{"id":"https://openalex.org/W2082210481","doi":"https://doi.org/10.1213/01.ane.0000243333.96141.40","title":"Glycopyrrolate Does Not Reduce the Incidence of Perioperative Adverse Events in Children with Upper Respiratory Tract Infections","display_name":"Glycopyrrolate Does Not Reduce the Incidence of Perioperative Adverse Events in Children with Upper Respiratory Tract Infections","publication_year":2007,"publication_date":"2007-01-19","ids":{"openalex":"https://openalex.org/W2082210481","doi":"https://doi.org/10.1213/01.ane.0000243333.96141.40","mag":"2082210481","pmid":"https://pubmed.ncbi.nlm.nih.gov/17242078"},"language":"en","primary_location":{"id":"doi:10.1213/01.ane.0000243333.96141.40","doi":"https://doi.org/10.1213/01.ane.0000243333.96141.40","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000243333.96141.40","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067341789","display_name":"Alan R. Tait","orcid":"https://orcid.org/0000-0002-0783-6084","observed_orcids":["https://orcid.org/0000-0002-0783-6084"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan R. Tait","raw_affiliation_strings":["Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA. atait@umich.edu","reprint requests to Alan R. Tait, PhD, Department of Anesthesiology, University of Michigan Health System, 1500 E. Medical Center Dr., Ann Arbor, MI 48109. Address e-mail to [email\u00a0protected]","the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA. atait@umich.edu","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"reprint requests to Alan R. Tait, PhD, Department of Anesthesiology, University of Michigan Health System, 1500 E. Medical Center Dr., Ann Arbor, MI 48109. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108964484","display_name":"Constance N. Burke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constance Burke","raw_affiliation_strings":["the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001739052","display_name":"Terri Voepel\u2010Lewis","orcid":"https://orcid.org/0000-0001-9718-9695","observed_orcids":["https://orcid.org/0000-0001-9718-9695"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terri Voepel-Lewis","raw_affiliation_strings":["the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Devi Chiravuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devi Chiravuri","raw_affiliation_strings":["the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061044678","display_name":"DEBORAH S. WAGNER","orcid":"https://orcid.org/0000-0002-5508-5676","observed_orcids":["https://orcid.org/0000-0002-5508-5676"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Wagner","raw_affiliation_strings":["the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031254556","display_name":"Shobha V. Malviya","orcid":"https://orcid.org/0000-0003-2046-6820","observed_orcids":["https://orcid.org/0000-0003-2046-6820"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shobha Malviya","raw_affiliation_strings":["the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067341789"],"corresponding_institution_ids":["https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":3.7433,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92147588,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"104","issue":"2","first_page":"265","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.3677000105381012,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.3677000105381012,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.16249999403953552,"subfield":{"id":"https://openalex.org/subfields/3604","display_name":"Emergency Medical Services"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycopyrrolate","display_name":"glycopyrrolate","score":1.0},{"id":"https://openalex.org/keywords/upper-respiratory-tract-infection","display_name":"upper respiratory tract infection","score":0.9440000057220459},{"id":"https://openalex.org/keywords/perioperative-complications","display_name":"perioperative complications","score":0.8429999947547913},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.574999988079071},{"id":"https://openalex.org/keywords/anticholinergic-drugs","display_name":"anticholinergic agents","score":0.7900000214576721},{"id":"https://openalex.org/keywords/postoperative-nausea-and-vomiting","display_name":"postoperative nausea and vomiting","score":0.828000009059906},{"id":"https://openalex.org/keywords/respiratory-secretions","display_name":"respiratory secretions","score":0.7160000205039978},{"id":"https://openalex.org/keywords/elective-surgery","display_name":"elective surgery","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2909581452","wikidata":"https://www.wikidata.org/wiki/Q27162963","display_name":"Glycopyrrolate","level":3,"score":0.9462753534317017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9216964840888977},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.8383967876434326},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7184865474700928},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7172030210494995},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7099704742431641},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5936256051063538},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.5700317025184631},{"id":"https://openalex.org/C2780805593","wikidata":"https://www.wikidata.org/wiki/Q2622199","display_name":"Upper respiratory tract infection","level":2,"score":0.548682689666748},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5087993741035461},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.4885879456996918},{"id":"https://openalex.org/C2781312054","wikidata":"https://www.wikidata.org/wiki/Q5354947","display_name":"Elective surgery","level":2,"score":0.4579131007194519},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34990036487579346},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.337044358253479},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24920523166656494},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.1686738133430481},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006024","descriptor_name":"Glycopyrrolate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007431","descriptor_name":"Intraoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007431","descriptor_name":"Intraoperative Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1213/01.ane.0000243333.96141.40","doi":"https://doi.org/10.1213/01.ane.0000243333.96141.40","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000243333.96141.40","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:17242078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17242078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1540888623","https://openalex.org/W1600530570","https://openalex.org/W1932697946","https://openalex.org/W1977033467","https://openalex.org/W1979698912","https://openalex.org/W1980344021","https://openalex.org/W2028180776","https://openalex.org/W2036563432","https://openalex.org/W2048892039","https://openalex.org/W2056757577","https://openalex.org/W2083051392","https://openalex.org/W2093106308","https://openalex.org/W2094360741","https://openalex.org/W2097991032","https://openalex.org/W2107881908","https://openalex.org/W2109223670","https://openalex.org/W2119061500","https://openalex.org/W2120355918","https://openalex.org/W2123651955","https://openalex.org/W2130751892","https://openalex.org/W2414216295","https://openalex.org/W2460264322","https://openalex.org/W2910604630"],"related_works":["https://openalex.org/W4379878495","https://openalex.org/W4381144496","https://openalex.org/W1540888623","https://openalex.org/W2071266807","https://openalex.org/W3025235383","https://openalex.org/W4367555421","https://openalex.org/W7118556719","https://openalex.org/W2411972321","https://openalex.org/W1979698912","https://openalex.org/W2326847515"],"abstract_inverted_index":{"Two":[0],"recent":[1],"studies":[2],"have":[3],"identified":[4],"copious":[5],"secretions":[6,169],"as":[7],"an":[8,27],"independent":[9],"risk":[10],"factor":[11],"for":[12,20,74,93,245],"perioperative":[13,58,100,136,234],"adverse":[14,57,102,138,236],"events":[15,139],"in":[16,23,130,158,184,248],"children":[17,49,64,165,183,225],"who":[18,72],"present":[19],"elective":[21,75],"surgery":[22,76],"the":[24,41,44,54,94,122,131,141,161,180,185,231],"presence":[25],"of":[26,43,56,70,98,135,222,233],"upper":[28],"respiratory":[29,59,101,137,235],"tract":[30],"infection":[31],"(URI).":[32],"We":[33],"designed":[34],"this":[35,249],"study,":[36],"therefore,":[37],"to":[38,48,67,82,111,224],"determine":[39],"whether":[40],"administration":[42],"anticholinergic":[45],"drug,":[46],"glycopyrrolate,":[47,218],"with":[50,77,109,166,179,226],"URIs":[51],"would":[52],"reduce":[53,230],"incidence":[55,132,232],"events.":[60,103],"One":[61],"hundred":[62],"thirty":[63],"(1":[65],"mo":[66],"18":[68],"yr":[69],"age)":[71],"presented":[73],"a":[78],"URI":[79,114],"were":[80,91,107,126,155,170],"randomized":[81],"receive":[83],"either":[84],"0.01":[85],"mg/kg":[86],"glycopyrrolate":[87,142,186],"or":[88,133],"placebo":[89,144,181],"and":[90,96,118,143,168,201,206,238],"followed":[92],"appearance":[95],"severity":[97,134],"any":[99],"The":[104],"two":[105,162],"groups":[106,145,163],"similar":[108],"respect":[110],"demographics,":[112],"presenting":[113],"symptoms,":[115],"anesthetic":[116],"management,":[117],"surgical":[119],"procedure.":[120],"In":[121],"intention-to-treat":[123],"analysis,":[124],"there":[125,154],"no":[127,156],"statistical":[128],"differences":[129,157],"between":[140,160],"(45.2%":[146],"vs":[147,174,195,209],"37.5%":[148],"respectively,":[149],"P":[150,198,211],"=":[151,199,212],"NS).":[152],"Furthermore,":[153],"outcome":[159],"when":[164],"congestion":[167],"analyzed":[171],"separately":[172],"(45.0%":[173],"37.0%,":[175],"respectively).":[176],"However,":[177],"compared":[178],"group,":[182],"group":[187],"had":[188],"significantly":[189,202],"shorter":[190],"discharge":[191],"times":[192],"(83.9":[193],"min":[194],"111.4":[196],"min,":[197],"0.024),":[200],"less":[203],"postoperative":[204],"nausea":[205],"vomiting":[207],"(10.7%":[208],"33.3%,":[210],"0.005).":[213],"These":[214],"results":[215],"suggest":[216],"that":[217],"administered":[219],"after":[220],"induction":[221],"anesthesia":[223],"URIs,":[227],"does":[228],"not":[229,241],"events,":[237],"thus":[239],"may":[240],"be":[242],"clinically":[243],"indicated":[244],"routine":[246],"use":[247],"population.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
