9_Influenza_Challenge_in_Mice_/1305297","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/263453","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/263453","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1004642","doi":"https://doi.org/10.1371/journal.ppat.1004642","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004642","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004642&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1309367075","display_name":null,"funder_award_id":"HHSN266200700005C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5034719483","display_name":null,"funder_award_id":"HHSN266200700005C","funder_id":"https://openalex.org/F4320313598","funder_display_name":"American Lebanese Syrian Associated Charities"},{"id":"https://openalex.org/G5663772383","display_name":null,"funder_award_id":"HHSN266200700005C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8019673204","display_name":"Mechanisms to diversify repertoire and modify T cell activity after infection","funder_award_id":"R01AI107625","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G83230922","display_name":null,"funder_award_id":"HHSN26620 0700005C","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082295803.pdf","grobid_xml":"https://content.openalex.org/works/W2082295803.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W65101360","https://openalex.org/W1502658357","https://openalex.org/W1531797215","https://openalex.org/W1631517993","https://openalex.org/W1761998434","https://openalex.org/W1922769964","https://openalex.org/W1930008246","https://openalex.org/W1932370258","https://openalex.org/W1962164504","https://openalex.org/W1969475094","https://openalex.org/W1971279413","https://openalex.org/W1972940706","https://openalex.org/W1973223290","https://openalex.org/W1977906296","https://openalex.org/W1987938089","https://openalex.org/W2000866311","https://openalex.org/W2004396083","https://openalex.org/W2005362030","https://openalex.org/W2005855529","https://openalex.org/W2006200047","https://openalex.org/W2010213883","https://openalex.org/W2018424830","https://openalex.org/W2020520306","https://openalex.org/W2024362275","https://openalex.org/W2027579505","https://openalex.org/W2028200050","https://openalex.org/W2035546162","https://openalex.org/W2037707118","https://openalex.org/W2041112838","https://openalex.org/W2041319603","https://openalex.org/W2042301753","https://openalex.org/W2044489248","https://openalex.org/W2045024225","https://openalex.org/W2053746900","https://openalex.org/W2054801694","https://openalex.org/W2059550296","https://openalex.org/W2060660461","https://openalex.org/W2076787697","https://openalex.org/W2079946290","https://openalex.org/W2085229531","https://openalex.org/W2089532164","https://openalex.org/W2093172753","https://openalex.org/W2095736835","https://openalex.org/W2097398162","https://openalex.org/W2105226322","https://openalex.org/W2106173155","https://openalex.org/W2106535354","https://openalex.org/W2106802277","https://openalex.org/W2109916423","https://openalex.org/W2114363915","https://openalex.org/W2120333986","https://openalex.org/W2121329353","https://openalex.org/W2126832747","https://openalex.org/W2130961724","https://openalex.org/W2134787952","https://openalex.org/W2137953161","https://openalex.org/W2139413077","https://openalex.org/W2142098856","https://openalex.org/W2146937472","https://openalex.org/W2148275137","https://openalex.org/W2155104070","https://openalex.org/W2157423609","https://openalex.org/W2159340685","https://openalex.org/W2168971343","https://openalex.org/W2169279776","https://openalex.org/W2318325499","https://openalex.org/W2415913335","https://openalex.org/W2417929263","https://openalex.org/W2422002828","https://openalex.org/W2893764973"],"related_works":["https://openalex.org/W7095090608","https://openalex.org/W4313385915","https://openalex.org/W2020292737","https://openalex.org/W7095402040","https://openalex.org/W1512426390","https://openalex.org/W2054801694","https://openalex.org/W1987938089","https://openalex.org/W1182118050","https://openalex.org/W4290975437","https://openalex.org/W2126833441"],"abstract_inverted_index":{"The":[0,23],"recent":[1],"emergence":[2],"of":[3,25,38,96,107,144,183,195,201,211,232,243,252,256,273],"a":[4,20,192,259],"novel":[5],"H7N9":[6,51,89,114,159],"influenza":[7],"A":[8],"virus":[9,78,226],"(IAV)":[10],"causing":[11],"severe":[12],"human":[13,266],"infections":[14,69],"in":[15,29,84,165],"China":[16],"raises":[17],"concerns":[18],"about":[19],"possible":[21],"pandemic.":[22],"lack":[24],"pre-existing":[26],"neutralizing":[27],"antibodies":[28],"the":[30,34,57,60,88,94,110,120,134,142,151,157,166,169,180,184,199,209,212,229,240,253,257,270],"broader":[31],"population":[32],"highlights":[33],"potential":[35],"protective":[36,220,241],"role":[37,231],"IAV-specific":[39,185],"CD8(+)":[40],"cytotoxic":[41],"T":[42],"lymphocyte":[43],"(CTL)":[44],"memory":[45,99,186,213],"specific":[46],"for":[47,133,264],"epitopes":[48,149],"conserved":[49,111],"between":[50,150],"and":[52,75,80,138,154,156,246,269],"previously":[53],"encountered":[54],"IAVs.":[55],"In":[56,91],"present":[58],"study,":[59],"heterosubtypic":[61,244],"immunity":[62,245],"generated":[63],"by":[64,102,127],"prior":[65],"H9N2":[66,153],"or":[67,112,147,204,225],"H1N1":[68,155],"significantly,":[70],"but":[71],"variably,":[72],"reduced":[73],"morbidity":[74],"mortality,":[76],"pulmonary":[77],"load":[79],"time":[81],"to":[82,176],"clearance":[83],"mice":[85],"challenged":[86],"with":[87],"virus.":[90],"all":[92],"cases,":[93],"recall":[95],"established":[97],"CTL":[98,129,187,206,214,247,267],"was":[100,125,191],"characterized":[101],"earlier,":[103],"greater":[104],"airway":[105],"infiltration":[106],"effectors":[108],"targeting":[109],"cross-reactive":[113,148],"IAV":[115],"peptides;":[116],"though,":[117],"depending":[118],"on":[119,222],"priming":[121,152,190],"IAV,":[122],"each":[123],"case":[124],"accompanied":[126],"distinct":[128],"epitope":[130,177,202],"immunodominance":[131,167,248],"hierarchies":[132,249],"prominent":[135],"K(b)PB(1703,":[136],"D(b)PA(224),":[137],"D(b)NP(366)":[139],"epitopes.":[140],"While":[141],"presence":[143],"conserved,":[145],"variable,":[146],"challenge":[158],"IAVs":[160],"clearly":[161],"influenced":[162],"any":[163],"change":[164],"hierarchy,":[168],"changing":[170],"patterns":[171],"were":[172],"not":[173],"tied":[174],"solely":[175],"conservation.":[178],"Furthermore,":[179],"total":[181],"size":[182,210],"pool":[188,215],"after":[189],"better":[193],"predictor":[194],"favorable":[196],"outcomes":[197],"than":[198],"extent":[200],"conservation":[203],"secondary":[205],"expansion.":[207],"Modifying":[208],"significantly":[216],"altered":[217],"its":[218],"subsequent":[219],"efficacy":[221,242],"disease":[223],"severity":[224],"clearance,":[227],"confirming":[228],"important":[230],"heterologous":[233],"priming.":[234],"These":[235],"findings":[236],"establish":[237],"that":[238,261],"both":[239],"are":[250],"reflective":[251],"immunological":[254],"history":[255],"host,":[258],"finding":[260],"has":[262],"implications":[263],"understanding":[265],"responses":[268],"rational":[271],"design":[272],"CTL-mediated":[274],"vaccines.":[275]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
