{"id":"https://openalex.org/W2082258689","doi":"https://doi.org/10.1161/01.cir.94.10.2497","title":"Single-Beat Estimation of End-Systolic Pressure-Volume Relation in Humans: A New Method With the Potential for Noninvasive Application","display_name":"Single-Beat Estimation of End-Systolic Pressure-Volume Relation in Humans: A New Method With the Potential for Noninvasive Application","publication_year":1996,"publication_date":"1996-11-15","ids":{"openalex":"https://openalex.org/W2082258689","doi":"https://doi.org/10.1161/01.cir.94.10.2497","mag":"2082258689","pmid":"https://pubmed.ncbi.nlm.nih.gov/8921794"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.94.10.2497","doi":"https://doi.org/10.1161/01.cir.94.10.2497","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.94.10.2497","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2082258689"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001804602","display_name":"Hideaki Senzaki","orcid":"https://orcid.org/0000-0002-8289-0953","observed_orcids":["https://orcid.org/0000-0002-8289-0953"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hideaki Senzaki","raw_affiliation_strings":["the Division of Cardiology, Department of Internal Medicine, Johns Hopkins University Medical Institutions, Baltimore, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Cardiology, Department of Internal Medicine, Johns Hopkins University Medical Institutions, Baltimore, Md","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113852844","display_name":"Chen-Huan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen-Huan Chen","raw_affiliation_strings":["the Division of Cardiology, Department of Internal Medicine, Johns Hopkins University Medical Institutions, Baltimore, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Cardiology, Department of Internal Medicine, Johns Hopkins University Medical Institutions, Baltimore, Md","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081031540","display_name":"David A. Kass","orcid":"https://orcid.org/0000-0003-1596-2299","observed_orcids":["https://orcid.org/0000-0003-1596-2299","https://orcid.org/0000-0002-5286-6506"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Kass","raw_affiliation_strings":["the Division of Cardiology, Department of Internal Medicine, Johns Hopkins University Medical Institutions, Baltimore, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Cardiology, Department of Internal Medicine, Johns Hopkins University Medical Institutions, Baltimore, Md","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9242,"has_fulltext":false,"cited_by_count":397,"citation_normalized_percentile":{"value":0.91601782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"94","issue":"10","first_page":"2497","last_page":"2506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/end-systolic-pressure-volume-relationship","display_name":"end-systolic pressure-volume relationship","score":0.9929999709129333},{"id":"https://openalex.org/keywords/time-varying-elastance","display_name":"time-varying elastance","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pressure-volume-loops","display_name":"pressure-volume loops","score":0.6959999799728394},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.7289999723434448},{"id":"https://openalex.org/keywords/noninvasive-cardiac-function-assessment","display_name":"noninvasive cardiac function assessment","score":0.7490000128746033},{"id":"https://openalex.org/keywords/conductance-catheter","display_name":"conductance catheter","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8506589531898499},{"id":"https://openalex.org/C189809214","wikidata":"https://www.wikidata.org/wiki/Q829522","display_name":"Beat (acoustics)","level":2,"score":0.7002970576286316},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5700868368148804},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5151833295822144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.444386750459671},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.41345033049583435},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.08760941028594971},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002309","descriptor_name":"Cardiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.94.10.2497","doi":"https://doi.org/10.1161/01.cir.94.10.2497","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.94.10.2497","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:8921794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8921794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3937191488","display_name":"VENTRICULAR VASCULAR STIFFENING IN ELDERLY HUMANS","funder_award_id":"R01AG012249","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W199479987","https://openalex.org/W202268125","https://openalex.org/W1792854258","https://openalex.org/W1963721828","https://openalex.org/W1963771304","https://openalex.org/W1964981214","https://openalex.org/W1970961862","https://openalex.org/W1978029812","https://openalex.org/W1980381547","https://openalex.org/W1989106589","https://openalex.org/W1996288114","https://openalex.org/W2005975853","https://openalex.org/W2006460754","https://openalex.org/W2011154463","https://openalex.org/W2016754953","https://openalex.org/W2017670551","https://openalex.org/W2025848052","https://openalex.org/W2062096995","https://openalex.org/W2077114187","https://openalex.org/W2082543306","https://openalex.org/W2097364562","https://openalex.org/W2098353249","https://openalex.org/W2107928624","https://openalex.org/W2118488318","https://openalex.org/W2119229486","https://openalex.org/W2145950740","https://openalex.org/W2150390872","https://openalex.org/W2162282723","https://openalex.org/W2165770561","https://openalex.org/W2166303436","https://openalex.org/W2179736300","https://openalex.org/W2219301210","https://openalex.org/W2249484095","https://openalex.org/W2277595176"],"related_works":["https://openalex.org/W2011154463","https://openalex.org/W4416614782","https://openalex.org/W2107836188","https://openalex.org/W2060289016","https://openalex.org/W2126813003","https://openalex.org/W2947123392","https://openalex.org/W7154468655","https://openalex.org/W4415589478","https://openalex.org/W1987613101"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,87,201],"end-systolic":[2],"pressure-volume":[3],"relation":[4],"(ESPVR)":[5],"provides":[6],"a":[7,32,232,237],"useful":[8],"measure":[9],"of":[10,115,120,139],"contractile":[11],"function.":[12],"However,":[13],"the":[14,110,118,137],"need":[15],"to":[16,84,113,151,216],"acquire":[17],"multiple":[18],"cardiac":[19,98,229],"cycles":[20,230],"at":[21,143],"varying":[22],"loads":[23],"limits":[24],"its":[25],"applicability.":[26],"We":[27],"therefore":[28],"developed":[29],"and":[30,77,82,102,123,127,147,164,195,213],"tested":[31],"novel":[33],"single-beat":[34],"estimation":[35,203],"method":[36,204,234],"that":[37,235],"is":[38],"based":[39],"on":[40],"normalized":[41,78,144],"human":[42],"time-varying":[43],"elastance":[44,67],"curves":[45,68,90],"[EN(tN)].":[46],"METHODS":[47],"AND":[48],"RESULTS:":[49],"Pressure-volume":[50],"(PV)":[51],"data":[52,141,184],"were":[53,69,91,131,171],"measured":[54,142,175,207],"by":[55,80,179,199,231],"conductance":[56],"catheter":[57],"in":[58,96,225],"87":[59],"patients":[60],"with":[61,105,136,174],"normal":[62],"or":[63],"myopathic":[64],"hearts.":[65],"Time-varying":[66],"generated":[70],"from":[71,133,185,227],"72":[72],"PV":[73,140],"loops":[74],"(52":[75],"patients)":[76],"both":[79],"amplitude":[81],"time":[83,145],"peak":[85],"amplitude.":[86],"resulting":[88],"EN(tN)":[89],"remarkably":[92],"consistent":[93],"despite":[94],"variations":[95],"underlying":[97],"disease,":[99],"contractility,":[100],"loading,":[101],"heart":[103],"rate,":[104],"minimal":[106],"interloop":[107],"variance":[108],"during":[109],"first":[111],"25%":[112],"35%":[114],"contraction.":[116],"On":[117],"basis":[119],"this":[121],"finding":[122],"assuming":[124],"ESPVR":[125,176],"linearity":[126],"constant":[128],"volume-intercept,":[129],"ESPVRs":[130,208,220],"estimated":[132,224],"one":[134],"beat":[135],"use":[138],"(tN)":[146],"end":[148],"systole":[149],"(tmax)":[150],"predict":[152],"intercept:":[153],"Vo(SB)":[154],"=":[155,167],"[EN(tN)":[156],"x":[157,159,162],"P(tmax)":[158],"V(tN)-P(tN)x":[160],"V(tmax)]/[EN(tN)":[161],"P(tmax)-P(tN)]":[163],"slope":[165],"Emax(SB)":[166,189],"Pes/[Ves-Vo(SB)].":[168],"Single-beat":[169],"estimates":[170],"highly":[172],"correlated":[173],"values":[177],"obtained":[178],"standard":[180],"multiple-beat":[181],"analysis":[182],"(including":[183],"35":[186],"additional":[187],"patients).":[188],"accurately":[190],"reflected":[191],"acute":[192],"inotropic":[193],"change":[194],"was":[196,214],"influenced":[197],"little":[198],"loading.":[200],"new":[202,233],"also":[205],"predicted":[206],"better":[209],"than":[210],"prior":[211],"techniques":[212],"applicable":[215],"noninvasive":[217,240],"analysis.":[218],"CONCLUSIONS:":[219],"can":[221],"be":[222],"reliably":[223],"humans":[226],"single":[228],"has":[236],"potential":[238],"for":[239],"application.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
