{"id":"https://openalex.org/W2082190878","doi":"https://doi.org/10.1007/s00125-003-1224-3","title":"Globular adiponectin upregulates nitric oxide production in vascular endothelial cells","display_name":"Globular adiponectin upregulates nitric oxide production in vascular endothelial cells","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2082190878","doi":"https://doi.org/10.1007/s00125-003-1224-3","mag":"2082190878","pmid":"https://pubmed.ncbi.nlm.nih.gov/14551684"},"language":"en","primary_location":{"id":"doi:10.1007/s00125-003-1224-3","doi":"https://doi.org/10.1007/s00125-003-1224-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-003-1224-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-003-1224-3.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s00125-003-1224-3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038246750","display_name":"Yoshiyuki Hattori","orcid":"https://orcid.org/0000-0002-4731-0407","observed_orcids":["https://orcid.org/0000-0002-4731-0407"]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Y. Hattori","raw_affiliation_strings":["Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. yhattori@dokkyomed.ac.jp","Dokkyo Univ. School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. yhattori@dokkyomed.ac.jp","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]},{"raw_affiliation_string":"Dokkyo Univ. School of Medicine","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031807429","display_name":"Miho Suzuki","orcid":"https://orcid.org/0000-0003-3147-7672","observed_orcids":["https://orcid.org/0000-0003-3147-7672"]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Suzuki","raw_affiliation_strings":["Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","Dokkyo Univ. School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]},{"raw_affiliation_string":"Dokkyo Univ. School of Medicine","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058216244","display_name":"Sachiko Hattori","orcid":"https://orcid.org/0000-0002-4580-4382","observed_orcids":["https://orcid.org/0000-0002-4580-4382"]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Hattori","raw_affiliation_strings":["Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","Dokkyo Univ. School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]},{"raw_affiliation_string":"Dokkyo Univ. School of Medicine","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045166593","display_name":"Kikuo Kasai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Kasai","raw_affiliation_strings":["Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","Dokkyo Univ. School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]},{"raw_affiliation_string":"Dokkyo Univ. School of Medicine","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038246750"],"corresponding_institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":null,"fwci":4.7729,"has_fulltext":true,"cited_by_count":210,"citation_normalized_percentile":{"value":0.9565601,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"46","issue":"11","first_page":"1543","last_page":"1549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/globular-adiponectin","display_name":"globular adiponectin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6470000147819519},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/enos-phosphorylation","display_name":"eNOS phosphorylation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nitrate-nitrite","display_name":"nitrite/nitrate","score":0.6700000166893005},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.7940000295639038},{"id":"https://openalex.org/keywords/vascular-protection","display_name":"vascular protection","score":0.828000009059906},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.4690000116825104},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.9218879342079163},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.7991049289703369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6718499660491943},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6394903063774109},{"id":"https://openalex.org/C2780189551","wikidata":"https://www.wikidata.org/wiki/Q4065146","display_name":"Vasoprotective","level":3,"score":0.5443567037582397},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5118643641471863},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.43431204557418823},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4160642921924591},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.4141996502876282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3802590072154999},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3773242235183716},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3645389676094055},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.3475399315357208},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2739371061325073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2147078514099121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21088388562202454},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00125-003-1224-3","doi":"https://doi.org/10.1007/s00125-003-1224-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-003-1224-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-003-1224-3.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},{"id":"pmid:14551684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14551684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00125-003-1224-3","doi":"https://doi.org/10.1007/s00125-003-1224-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-003-1224-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-003-1224-3.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317346","display_name":"Japan Private School Promotion Foundation","ror":"https://ror.org/02h1jtt91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082190878.pdf","grobid_xml":"https://content.openalex.org/works/W2082190878.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1524321743","https://openalex.org/W1562891630","https://openalex.org/W1820085648","https://openalex.org/W1928175618","https://openalex.org/W1981261500","https://openalex.org/W1997978122","https://openalex.org/W2010188590","https://openalex.org/W2021838776","https://openalex.org/W2042706232","https://openalex.org/W2046019914","https://openalex.org/W2051031104","https://openalex.org/W2068820862","https://openalex.org/W2069497802","https://openalex.org/W2087018994","https://openalex.org/W2096478205","https://openalex.org/W2097794068","https://openalex.org/W2107865201","https://openalex.org/W2112656429","https://openalex.org/W2113395866","https://openalex.org/W2122484262","https://openalex.org/W2127934772","https://openalex.org/W2138750223","https://openalex.org/W2139801418","https://openalex.org/W2143808884","https://openalex.org/W2156260257","https://openalex.org/W2156678009","https://openalex.org/W2293059847","https://openalex.org/W4321162519"],"related_works":["https://openalex.org/W2021308161","https://openalex.org/W2055378578","https://openalex.org/W2010413021","https://openalex.org/W2025903914","https://openalex.org/W2047320241","https://openalex.org/W3099869057","https://openalex.org/W2075024723","https://openalex.org/W3107239517","https://openalex.org/W2146266563","https://openalex.org/W2351807340"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}