{"id":"https://openalex.org/W2082229472","doi":"https://doi.org/10.1371/journal.pone.0001009","title":"Effect of Differential N-linked and O-linked Mannosylation on Recognition of Fungal Antigens by Dendritic Cells","display_name":"Effect of Differential N-linked and O-linked Mannosylation on Recognition of Fungal Antigens by Dendritic Cells","publication_year":2007,"publication_date":"2007-10-10","ids":{"openalex":"https://openalex.org/W2082229472","doi":"https://doi.org/10.1371/journal.pone.0001009","mag":"2082229472","pmid":"https://pubmed.ncbi.nlm.nih.gov/17925857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1995759"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0001009","doi":"https://doi.org/10.1371/journal.pone.0001009","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001009","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001009&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001009&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076921042","display_name":"Jennifer S. Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer S. Lam","raw_affiliation_strings":["Department of Medicine and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America","Department of Microbiology and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Microbiology and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057980496","display_name":"Haibin Huang","orcid":"https://orcid.org/0000-0002-8357-432X","observed_orcids":["https://orcid.org/0000-0002-8357-432X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haibin Huang","raw_affiliation_strings":["Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054141043","display_name":"Stuart M. Levitz","orcid":"https://orcid.org/0000-0002-3799-3064","observed_orcids":["https://orcid.org/0000-0002-3799-3064"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart M. Levitz","raw_affiliation_strings":["Department of Medicine and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America","Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America","Department of Microbiology and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Microbiology and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054141043"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I166722992"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.916,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.86102719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"10","first_page":"e1009","last_page":"e1009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.859000027179718},{"id":"https://openalex.org/keywords/dc-sign","display_name":"DC-SIGN","score":0.8519999980926514},{"id":"https://openalex.org/keywords/c-type-lectin-receptors","display_name":"C-type lectin receptors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/antigen-uptake","display_name":"antigen uptake","score":0.9240000247955322},{"id":"https://openalex.org/keywords/deglycosylation","display_name":"deglycosylation","score":0.722000002861023},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.6520000100135803},{"id":"https://openalex.org/keywords/yeast-mannan","display_name":"yeast mannan","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.6399487853050232},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6123551726341248},{"id":"https://openalex.org/C2776205754","wikidata":"https://www.wikidata.org/wiki/Q6750945","display_name":"Mannose receptor","level":4,"score":0.5904462337493896},{"id":"https://openalex.org/C2781372317","wikidata":"https://www.wikidata.org/wiki/Q148697","display_name":"Pichia pastoris","level":4,"score":0.569157063961029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5687171220779419},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.550133466720581},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5340643525123596},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5011940002441406},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4356110095977783},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42248275876045227},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.3714104890823364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3359867334365845},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21648788452148438},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1388651430606842},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06225404143333435}],"mesh":[{"descriptor_ui":"D000090323","descriptor_name":"Mannose Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099215","descriptor_name":"DC-Specific ICAM-3 Grabbing Nonintegrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000946","descriptor_name":"Antigens, Fungal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010843","descriptor_name":"Pichia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037241","descriptor_name":"Mannose-Binding Lectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0001009","doi":"https://doi.org/10.1371/journal.pone.0001009","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001009","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001009&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1995759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1995759","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:17925857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17925857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.1968","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.1968","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/21/f3/PLoS_ONE_2007_Oct_10_2(10)_e1009.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:77c62d1fcacc4a8abc89a8ed4aff8c58","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/77c62d1fcacc4a8abc89a8ed4aff8c58","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 2, Iss 10, p e1009 (2007)","raw_type":"article"},{"id":"pmh:oai:open.bu.edu:2144/2967","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2144/2967","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0001009","doi":"https://doi.org/10.1371/journal.pone.0001009","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001009","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001009&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3914007643","display_name":"Immune Response to Cryptococcal Infections","funder_award_id":"R01AI025780","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5900432282","display_name":"MACROPHAGE INTERACTIONS WITH C. NEOFORMANS","funder_award_id":"R01AI037532","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6686504093","display_name":"Model Vaccines Exploiting Fungal Mannosylation","funder_award_id":"R01AI066087","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082229472.pdf","grobid_xml":"https://content.openalex.org/works/W2082229472.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1568922103","https://openalex.org/W1579143707","https://openalex.org/W1582357464","https://openalex.org/W1661544713","https://openalex.org/W1938359025","https://openalex.org/W1975456619","https://openalex.org/W1976925504","https://openalex.org/W1988940275","https://openalex.org/W1994282287","https://openalex.org/W1996242613","https://openalex.org/W1998733027","https://openalex.org/W2003042213","https://openalex.org/W2013686456","https://openalex.org/W2017758723","https://openalex.org/W2018840987","https://openalex.org/W2020871710","https://openalex.org/W2031280438","https://openalex.org/W2050520863","https://openalex.org/W2082194217","https://openalex.org/W2087166273","https://openalex.org/W2087181772","https://openalex.org/W2092235636","https://openalex.org/W2094854776","https://openalex.org/W2111695773","https://openalex.org/W2118111782","https://openalex.org/W2120095412","https://openalex.org/W2124270882","https://openalex.org/W2127404676","https://openalex.org/W2133449490","https://openalex.org/W2135079499","https://openalex.org/W2140734388","https://openalex.org/W2144514674","https://openalex.org/W2177327503"],"related_works":["https://openalex.org/W7100152043","https://openalex.org/W2462089688","https://openalex.org/W7851764","https://openalex.org/W2144514674","https://openalex.org/W2082194217","https://openalex.org/W2768240697","https://openalex.org/W2020164739","https://openalex.org/W2011111506","https://openalex.org/W2149464876","https://openalex.org/W2238732074"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"experimental":[2],"approach":[3],"for":[4,51,75,192,205],"improving":[5],"vaccine":[6,206],"efficacy":[7],"involves":[8],"targeting":[9],"antigens":[10,94,101,126,131],"to":[11,38,44,210,220],"mannose":[12,78],"receptors":[13,186],"(MRs)":[14],"on":[15],"dendritic":[16],"cells":[17],"(DCs)":[18],"and":[19,64,82,135,143,155,208],"other":[20],"professional":[21],"antigen":[22],"presenting":[23],"cells.":[24],"Previously,":[25],"we":[26],"demonstrated":[27],"that":[28,152,179],"mannosylated":[29,63,100,154,198],"Pichia":[30],"pastoris-derived":[31,158],"recombinant":[32,66,159],"proteins":[33,39,160],"exhibited":[34],"increased":[35,180],"immunogenicity":[36],"compared":[37],"lacking":[40],"mannosylation.":[41],"In":[42,129],"order":[43],"gain":[45],"insight":[46],"into":[47,102],"the":[48,54,58,62,76,86,89,122,140,188,193,217],"mechanisms":[49],"responsible":[50,191],"this":[52],"observation,":[53],"present":[55],"study":[56],"examined":[57],"cellular":[59],"uptake":[60,98,123,144,181],"of":[61,88,99,124,213],"deglycosylated":[65,125,156],"proteins.":[67,199],"METHODOLOGY/PRINCIPAL":[68],"FINDINGS:":[69],"Utilizing":[70],"transfected":[71],"cell":[72],"lines,":[73],"roles":[74],"macrophage":[77],"receptor":[79],"(MMR,":[80],"CD206)":[81],"DC-SIGN":[83],"(CD209)":[84],"in":[85,162],"recognition":[87],"mannosylated,":[90],"but":[91],"not":[92],"deglycosylated,":[93],"were":[95],"demonstrated.":[96],"The":[97],"murine":[103],"bone":[104],"marrow-derived":[105],"DCs":[106],"(BMDCs)":[107],"was":[108],"inhibited":[109],"by":[110,145,182],"yeast":[111],"mannans":[112],"(YMs),":[113],"suggesting":[114],"a":[115],"mannose-specific":[116,183],"C-type":[117,184],"lectin":[118,185],"receptor-dependent":[119],"process,":[120],"while":[121],"remained":[127],"unaffected.":[128],"particular,":[130],"with":[132,172,197],"both":[133,153],"N-linked":[134],"extensive":[136],"O-linked":[137],"mannosylation":[138],"showed":[139],"highest":[141],"binding":[142],"BMDCs.":[146,168],"Finally,":[147],"confocal":[148],"microscopy":[149],"studies":[150],"revealed":[151],"P.":[157],"localized":[161],"MHC":[163],"class":[164],"II+":[165],"compartments":[166],"within":[167],"CONCLUSIONS/SIGNIFICANCE:":[169],"Taken":[170],"together":[171],"our":[173,211],"previous":[174],"results,":[175],"these":[176],"data":[177],"suggest":[178],"is":[187],"major":[189],"mechanism":[190],"enhanced":[194],"antigenicity":[195],"seen":[196],"These":[200],"findings":[201],"have":[202],"important":[203],"implications":[204],"design":[207],"contribute":[209],"understanding":[212],"how":[214],"glycosylation":[215],"affects":[216],"immune":[218],"response":[219],"eukaryotic":[221],"pathogens.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
