{"id":"https://openalex.org/W2082215822","doi":"https://doi.org/10.1016/0008-8749(91)90156-6","title":"In vitro and in vivo immunosuppressive effects of supernatants from human choriocarcinoma cell lines","display_name":"In vitro and in vivo immunosuppressive effects of supernatants from human choriocarcinoma cell lines","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W2082215822","doi":"https://doi.org/10.1016/0008-8749(91)90156-6","mag":"2082215822","pmid":"https://pubmed.ncbi.nlm.nih.gov/1834345"},"language":"en","primary_location":{"id":"doi:10.1016/0008-8749(91)90156-6","doi":"https://doi.org/10.1016/0008-8749(91)90156-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0008-8749(91)90156-6","pdf_url":null,"source":{"id":"https://openalex.org/S193466101","display_name":"Cellular Immunology","issn_l":"0008-8749","issn":["0008-8749","1090-2163"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101656908","display_name":"Lakshmi Krishnan","orcid":"https://orcid.org/0000-0002-4122-6335","observed_orcids":["https://orcid.org/0000-0002-4122-6335"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Lakshmi Krishnan","raw_affiliation_strings":["National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063721175","display_name":"Elisabeth Menu","orcid":"https://orcid.org/0000-0001-8844-9328","observed_orcids":["https://orcid.org/0000-0001-8844-9328"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisabeth Menu","raw_affiliation_strings":["INSERM U262, Clinique Universitaire Baudelocque, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U262, Clinique Universitaire Baudelocque, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112510564","display_name":"G\u00e9rard Chaouat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gerard Chaouat","raw_affiliation_strings":["INSERM U262, Clinique Universitaire Baudelocque, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U262, Clinique Universitaire Baudelocque, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112179227","display_name":"G. P. Talwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G.P. Talwar","raw_affiliation_strings":["National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035202034","display_name":"Raj Raghupathy","orcid":"https://orcid.org/0000-0002-7925-864X","observed_orcids":["https://orcid.org/0000-0002-7925-864X"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Raj Raghupathy","raw_affiliation_strings":["National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.5116,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.63675114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"138","issue":"2","first_page":"313","last_page":"325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choriocarcinoma","display_name":"choriocarcinoma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9449999928474426},{"id":"https://openalex.org/keywords/suppressor-factor","display_name":"suppressor factor","score":0.7519999742507935},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7300000190734863},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.8399999737739563},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/allogeneic-immune-response","display_name":"allogeneic response","score":0.8740000128746033},{"id":"https://openalex.org/keywords/maternal-fetal-immune-tolerance","display_name":"maternal-fetal immune tolerance","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mitogen-induced-proliferation","display_name":"mitogen-induced proliferation","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7677699327468872},{"id":"https://openalex.org/C2780832733","wikidata":"https://www.wikidata.org/wiki/Q1076481","display_name":"Choriocarcinoma","level":2,"score":0.7270176410675049},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6887428164482117},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.613693118095398},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.6060067415237427},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5831495523452759},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.562371551990509},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5511007308959961},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47050994634628296},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.46017590165138245},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.41664227843284607},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3958991467952728},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.378434419631958},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07971987128257751},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0008-8749(91)90156-6","doi":"https://doi.org/10.1016/0008-8749(91)90156-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0008-8749(91)90156-6","pdf_url":null,"source":{"id":"https://openalex.org/S193466101","display_name":"Cellular Immunology","issn_l":"0008-8749","issn":["0008-8749","1090-2163"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Immunology","raw_type":"journal-article"},{"id":"pmid:1834345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1834345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.75}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1492216120","https://openalex.org/W1501872322","https://openalex.org/W1505245145","https://openalex.org/W1517843375","https://openalex.org/W1526539212","https://openalex.org/W1556106767","https://openalex.org/W1601530703","https://openalex.org/W1605454818","https://openalex.org/W1607028418","https://openalex.org/W1619281626","https://openalex.org/W1931351697","https://openalex.org/W1945160102","https://openalex.org/W1981079820","https://openalex.org/W1984670779","https://openalex.org/W2007391360","https://openalex.org/W2008734352","https://openalex.org/W2008950908","https://openalex.org/W2010399527","https://openalex.org/W2024057306","https://openalex.org/W2029715374","https://openalex.org/W2034402929","https://openalex.org/W2051885711","https://openalex.org/W2065236521","https://openalex.org/W2078802653","https://openalex.org/W2081477290","https://openalex.org/W2084900242","https://openalex.org/W2095170663","https://openalex.org/W2102194873","https://openalex.org/W2149421907","https://openalex.org/W2152298971","https://openalex.org/W2440213878"],"related_works":["https://openalex.org/W1994029971","https://openalex.org/W2138813699","https://openalex.org/W1965683566","https://openalex.org/W2034611367","https://openalex.org/W7132771239","https://openalex.org/W2117554734","https://openalex.org/W2008950908","https://openalex.org/W2403904310","https://openalex.org/W2044322289","https://openalex.org/W2078802653"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2016-06-24T00:00:00"}